{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T05:32:54Z","timestamp":1787031174904,"version":"build-2736575974"},"reference-count":19,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,7,13]]},"abstract":"<jats:title>ABSTRACT.<\/jats:title>\n                  <jats:p>\n                    The diagnosis of neurocysticercosis (NCC) is principally based on neuroimaging (magnetic resonance imaging or computed tomography), instrumentation that is scarcely available in the rural regions where\n                    <jats:italic>Taenia solium<\/jats:italic>\n                    transmission, primarily occurs due to poor sanitation conditions. Immunological assays for antigen or antibody detection complement the neuroimaging approach. However, no field-applicable assays to diagnose viable NCC or to guide the referral of cases for neuroimaging or for appropriate management are available. We performed an exploratory study on urine and serum samples using\n                    <jats:sup>1<\/jats:sup>\n                    H-nuclear magnetic resonance (NMR)-based metabolomics to discriminate NCC patients (\n                    <jats:italic>n<\/jats:italic>\n                    = 14) from healthy control subjects (\n                    <jats:italic>n<\/jats:italic>\n                    = 22). Metabolic profiles demonstrated a discrimination between the urines of NCC patients and noninfected control subjects with a moderate predictive accuracy (\n                    <jats:italic>R<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    = 0.999,\n                    <jats:italic>Q<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    = 0.434). NMR metabolomics analysis has been proven useful in depicting biomarkers linked to other infectious diseases, various types of cancer, and other disorders. Our results, albeit preliminary, open a door to the development of better methods for detecting NCC through the identification of biomarkers participating in disturbed metabolic pathways.\n                  <\/jats:p>","DOI":"10.4269\/ajtmh.22-0045","type":"journal-article","created":{"date-parts":[[2022,5,23]],"date-time":"2022-05-23T10:56:47Z","timestamp":1653303407000},"page":"143-145","source":"Crossref","is-referenced-by-count":3,"title":["Urine 1H-NMR Metabolomics to Discriminate Neurocysticercosis Patients from Healthy Controls: An Exploratory Study"],"prefix":"10.4269","volume":"107","author":[{"given":"Juan M.","family":"Lopez","sequence":"first","affiliation":[{"name":"Departamento de Ciencias\u2014Qu\u00edmica, CERMN, Pontificia Universidad Cat\u00f3lica del Per\u00fa, Lima, Per\u00fa;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa E.","family":"Leyva","sequence":"additional","affiliation":[{"name":"Departamento de Ciencias\u2014Qu\u00edmica, CERMN, Pontificia Universidad Cat\u00f3lica del Per\u00fa, Lima, Per\u00fa;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier A.","family":"Bustos","sequence":"additional","affiliation":[{"name":"Cysticercosis Unit, Instituto Nacional de Ciencias Neurologicas, Lima, Per\u00fa;"},{"name":"Center for Global Health, Universidad Peruana Cayetano Heredia, Lima, Per\u00fa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika","family":"Perez","sequence":"additional","affiliation":[{"name":"Cysticercosis Unit, Instituto Nacional de Ciencias Neurologicas, Lima, Per\u00fa;"},{"name":"Center for Global Health, Universidad Peruana Cayetano Heredia, Lima, Per\u00fa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sof\u00eda S.","family":"Sanchez","sequence":"additional","affiliation":[{"name":"Center for Global Health, Universidad Peruana Cayetano Heredia, Lima, Per\u00fa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herbert","family":"Saavedra","sequence":"additional","affiliation":[{"name":"Center for Global Health, Universidad Peruana Cayetano Heredia, Lima, Per\u00fa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isidro","family":"Gonzales","sequence":"additional","affiliation":[{"name":"Center for Global Health, Universidad Peruana Cayetano Heredia, Lima, Per\u00fa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena","family":"Maruenda","sequence":"additional","affiliation":[{"name":"Departamento de Ciencias\u2014Qu\u00edmica, CERMN, Pontificia Universidad Cat\u00f3lica del Per\u00fa, Lima, Per\u00fa;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hector H.","family":"Garcia","sequence":"additional","affiliation":[{"name":"Cysticercosis Unit, Instituto Nacional de Ciencias Neurologicas, Lima, Per\u00fa;"},{"name":"Center for Global Health, Universidad Peruana Cayetano Heredia, Lima, Per\u00fa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"_","family":"_","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"b1","series-title":"Clin Microbiol Rev","first-page":"e00085","article-title":"Taenia solium cysticercosis and its impact in neurological disease","volume":"33","year":"2020"},{"key":"b2","series-title":"J Neurol