{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T05:32:53Z","timestamp":1787031173096,"version":"build-2736575974"},"reference-count":38,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"4_Suppl","license":[{"start":{"date-parts":[[2022,10,11]],"date-time":"2022-10-11T00:00:00Z","timestamp":1665446400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,10,11]]},"abstract":"<jats:title>ABSTRACT.<\/jats:title>\n                  <jats:p>\n                    This article highlights over a decade of signature achievements by the West Africa International Centers for Excellence in Malaria Research (WA-ICEMR) and its partners toward guiding malaria prevention and control strategies. Since 2010, the WA-ICEMR has performed longitudinal studies to monitor and assess malaria control interventions with respect to space-time patterns, vector transmission indicators, and drug resistance markers. These activities were facilitated and supported by the Mali National Malaria Control Program. Research activities included large-scale active and passive surveillance and expanded coverage of universal long-lasting insecticide-treated bed nets and seasonal malaria chemoprevention (SMC). The findings revealed substantial declines in malaria occurrence after the scale-up of control interventions in WA-ICEMR study sites. WA-ICEMR studies showed that SMC using sulfadoxine\u2010pyrimethamine plus amodiaquine was highly effective in preventing malaria among children under 5 years of age. An alternative SMC regimen (dihydroartemisinin plus piperaquine) was shown to be potentially more effective and provided advantages for acceptability and compliance over the standard SMC regimen. Other findings discussed in this article include higher observed multiplicity of infection rates for malaria in historically high-endemic areas, continued antimalarial drug sensitivity to\n                    <jats:italic>Plasmodium falciparum<\/jats:italic>\n                    , high outdoor malaria transmission rates, and increased insecticide resistance over the past decade. The progress achieved by the WA-ICEMR and its partners highlights the critical need for maintaining current malaria control interventions while developing novel strategies to disrupt malaria transmission. Enhanced evaluation of these strategies through research partnerships is particularly needed in the wake of reported artemisinin resistance in Southeast Asia and East Africa.\n                  <\/jats:p>","DOI":"10.4269\/ajtmh.21-1309","type":"journal-article","created":{"date-parts":[[2022,10,13]],"date-time":"2022-10-13T17:08:20Z","timestamp":1665680900000},"page":"75-83","source":"Crossref","is-referenced-by-count":12,"title":["A Decade of Progress Accelerating Malaria Control in Mali: Evidence from the West Africa International Center of Excellence for Malaria Research"],"prefix":"10.4269","volume":"107","author":[{"given":"Seydou","family":"Doumbia","sequence":"first","affiliation":[{"name":"Malaria Research and Training Center, University of Sciences, Techniques and Technologies of Bamako, Bamako, Mali;"},{"name":"University Clinical Research Center, University of Sciences, Techniques and Technologies of Bamako, Bamako, Mali;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nafomon","family":"Sogoba","sequence":"additional","affiliation":[{"name":"Malaria Research and Training Center, University of Sciences, Techniques and Technologies of Bamako, Bamako, Mali;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahamadou","family":"Diakite","sequence":"additional","affiliation":[{"name":"Malaria Research and Training Center, University of Sciences, Techniques and Technologies of Bamako, Bamako, Mali;"},{"name":"University Clinical Research Center, University of Sciences, Techniques and Technologies of Bamako, Bamako, Mali;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahamoudou","family":"Toure","sequence":"additional","affiliation":[{"name":"Malaria Research and Training Center, University of Sciences, Techniques and Technologies of Bamako, Bamako, Mali;"},{"name":"University Clinical Research Center, University of Sciences, Techniques and Technologies of Bamako, Bamako, Mali;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moussa","family":"Keita","sequence":"additional","affiliation":[{"name":"Malaria Research and Training Center, University of Sciences, Techniques and Technologies of Bamako, Bamako, Mali;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Drissa","family":"Konat\u00e9","sequence":"additional","affiliation":[{"name":"Malaria Research and Training Center, University of Sciences, Techniques and Technologies of Bamako, Bamako, Mali;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sory I.","family":"Diawara","sequence":"additional","affiliation":[{"name":"Malaria