{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T15:20:17Z","timestamp":1792596017487,"version":"4.5.0"},"reference-count":20,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"6","license":[{"start":{"date-parts":[[2022,12,14]],"date-time":"2022-12-14T00:00:00Z","timestamp":1670976000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,12,14]]},"abstract":"<jats:title>ABSTRACT.<\/jats:title>\n<jats:p>Over the past decade, the Pacific region has experienced many arboviral outbreaks, including dengue, chikungunya, and Zika viruses. Papua New Guinea (PNG) has a high burden of arboviral diseases, but there is a paucity of knowledge about the epidemiology and circulation of these viruses in the country. In this study, we report investigations into suspected arboviral outbreaks of febrile disease in PNG from December 2015 to June 2017. DENV-1 and DENV-2 were the mostly commonly detected viruses, and low circulation of DENV-3 and ZIKV was also detected. DENV-4 and CHIKV were not detected during this period. Full genome sequencing of selected positive samples revealed that circulation was dominated by endemic indigenous strains belonging to DENV-1 (genotype IV) and DENV-2 (genotype C) that have been present in the country for up to a decade. A DENV-2 sublineage was also identified that has been associated with outbreaks of severe dengue in both PNG and the Solomon Islands.<\/jats:p>","DOI":"10.4269\/ajtmh.21-1292","type":"journal-article","created":{"date-parts":[[2022,7,5]],"date-time":"2022-07-05T13:13:14Z","timestamp":1657026794000},"page":"1234-1238","source":"Crossref","is-referenced-by-count":10,"title":["Genomic Sequencing of Dengue Virus Strains Associated with Papua New Guinean Outbreaks in 2016 Reveals Endemic Circulation of DENV-1 and DENV-2"],"prefix":"10.4269","volume":"107","author":[{"given":"Marinjho","family":"Jonduo","sequence":"first","affiliation":[{"name":"Papua New Guinea Institute of Medical Research, Goroka, Eastern Highlands Province, Papua New Guinea;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew J.","family":"Neave","sequence":"additional","affiliation":[{"name":"CSIRO Australian Centre for Disease Preparedness, Geelong, Victoria, 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Guinea;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melinda","family":"Susapu","sequence":"additional","affiliation":[{"name":"Papua New Guinea National Department of Health, Port Moresby, Papua New Guinea;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Pomat","sequence":"additional","affiliation":[{"name":"Papua New Guinea Institute of Medical Research, Goroka, Eastern Highlands Province, Papua New Guinea;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Yazid","family":"Abdad","sequence":"additional","affiliation":[{"name":"Papua New Guinea Institute of Medical Research, Goroka, Eastern Highlands Province, Papua New Guinea;"},{"name":"Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, United Kingdom;"},{"name":"Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Thailand;"},{"name":"James Cook University, College of Public Health, Medical and Veterinary Sciences, Townsville, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David T.","family":"Williams","sequence":"additional","affiliation":[{"name":"CSIRO Australian Centre for Disease Preparedness, Geelong, Victoria, Australia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul F.","family":"Horwood","sequence":"additional","affiliation":[{"name":"Papua New Guinea Institute of Medical Research, Goroka, Eastern Highlands Province, Papua New Guinea;"},{"name":"James Cook University, College of Public Health, Medical and Veterinary Sciences, Townsville, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"b1","series-title":"EClinicalMedicine","doi-asserted-by":"publisher","first-page":"100712","DOI":"10.1016\/j.eclinm.2020.100712","article-title":"Global, regional, and national dengue burden from 1990 to 2017: a 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