{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T12:20:11Z","timestamp":1789129211436,"version":"build-2803163510"},"reference-count":45,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"3_Suppl","license":[{"start":{"date-parts":[[2022,9,9]],"date-time":"2022-09-09T00:00:00Z","timestamp":1662681600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,9,9]]},"abstract":"<jats:title>ABSTRACT.<\/jats:title>\n<jats:p>Transmission-blocking vaccines (TBVs), pioneered by Richard Carter and others, aim to prevent parasite development in the mosquito vector and are a promising new tool for malaria elimination. Pfs47, recently identified as a TBV target, is a three-domain 6-cysteine protein on the surface of <jats:italic>Plasmodium falciparum<\/jats:italic> sexual stages. Pfs47 allows the parasite to evade mosquito immunity and is key for <jats:italic>P. falciparum<\/jats:italic> infection of the dominant malaria vectors <jats:italic>Anopheles gambiae<\/jats:italic>, <jats:italic>Anopheles dirus<\/jats:italic>, and <jats:italic>Anopheles albimanus<\/jats:italic>. Antibodies against Pfs47 domain 2 (D2) have significant transmission-blocking activity that prevents <jats:italic>Plasmodium<\/jats:italic> ookinete development and is independent of human complement. Strong transmission-blocking activity has been mapped to a region of 52 amino acids in Pfs47 D2. Efforts to optimize the immunogenicity of the Pfs47 D2 antigen with a viral-like particle have been successful, and the efficacy of a P47-based TBV was confirmed in\u00a0vivo with Pbs47, the orthologue of Pfs47 in the mouse malaria parasite <jats:italic>Plasmodium berghei<\/jats:italic>. The current evidence warrants further development and clinical testing of a Pfs47-based TBV.<\/jats:p>","DOI":"10.4269\/ajtmh.21-1325","type":"journal-article","created":{"date-parts":[[2022,7,11]],"date-time":"2022-07-11T12:36:37Z","timestamp":1657542997000},"page":"27-31","source":"Crossref","is-referenced-by-count":22,"title":["Pfs47 as a Malaria Transmission-Blocking Vaccine Target"],"prefix":"10.4269","volume":"107","author":[{"given":"Alvaro","family":"Molina-Cruz","sequence":"first","affiliation":[{"name":"Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Barillas-Mury","sequence":"additional","affiliation":[{"name":"Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, 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