Research and Training Center, University of Sciences, Techniques and Technologies of Bamako, Bamako, Mali;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayouba","family":"Diarra","sequence":"additional","affiliation":[{"name":"Malaria Research and Training Center, University of Sciences, Techniques and Technologies of Bamako, Bamako, Mali;"},{"name":"University Clinical Research Center, University of Sciences, Techniques and Technologies of Bamako, Bamako, Mali;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daouda","family":"Sanogo","sequence":"additional","affiliation":[{"name":"Malaria Research and Training Center, University of Sciences, Techniques and Technologies of Bamako, Bamako, Mali;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fousseyni","family":"Kane","sequence":"additional","affiliation":[{"name":"Malaria Research and Training Center, University of Sciences, Techniques and Technologies of Bamako, Bamako, Mali;"},{"name":"University Clinical Research Center, University of Sciences, Techniques and Technologies of Bamako, Bamako, Mali;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seidina A. S.","family":"Diakite","sequence":"additional","affiliation":[{"name":"Malaria Research and Training Center, University of Sciences, Techniques and Technologies of Bamako, Bamako, Mali;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karim","family":"Traore","sequence":"additional","affiliation":[{"name":"Malaria Research and Training Center, University of Sciences, Techniques and Technologies of Bamako, Bamako, Mali;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sidib\u00e9 M\u2019Baye","family":"Thiam","sequence":"additional","affiliation":[{"name":"Malaria Research and Training Center, University of Sciences, Techniques and Technologies of Bamako, Bamako, Mali;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9kou F.","family":"Traor\u00e9","sequence":"additional","affiliation":[{"name":"Malaria Research and Training Center, University of Sciences, Techniques and Technologies of Bamako, Bamako, Mali;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Idrissa","family":"Cisse","sequence":"additional","affiliation":[{"name":"National Malaria Control Program, Ministry of Health, Bamako, Mali;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jules","family":"Mihigo","sequence":"additional","affiliation":[{"name":"U.S. President\u2019s Malaria Initiative, United States Agency for International Development Office, Bamako, Mali;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mamadou B.","family":"Coulibaly","sequence":"additional","affiliation":[{"name":"Malaria Research and Training Center, University of Sciences, Techniques and Technologies of Bamako, Bamako, Mali;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Djeneba","family":"Dabitao","sequence":"additional","affiliation":[{"name":"University Clinical Research Center, University of Sciences, Techniques and Technologies of Bamako, Bamako, Mali;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Alifrangis","sequence":"additional","affiliation":[{"name":"Centre for Medical Parasitology, Department of Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark; Department of Infectious Diseases, Copenhagen University Hospital (Rigshospitalet), Copenhagen, Denmark;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alyssa E.","family":"Barry","sequence":"additional","affiliation":[{"name":"School of Medicine, Deakin University, Geelong, Australia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00fcnter C.","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Malaria Research and Training Center, University of Sciences, Techniques and Technologies of Bamako, Bamako, Mali;"},{"name":"University Clinical Research Center, University of Sciences, Techniques and Technologies of Bamako, Bamako, Mali;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John C.","family":"Beier","sequence":"additional","affiliation":[{"name":"Miller School of Medicine, University of Miami, Miami, Florida;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey G.","family":"Shaffer","sequence":"additional","affiliation":[{"name":"School of Public Health and Tropical Medicine, Tulane University, New Orleans, Louisiana"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"b1","series-title":"Lancet Infect Dis","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1016\/S1473-3099(14)70712-1","article-title":"The rise and fall of malaria in a West African rural community, Dielmo, Senegal, from 1990 to 2012: a 22 year longitudinal study","volume":"14","year":"2014"},{"key":"b2","series-title":"Nature","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1038\/nature15535","article-title":"The effect of malaria control on