{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T17:57:50Z","timestamp":1767981470472,"version":"3.49.0"},"reference-count":14,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,7,13]]},"abstract":"<jats:title>ABSTRACT.<\/jats:title>\n<jats:p>It is currently not clear whether humoral immunity to Zika virus (ZIKV) elicited upon natural ZIKV infection is long-lasting. In addition, cross-reactivity of anti-ZIKV antibodies with antigenically related dengue viruses (DENV) may have biological implications in nonnaive individuals who subsequently acquire a heterotypic infection. Cross-reactive humoral immunity between ZIKV and DENV also complicates the interpretation of serological tests to evaluate previous exposure to either virus. Here, we have measured the 2-year decay of ZIKV neutralizing antibodies in people living in a ZIKV\/DENV endemic area in Brazil who were identified as having an acute infection (group 1) or past (but recent) infection (group 2) with ZIKV in 2015\u201316. The titers of neutralizing antibodies to ZIKV decreased 9.1 and 2.3 times in groups 1 and 2, respectively. We also show that the plaque reduction neutralization assay (PRNT) is a reliable method to measure past exposure to ZIKV in coendemic areas.<\/jats:p>","DOI":"10.4269\/ajtmh.21-1279","type":"journal-article","created":{"date-parts":[[2022,6,6]],"date-time":"2022-06-06T13:21:19Z","timestamp":1654521679000},"page":"186-189","source":"Crossref","is-referenced-by-count":10,"title":["Two-year Decay of Zika Virus Neutralizing Antibodies in People Living in an Endemic Region in Brazil"],"prefix":"10.4269","volume":"107","author":[{"given":"Tereza","family":"Magalhaes","sequence":"first","affiliation":[{"name":"Department of Preventive and Social Medicine, School of Medicine, Universidade Federal da Bahia, Salvador, Brazil;"},{"name":"Center for Vector-borne Infectious Diseases, Department of Microbiology, Immunology & Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clarice N. L.","family":"Morais","sequence":"additional","affiliation":[{"name":"Department of Virology, Instituto Aggeu Magalh\u00e3es, Funda\u00e7\u00e3o Oswaldo Cruz, Recife, Brazil;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisa A. N.","family":"Azevedo","sequence":"additional","affiliation":[{"name":"Department of Virology, Instituto Aggeu Magalh\u00e3es, Funda\u00e7\u00e3o Oswaldo Cruz, Recife, Brazil;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iracema J. A. A.","family":"Jacques","sequence":"additional","affiliation":[{"name":"Department of Virology, Instituto Aggeu Magalh\u00e3es, Funda\u00e7\u00e3o Oswaldo Cruz, Recife, Brazil;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Priscila M. S.","family":"Castanha","sequence":"additional","affiliation":[{"name":"Infectious Disease and Microbiology Department, University of Pittsburgh, Pittsburgh, Pennsylvania;"},{"name":"Faculty of Medical Science, Universidade de Pernambuco, Recife, Brazil;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marli T.","family":"Cordeiro","sequence":"additional","affiliation":[{"name":"Department of Virology, Instituto Aggeu Magalh\u00e3es, Funda\u00e7\u00e3o Oswaldo Cruz, Recife, Brazil;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cynthia","family":"Braga","sequence":"additional","affiliation":[{"name":"Department of Parasitology, Instituto Aggeu Magalh\u00e3es, Funda\u00e7\u00e3o Oswaldo Cruz, Recife, Brazil;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Jaenisch","sequence":"additional","affiliation":[{"name":"Center for Global Health, Colorado School of Public Health, Aurora, Colorado;"},{"name":"Department of Epidemiology, Colorado School of Public Health, Aurora, Colorado"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ernesto T. A.","family":"Marques","sequence":"additional","affiliation":[{"name":"Infectious Disease and Microbiology Department, University of Pittsburgh, Pittsburgh, Pennsylvania;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian D.","family":"Foy","sequence":"additional","affiliation":[{"name":"Center for