{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,7,20]],"date-time":"2022-07-20T14:42:31Z","timestamp":1658328151237},"reference-count":22,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,6,15]]},"abstract":"<jats:title>ABSTRACT.<\/jats:title>\n<jats:p>Sierra Leone relies heavily on histidine-rich protein 2\u2013based diagnostics for malaria because of the high transmission of <jats:italic>Plasmodium falciparum<\/jats:italic>. During the 2015 recombinant vesicular stomatitis virus (VSV)\u2212Zaire Ebola virus envelope glycoprotein (GP) vaccine trial, 77 participants with asymptomatic <jats:italic>Plasmodium<\/jats:italic> infection were enrolled, with all but four having <jats:italic>P. falciparum<\/jats:italic> malaria. Of the 73 participants with <jats:italic>P. falciparum<\/jats:italic> malaria, one infection (1 of 73, 1.4%; 95% CI, 0.03\u20137.4) showed <jats:italic>P. falciparum<\/jats:italic> with a <jats:italic>pfhrp3<\/jats:italic> single deletion, and two <jats:italic>P. falciparum<\/jats:italic> infections (2 of 73, 2.7%; 95% CI, 0.03\u20139.6) showed <jats:italic>pfhrp2\/pfhrp3<\/jats:italic> dual deletions. This study shows evidence of <jats:italic>pfhrp2-<\/jats:italic> and <jats:italic>pfhrp3<\/jats:italic>-deleted parasites in Freetown, Sierra Leone. Additional studies for more precise estimates of prevalence are warranted.<\/jats:p>","DOI":"10.4269\/ajtmh.22-0073","type":"journal-article","created":{"date-parts":[[2022,6,15]],"date-time":"2022-06-15T15:07:35Z","timestamp":1655305655000},"page":"1667-1669","source":"Crossref","is-referenced-by-count":0,"title":["Low Prevalence of Deletions of the pfhrp2 and pfhrp3 Genes in Plasmodium falciparum Parasites in Freetown, Sierra Leone in 2015"],"prefix":"10.4269","volume":"106","author":[{"given":"Jessica N.","family":"McCaffery","sequence":"first","affiliation":[{"name":"Malaria Branch, Division of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention, Atlanta, Georgia;"},{"name":"Oak Ridge Associated Universities, Oak Ridge, Tennessee;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Curtis S.","family":"Huber","sequence":"additional","affiliation":[{"name":"Malaria Branch, Division of Parasitic Diseases and Malaria, Centers for Disease Control and 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