{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T12:28:35Z","timestamp":1792758515440,"version":"4.5.0"},"reference-count":21,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,8,17]]},"abstract":"<jats:title>ABSTRACT.<\/jats:title>\n<jats:p>Chikungunya virus (CHIKV) is recognized but rarely considered as a cause of central nervous system infection in endemic areas. A total of 244 patients with acute meningoencephalitis in Indonesia were retrospectively tested to identify whether any CHIKV infection was associated with neurological manifestations, especially in provinces known for CHIKV endemicity. Cerebrospinal fluid (CSF) and blood specimens were tested using CHIKV-specific real-time reverse transcription polymerase chain reaction and IgM ELISA, alongside a panel of neurotropic viruses. We report four cases of suspected or confirmed CHIKV-associated neurological disease, including CHIKV RNA detection in CSF of one patient and in acute serum of another, and CHIKV IgM in CSF of three patients and in serum of a fourth. In conclusion, CHIKV should be considered as a cause of neurologic disease in endemic areas and especially during outbreaks, in addition to the more common arboviral diseases such as dengue and Japanese encephalitis viruses.<\/jats:p>","DOI":"10.4269\/ajtmh.22-0050","type":"journal-article","created":{"date-parts":[[2022,6,13]],"date-time":"2022-06-13T12:19:26Z","timestamp":1655122766000},"page":"291-295","source":"Crossref","is-referenced-by-count":12,"title":["Neurological Disease Associated with Chikungunya in Indonesia"],"prefix":"10.4269","volume":"107","author":[{"given":"Khin S. A.","family":"Myint","sequence":"first","affiliation":[{"name":"Eijkman Institute for Molecular Biology, Jakarta, Indonesia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur H. P.","family":"Mawuntu","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Universitas Sam Ratulangi, R.D. Kandou Hospital, Manado, Indonesia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sotianingsih","family":"Haryanto","sequence":"additional","affiliation":[{"name":"Raden Mattaher Hospital, Jambi, Indonesia;"},{"name":"Faculty of Medicine and Health Sciences, Universitas Jambi, Jambi, Indonesia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darma","family":"Imran","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofiati","family":"Dian","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yora P.","family":"Dewi","sequence":"additional","affiliation":[{"name":"Eijkman Institute for Molecular Biology, Jakarta, Indonesia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad R.","family":"Ganiem","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riane","family":"Anggreani","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Universitas Sam Ratulangi, R.D. Kandou Hospital, Manado, Indonesia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirna M.","family":"Iskandar","sequence":"additional","affiliation":[{"name":"Raden Mattaher Hospital, Jambi, Indonesia;"},{"name":"Faculty of Medicine and Health Sciences, Universitas Jambi, Jambi, Indonesia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janno B. B.","family":"Bernadus","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Universitas Sam Ratulangi, R.D. Kandou Hospital, Manado, Indonesia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kartika","family":"Maharani","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Susanto","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Universitas Sam Ratulangi, R.D. Kandou Hospital, Manado, Indonesia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riwanti","family":"Estiasari","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hasna","family":"Dewi","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health Sciences, Universitas Jambi, Jambi, Indonesia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Kristiani","sequence":"additional","affiliation":[{"name":"KS Prima Laboratory, Jambi, Indonesia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lidia","family":"Gaghiwu","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Universitas Sam Ratulangi, R.D. Kandou Hospital, Manado, Indonesia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edison","family":"Johar","sequence":"additional","affiliation":[{"name":"Eijkman Institute for Molecular Biology, Jakarta, Indonesia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frilasita A.","family":"Yudhaputri","sequence":"additional","affiliation":[{"name":"Eijkman Institute for Molecular Biology, Jakarta, Indonesia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ungke","family":"Antonjaya","sequence":"additional","affiliation":[{"name":"Eijkman Institute for Molecular Biology, Jakarta, Indonesia;"},{"name":"Eijkman-Oxford Clinical Research Unit, Jakarta, Indonesia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy P.","family":"Ledermann","sequence":"additional","affiliation":[{"name":"Centers for Disease Control and Prevention, Fort Collins, Colorado;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reinout","family":"van Crevel","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Radboud University Medical Center, Nijmegen, The Netherlands;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raph L.","family":"Hamers","sequence":"additional","affiliation":[{"name":"Eijkman-Oxford Clinical Research Unit, Jakarta, Indonesia;"},{"name":"Nuffield Department of Medicine, Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann M.","family":"Powers","sequence":"additional","affiliation":[{"name":"Centers for Disease Control and Prevention, Fort Collins, Colorado;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"b1","series-title":"Neurology","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1212\/WNL.0000000000002234","article-title":"Chikungunya virus-associated encephalitis: a cohort study on La R\u00e9union Island, 2005\u20132009","volume":"86","author":"G\u00e9rardin","year":"2016"},{"key":"b2","series-title":"Methods Mol Biol","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1007\/978-1-4939-3618-2_12","article-title":"Analysis of CHIKV in mosquitoes