Plasmodium falciparum in Africa between 2000 and 2015","volume":"526","year":"2015"},{"key":"b3","series-title":"World Malaria Report 2020","year":"2020"},{"key":"b4","series-title":"Malar J","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1186\/s12936-015-0829-6","article-title":"On-going malaria transmission in The Gambia despite high coverage of control interventions: a nationwide cross-sectional survey","volume":"14","year":"2015"},{"key":"b5","series-title":"Malar J","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1186\/1475-2875-13-374","article-title":"Stable malaria incidence despite scaling up control strategies in a malaria vaccine-testing site in Mali","volume":"13","year":"2014"},{"key":"b6","year":"2014"},{"key":"b7","series-title":"Malar J","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1186\/1475-2875-11-435","article-title":"Increasing incidence of malaria in children despite insecticide-treated bed nets and prompt anti-malarial therapy in Tororo, Uganda","volume":"11","year":"2012"},{"key":"b8","series-title":"Am J Trop Med Hyg","doi-asserted-by":"publisher","first-page":"1","DOI":"10.4269\/ajtmh.15-0407","article-title":"Foreword: international centers of excellence for malaria research","volume":"93","year":"2015"},{"key":"b9","series-title":"Acta Trop","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1016\/j.actatropica.2011.11.005","article-title":"Sahel, savana, riverine and urban malaria in West Africa: similar control policies with different outcomes","volume":"121","year":"2012"},{"key":"b10","series-title":"Acta Trop","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/j.actatropica.2011.11.009","article-title":"Improving malaria control in West Africa: interruption of transmission as a paradigm shift","volume":"121","year":"2012"},{"key":"b11","year":"2016"},{"key":"b12"},{"key":"b13","series-title":"Lancet Glob Health","doi-asserted-by":"publisher","first-page":"e500","DOI":"10.1016\/S2214-109X(18)30065-2","article-title":"The Millennium Villages Project: a retrospective, observational, endline evaluation","volume":"6","year":"2018"},{"key":"b14","year":"2009"},{"key":"b15","doi-asserted-by":"publisher","year":"2011","DOI":"10.1016\/S2214-109X(18)30199-2"},{"key":"b16","series-title":"Lancet Glob Health","first-page":"e472","article-title":"Lessons from the Millennium Villages Project: a personal perspective","volume":"6","year":"2018"},{"key":"b17","doi-asserted-by":"publisher","DOI":"10.1186\/s40249-018-0494-4"},{"key":"b18","series-title":"Infect Dis Poverty","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1186\/s12936-019-3063-9","article-title":"Development of a data collection and management system in West Africa: challenges and sustainability","volume":"7","year":"2018"},{"key":"b19","series-title":"Malar J","doi-asserted-by":"publisher","first-page":"33","DOI":"10.3390\/ijerph17134698","article-title":"Clustering of asymptomatic Plasmodium falciparum infection and the effectiveness of targeted malaria control measures","volume":"19","year":"2020"},{"key":"b20","series-title":"Int J Environ Res Public Health","doi-asserted-by":"publisher","first-page":"4698","DOI":"10.1186\/s12936-020-03357-8","article-title":"Spatio-temporal dynamic of malaria incidence: a comparison of two ecological zones in Mali","volume":"17","year":"2020"},{"key":"b21","series-title":"Malar J","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1186\/s12936-021-03650-0","article-title":"Performance of IRS on malaria prevalence and incidence using pirimiphos-methyl in the context of pyrethroid resistance in Koulikoro region, Mali","volume":"19","year":"2020"},{"key":"b22","series-title":"Malar J","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1186\/s12936-019-2986-5","article-title":"Indoor and outdoor malaria transmission in two ecological settings in rural Mali: implications for vector control","volume":"20","year":"2021"},{"key":"b23","series-title":"Malar J","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1007\/s40268-020-00313-4","article-title":"A comprehensive analysis of drug resistance molecular markers and Plasmodium falciparum genetic diversity in two malaria endemic sites in Mali","volume":"18","year":"2019"},{"key":"b24","series-title":"Drugs R D","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1186\/s12936-022-04058-0","article-title":"Ex-vivo sensitivity of Plasmodium falciparum to common anti-malarial drugs: the case of Kenieroba, a malaria endemic village in Mali","volume":"20","year":"2020"},{"key":"b25","series-title":"Malar J","doi-asserted-by":"publisher","first-page":"65","DOI":"10.3390\/ijerph17176339","article-title":"Trends in malaria epidemiological factors following the implementation of current control strategies in