Sci","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1016\/j.jns.2016.11.045","article-title":"Revised diagnostic criteria for neurocysticercosis","volume":"372","year":"2017"},{"key":"b3","series-title":"Trop Med Int Health","doi-asserted-by":"publisher","first-page":"1014","DOI":"10.1111\/j.1365-3156.2012.03037.x","article-title":"Neurocysticercosis: is serology useful in the absence of brain imaging?","volume":"17","year":"2012"},{"key":"b4","series-title":"Am J Trop Med Hyg","doi-asserted-by":"publisher","first-page":"1125","DOI":"10.4269\/ajtmh.20-0196","article-title":"Population screening for urine antigens to detect asymptomatic subarachnoid neurocysticercosis: a pilot study in northern Peru","volume":"103","year":"2020"},{"key":"b5","series-title":"Am J Trop Med Hyg","doi-asserted-by":"publisher","first-page":"379","DOI":"10.4269\/ajtmh.2009.80.379","article-title":"Urine antigen detection for the diagnosis of human neurocysticercosis","volume":"80","year":"2009"},{"key":"b6","series-title":"Am J Trop Med Hyg","doi-asserted-by":"publisher","first-page":"327","DOI":"10.4269\/ajtmh.18-0706","article-title":"Detection of Taenia solium DNA in the urine of neurocysticercosis patients","volume":"100","year":"2019"},{"key":"b7","series-title":"Mol Biochem Parasitol","doi-asserted-by":"publisher","first-page":"111314","DOI":"10.1016\/j.molbiopara.2020.111314","article-title":"Diagnostic urinary cfDNA detected in human cystic echinococcosis","volume":"239","year":"2020"},{"key":"b8","series-title":"Nat Protoc","doi-asserted-by":"publisher","first-page":"2692","DOI":"10.1038\/nprot.2007.376","article-title":"Metabolic profiling, metabolomic and metabonomic procedures for NMR spectroscopy of urine, plasma, serum and tissue extracts","volume":"2","year":"2007"},{"key":"b9","series-title":"Chem Commun (Camb)","first-page":"811","article-title":"Spin echo NMR spectra without J modulation","volume":"48","year":"2011"},{"key":"b10","series-title":"Magnetic Resonance in Food Science","first-page":"14","author":"Savorani","year":"2013"},{"key":"b11","series-title":"Comb Chem High Throughput Screen","doi-asserted-by":"publisher","first-page":"595","DOI":"10.2174\/138620712802650522","article-title":"Application of NMR metabolomics to search for human disease biomarkers","volume":"15","year":"2012"},{"key":"b12","series-title":"J Proteome Res","doi-asserted-by":"publisher","first-page":"2238","DOI":"10.1021\/pr101054m","article-title":"(1)H NMR-based metabolomic profiling in mice infected with Mycobacterium tuberculosis.","volume":"10","year":"2011"},{"key":"b13","series-title":"NMR Biomed","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1002\/nbm.1323","article-title":"Metabolite profiling of the intraerythrocytic malaria parasite Plasmodium falciparum by (1)H NMR spectroscopy","volume":"22","year":"2009"},{"key":"b14","series-title":"Biomarkers Med","doi-asserted-by":"publisher","first-page":"195","DOI":"10.2217\/bmm.10.11","article-title":"NMR-based analysis of metabolites in urine provides rapid diagnosis and etiology of pneumonia","volume":"4","year":"2010"},{"key":"b15","series-title":"Nat Rev Urol","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1038\/nrurol.2011.53","article-title":"A decade in prostate cancer: from NMR to metabolomics","volume":"8","year":"2011"},{"key":"b16","series-title":"Metabolites","doi-asserted-by":"publisher","first-page":"552","DOI":"10.3390\/metabo3030552","article-title":"A review of applications of metabolomics in cancer","volume":"3","year":"2013"},{"key":"b17","series-title":"NMR Biomed","first-page":"e3916","article-title":"Nuclear magnetic resonance (NMR)-based metabolomics for cancer research","volume":"32","year":"2019"},{"key":"b18","series-title":"J Biomed Sci","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1186\/1423-0127-16-63","article-title":"Metabolic profiling of Parkinson\u2019s disease: evidence of biomarker from gene expression analysis and rapid neural network detection","volume":"16","year":"2009"},{"key":"b19","series-title":"NMR Biomed","first-page":"123","article-title":"NMR-based metabolomic analysis of cerebrospinal fluid and serum in neurological diseases\u2014a diagnostic tool?","volume":"23","year":"2010"}],"container-title":["The American Journal of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/107\/1\/article-p143.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/107\/1\/article-p143.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/107\/1\/article-p143.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,13]],"date-time":"2022-07-13T13:39:31Z","timestamp":1657719571000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/107\/1\/article-p143.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,13]]},"references-count":19,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.22-0045","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"value":"0002-9637","type":"print"},{"value":"1476-1645","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,13]]}}}