infected via artificial blood meal","volume":"1426","author":"Ledermann","year":"2016"},{"key":"b3","series-title":"PLoS One","doi-asserted-by":"publisher","first-page":"e0207440","DOI":"10.1371\/journal.pone.0207440","article-title":"Detection of central nervous system viral infections in adults in Manado, North Sulawesi, Indonesia","volume":"13","author":"Mawuntu","year":"2018"},{"key":"b4","series-title":"J Clin Microbiol","doi-asserted-by":"publisher","first-page":"1823","DOI":"10.1128\/JCM.38.5.1823-1826.2000","article-title":"Standardization of immunoglobulin M capture enzyme-linked immunosorbent assays for routine diagnosis of arboviral infections","volume":"38","author":"Martin","year":"2000"},{"key":"b5","series-title":"Nat Protoc","doi-asserted-by":"publisher","first-page":"1261","DOI":"10.1038\/nprot.2017.066","article-title":"Multiplex PCR method for MinION and Illumina sequencing of Zika and other virus genomes directly from clinical samples","volume":"12","author":"Quick","year":"2017"},{"key":"b6","series-title":"Rev Med Virol","doi-asserted-by":"publisher","first-page":"e1978","DOI":"10.1002\/rmv.1978","article-title":"The neurological complications of chikungunya virus: a systematic review","volume":"28","author":"Mehta","year":"2018"},{"key":"b7","series-title":"Am J Trop Med Hyg","doi-asserted-by":"publisher","first-page":"727","DOI":"10.4269\/ajtmh.2007.77.727","article-title":"A major epidemic of Chikungunya virus infection on R\u00e9union Island, France, 2005\u20132006","volume":"77","author":"Renault","year":"2007"},{"key":"b8","series-title":"Am J Trop Med Hyg","doi-asserted-by":"publisher","first-page":"386","DOI":"10.4269\/ajtmh.2011.10-0725","article-title":"Case reports of neuro-Chikungunya in southern Thailand","volume":"85","author":"Chusri","year":"2011"},{"key":"b9","series-title":"Neurol India","doi-asserted-by":"publisher","first-page":"177","DOI":"10.4103\/0028-3886.51289","article-title":"Neurological complications of Chikungunya virus infection","volume":"57","author":"Chandak","year":"2009"},{"key":"b10","series-title":"Lancet Neurol","doi-asserted-by":"publisher","first-page":"826","DOI":"10.1016\/S1474-4422(20)30232-5","article-title":"Neurological disease in adults with Zika and Chikungunya virus infection in northeast Brazil: a prospective observational study","volume":"19","author":"Brito Ferreira","year":"2020"},{"key":"b11","series-title":"Emerg Infect Dis","doi-asserted-by":"publisher","first-page":"2066","DOI":"10.3201\/eid1812.120471","article-title":"Reemergence of chikungunya virus in Cambodia","volume":"18","author":"Duong","year":"2012"},{"key":"b12","series-title":"BMC Infect Dis","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1186\/s12879-019-3857-y","article-title":"Chikungunya virus infection in Indonesia: a systematic review and evolutionary analysis","volume":"19","author":"Harapan","year":"2019"},{"key":"b13","series-title":"PLoS Negl Trop Dis","doi-asserted-by":"publisher","first-page":"e2483","DOI":"10.1371\/journal.pntd.0002483","article-title":"Evidence for endemic Chikungunya virus infections in Bandung, Indonesia","volume":"7","author":"Kosasih","year":"2013"},{"key":"b14","series-title":"PLoS Negl Trop Dis","doi-asserted-by":"publisher","first-page":"e0008355","DOI":"10.1371\/journal.pntd.0008355","article-title":"Chikungunya in Indonesia: epidemiology and diagnostic challenges","volume":"14","author":"Arif","year":"2020"},{"key":"b15","series-title":"Am J Trop Med Hyg","doi-asserted-by":"publisher","first-page":"1393","DOI":"10.4269\/ajtmh.16-0935","article-title":"Chikungunya detection during dengue outbreak in Sumatra, Indonesia: clinical manifestations and virological profile","volume":"97","author":"Sasmono","year":"2017"},{"key":"b16","series-title":"PLoS Negl Trop Dis","doi-asserted-by":"publisher","first-page":"e2331","DOI":"10.1371\/journal.pntd.0002331","article-title":"Dengue and other common causes of acute febrile illness in Asia: an active surveillance study in children","volume":"7","author":"Capeding","year":"2013"},{"key":"b17","series-title":"Emerg Infect Dis","doi-asserted-by":"publisher","first-page":"329","DOI":"10.3201\/eid1502.080902","article-title":"Chikungunya virus and central nervous system infections in children, India","volume":"15","author":"Lewthwaite","year":"2009"},{"key":"b18","series-title":"Indian J Crit Care Med","doi-asserted-by":"publisher","first-page":"306","DOI":"10.4103\/ijccm.IJCCM_459_17","article-title":"Atypical neurological manifestations of chikungunya fever: two case reports","volume":"22","author":"Mahto","year":"2018"},{"key":"b19","series-title":"Clin Infect Dis","doi-asserted-by":"publisher","first-page":"942","DOI":"10.1086\/605496","article-title":"Chikungunya fever: an epidemiological review of a re-emerging infectious disease","volume":"49","author":"Staples","year":"2009"},{"key":"b20","series-title":"Emerg Microbes Infect","first-page":"1","article-title":"Aetiology of acute meningoencephalitis in Cambodian children, 2010\u20132013","volume":"6","author":"Horwood","year":"2017"},{"key":"b21","series-title":"Am J Trop Med Hyg","doi-asserted-by":"publisher","first-page":"182","DOI":"10.4269\/ajtmh.16-0013","article-title":"Evaluation of commercially available Chikungunya virus immunoglobulin M detection assays","volume":"95","author":"Johnson","year":"2016"}],"container-title":["The American Journal of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/107\/2\/article-p291.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/107\/2\/article-p291.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/107\/2\/article-p291.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,17]],"date-time":"2022-08-17T13:13:26Z","timestamp":1660742006000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/107\/2\/article-p291.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,17]]},"references-count":21,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.22-0050","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"value":"0002-9637","type":"print"},{"value":"1476-1645","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,17]]}}}