Vector-borne Infectious Diseases, Department of Microbiology, Immunology & Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2795","reference":[{"key":"b1","series-title":"PLoS Pathog","doi-asserted-by":"publisher","first-page":"e1007640","DOI":"10.1371\/journal.ppat.1007640","article-title":"The possible role of cross-reactive dengue virus antibodies in Zika virus pathogenesis","volume":"15","year":"2019"},{"key":"b2","series-title":"Emerg Infect Dis","doi-asserted-by":"publisher","first-page":"669","DOI":"10.3201\/eid2304.161549","article-title":"Zika virus seroprevalence, French Polynesia, 2014\u20132015","volume":"23","year":"2017"},{"key":"b3","series-title":"eLife","doi-asserted-by":"publisher","first-page":"e48460","DOI":"10.7554\/eLife.48460","article-title":"Zika seroprevalence declines and neutralizing antibodies wane in adults following outbreaks in French Polynesia and Fiji","volume":"9","year":"2020"},{"key":"b4","series-title":"Viruses","doi-asserted-by":"publisher","first-page":"1345","DOI":"10.3390\/v13071345","article-title":"Zika virus antibody titers three years after confirmed infection","volume":"13","year":"2021"},{"key":"b5","series-title":"Virus Genes","doi-asserted-by":"publisher","first-page":"632","DOI":"10.1007\/s11262-020-01772-2","article-title":"Rapid decline of Zika virus NS1 antigen-specific antibody responses, northeastern Brazil","volume":"56","year":"2020"},{"key":"b6","series-title":"PLoS Negl Trop Dis","doi-asserted-by":"publisher","first-page":"e0006055","DOI":"10.1371\/journal.pntd.0006055","article-title":"Zika virus displacement by a chikungunya outbreak in Recife, Brazil","volume":"11","year":"2017"},{"key":"b7","series-title":"Rev Soc Bras Med Trop","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1590\/0037-8682-0245-2016","article-title":"Zika in Pernambuco: rewriting the first outbreak","volume":"49","year":"2016"},{"key":"b8","series-title":"J Infect Dis","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1093\/infdis\/jiaa563","article-title":"Follow-up household serosurvey in northeast Brazil for Zika virus: sexual contacts of index patients have the highest risk for seropositivity","volume":"223","year":"2021"},{"key":"b9","year":"2017"},{"key":"b10","year":"2019"},{"key":"b11","series-title":"J Infect Dis","doi-asserted-by":"publisher","first-page":"536","DOI":"10.1093\/infdis\/jiy164","article-title":"Longitudinal analysis of antibody cross-neutralization following Zika virus and eengue virus infection in Asia and the Americas","volume":"218","year":"2018"},{"key":"b12","series-title":"Epidemiol Infect","doi-asserted-by":"publisher","first-page":"1080","DOI":"10.1017\/S0950268812001367","article-title":"Force of infection of dengue serotypes in a population-based study in the northeast of Brazil","volume":"141","year":"2013"},{"key":"b13","series-title":"Viruses","doi-asserted-by":"publisher","first-page":"933","DOI":"10.3390\/v12090933","article-title":"Sexual transmission of arboviruses: a systematic review","volume":"12","year":"2020"},{"key":"b14","series-title":"Emerg Infect Dis","doi-asserted-by":"publisher","first-page":"880","DOI":"10.3201\/eid1705.101939","article-title":"Probable non-vector-borne transmission of Zika virus, Colorado, USA","volume":"17","year":"2011"}],"container-title":["The American Journal of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/107\/1\/article-p186.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/107\/1\/article-p186.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/107\/1\/article-p186.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,14]],"date-time":"2022-07-14T09:33:10Z","timestamp":1657791190000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/107\/1\/article-p186.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,13]]},"references-count":14,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.21-1279","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"value":"0002-9637","type":"print"},{"value":"1476-1645","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,13]]}}}