{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T23:55:01Z","timestamp":1782258901762,"version":"3.54.5"},"reference-count":11,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,6,15]]},"abstract":"<jats:title>ABSTRACT.<\/jats:title>\n<jats:p>Adult-onset subacute sclerosing panencephalitis (SSPE) is rare, and focal myoclonus as a presenting feature poses a diagnostic dilemma. We report an adult SSPE patient with unusual clinical and radiological features. A 20-year-old girl had jerky neck movement 9 months earlier, which progressed to left hemimyoclonus in 2 months and generalized frequent myoclonus and fall at 4 months. By 6 months, she was bedbound. On examination, her Mini-Mental State Examination score was 10, and patchy retinitis was observed around the macula. Magnetic resonance imaging revealed corpus striatal involvement and electroencephalography showed periodic discharges. Measles cerebrospinal fluid\/serum immunoglobulin G index was 3.3 (normal &lt; 1.3), confirming the diagnosis of SSPE. SSPE should also be considered in adults having focal myoclonus with corpus striatal lesion. EEG is helpful in the diagnosis.<\/jats:p>","DOI":"10.4269\/ajtmh.22-0046","type":"journal-article","created":{"date-parts":[[2022,5,9]],"date-time":"2022-05-09T13:03:43Z","timestamp":1652101423000},"page":"1729-1731","source":"Crossref","is-referenced-by-count":3,"title":["Case Report: Focal Myoclonus with a Striatal Lesion as a Presentation of Subacute Sclerosing Panencephalitis"],"prefix":"10.4269","volume":"106","author":[{"given":"Jayantee","family":"Kalita","sequence":"first","affiliation":[{"name":"Department of Neurology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarvesh K.","family":"Chaudhury","sequence":"additional","affiliation":[{"name":"Department of Neurology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bishwanath","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Neurology, Adhikari Neurocentre, Patna, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahesh","family":"Jadhav","sequence":"additional","affiliation":[{"name":"Department of Neurology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"b1","series-title":"Curr Neurol Neurosci Rep","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1007\/s11910-020-1023-y","article-title":"Neurological complications of measles (rubeola)","volume":"20","year":"2020"},{"key":"b2","series-title":"JAMA","doi-asserted-by":"publisher","first-page":"2248","DOI":"10.1001\/jama.1969.03150250078007","article-title":"Subacute sclerosing panencephalitis. a multidisciplinary study of eight cases","volume":"207","year":"1969"},{"key":"b3","series-title":"J Mol Neurosci","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1007\/s12031-020-01654-0","article-title":"Movement disorder in Wilson disease: correlation with MRI and biomarkers of cell injury","volume":"71","year":"2021"},{"key":"b4","series-title":"Rev Neurol (Paris)","first-page":"829","article-title":"Sympt\u00f4mes et signes cliniques, donn\u00e9es du laboratoire dans 80 cas de panenc\u00e9phalite scl\u00e9rosante subaigu\u00eb","volume":"144","year":"1988"},{"key":"b5","series-title":"Clin Neurophysiol","doi-asserted-by":"publisher","first-page":"1947","DOI":"10.1016\/j.clinph.2007.06.008","article-title":"Electroencephalographic and imaging profile in a subacute sclerosing panencephalitis (SSPE) cohort: a correlative study","volume":"118","year":"2007"},{"key":"b6","series-title":"J Magn Reson Imaging","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1002\/jmri.20518","article-title":"Subacute sclerosing panencephalitis: relationship between clinical stage and diffusion-weighted imaging findings","volume":"23","year":"2006"},{"key":"b7","series-title":"Neurology","doi-asserted-by":"publisher","first-page":"938","DOI":"10.1212\/WNL.0000000000000749","article-title":"Neuronal loss is an early component of subacute sclerosing panencephalitis","volume":"83","year":"2014"},{"key":"b8","series-title":"Clin Nucl Med","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1097\/RLU.0b013e3181e9fa5f","article-title":"A correlative study of FDG PET, MRI\/CT, electroencephalography, and clinical features in subacute sclerosing panencephalitis","volume":"35","year":"2010"},{"key":"b9","series-title":"J Child Neurol","first-page":"173","article-title":"Use of a brief assessment exam in a study involving isoprinosine and alpha interferon treatment of SSPE","volume":"11","year":"1996"},{"key":"b10","series-title":"J Child Neurol","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1177\/08830738030180020701","article-title":"Combined treatment with subcutaneous interferon-alpha, oral isoprinosine, and lamivudine for subacute sclerosing panencephalitis","volume":"18","year":"2003"},{"key":"b11","series-title":"J Child Neurol","doi-asserted-by":"publisher","first-page":"819","DOI":"10.1177\/088307380301801201","article-title":"International Consortium on Subacute Sclerosing Panencephalitis. Randomized treatment study of inosiplex versus combined inosiplex and intraventricular interferon-alpha in subacute sclerosing panencephalitis (SSPE): international multicenter study","volume":"18","year":"2003"}],"container-title":["The American Journal of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/106\/6\/article-p1729.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/106\/6\/article-p1729.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/106\/6\/article-p1729.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,19]],"date-time":"2022-07-19T20:17:19Z","timestamp":1658261839000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/106\/6\/article-p1729.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,15]]},"references-count":11,"journal-issue":{"issue":"6"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.22-0046","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"value":"0002-9637","type":"print"},{"value":"1476-1645","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,15]]}}}