Dangassa, Mali","volume":"21","year":"2022"},{"key":"b26","series-title":"Int J Environ Res Public Health","first-page":"6339","article-title":"Predicting malaria transmission dynamics in Dangassa, Mali: a novel approach using functional generalized additive models","volume":"17","year":"2020"},{"key":"b27","series-title":"Am J Trop Med Hyg","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1186\/1475-2875-9-262","article-title":"Effectiveness and community acceptance of extending seasonal malaria chemoprevention to children 5 to 14 years of age in Dangassa, Mali","volume":"106","year":"2021"},{"key":"b28","series-title":"Malar J","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1016\/j.actatropica.2020.105820","article-title":"Field experiments of Anopheles gambiae attraction to local fruits\/seedpods and flowering plants in Mali to optimize strategies for malaria vector control in Africa using attractive toxic sugar bait methods","volume":"9","year":"2010"},{"key":"b29","series-title":"Acta Trop","doi-asserted-by":"publisher","first-page":"105820","DOI":"10.1093\/infdis\/jiaa190","article-title":"Performance of pirimiphos-methyl based indoor residual spraying on entomological parameters of malaria transmission in the pyrethroid resistance region of Koulikoro, Mali","volume":"216","year":"2021"},{"key":"b30","series-title":"J Infect Dis","doi-asserted-by":"publisher","first-page":"S81","DOI":"10.1186\/s13071-020-04150-x","article-title":"Multiple resistance mechanisms to pyrethroids insecticides in Anopheles gambiae sensu lato population from Mali, West Africa","volume":"223","year":"2021"},{"key":"b31","series-title":"Parasit Vectors","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1186\/s13071-020-04100-7","article-title":"Acetylcholinesterase (ace-1(R)) target site mutation G119S and resistance to carbamates in Anopheles gambiae (sensu lato) populations from Mali","volume":"13","year":"2020"},{"key":"b32","series-title":"Parasit Vectors","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1016\/S1473-3099(16)30378-4","article-title":"Anopheles gambiae (s.l.) exhibit high intensity pyrethroid resistance throughout southern and central Mali (2016\u20132018): PBO or next generation LLINs may provide greater control","volume":"13","year":"2020"},{"key":"b33","series-title":"Lancet Infect Dis","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1038\/s41591-020-1005-2","article-title":"Safety, tolerability, and efficacy of repeated doses of dihydroartemisinin-piperaquine for prevention and treatment of malaria: a systematic review and meta-analysis","volume":"17","year":"2017"},{"key":"b34","series-title":"Nat Med","first-page":"1602","article-title":"Emergence and clonal expansion of in\u00a0vitro artemisinin-resistant Plasmodium falciparum kelch13 R561H mutant parasites in Rwanda","volume":"26","year":"2020"},{"key":"b35","doi-asserted-by":"publisher","year":"2014","DOI":"10.1186\/s12936-021-03704-3"},{"key":"b36","series-title":"Malar J","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1186\/s12936-021-03684-4","article-title":"Testing configurations of attractive toxic sugar bait (ATSB) stations in Mali, West Africa, for improving the control of malaria parasite transmission by vector mosquitoes and minimizing their effect on non-target insects","volume":"20","year":"2021"},{"key":"b37","series-title":"Malar J","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1186\/s12936-021-03761-8","article-title":"Estimating the potential impact of Attractive Targeted Sugar Baits (ATSBs) as a new vector control tool for Plasmodium falciparum malaria","volume":"20","year":"2021"},{"key":"b38","series-title":"Malar J","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1016\/S1473-3099(14)70712-1","article-title":"Reactive, self-administered malaria treatment against asymptomatic malaria infection: results of a cluster randomized controlled trial in The Gambia","volume":"20","year":"2021"}],"container-title":["The American Journal of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/107\/4_Suppl\/article-p75.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/107\/4_Suppl\/article-p75.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/107\/4_Suppl\/article-p75.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,13]],"date-time":"2022-10-13T17:12:21Z","timestamp":1665681141000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/107\/4_Suppl\/article-p75.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,11]]},"references-count":38,"journal-issue":{"issue":"4_Suppl"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.21-1309","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"value":"0002-9637","type":"print"},{"value":"1476-1645","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,11]]}}}