{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T08:42:25Z","timestamp":1774600945224,"version":"3.50.1"},"reference-count":22,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,8,17]]},"abstract":"<jats:title>ABSTRACT.<\/jats:title>\n<jats:p>Maternal syphilis remains a major contributor to poor pregnancy outcomes. Syphilis point-of-care (POC) tests are now used for pregnancy screening; the effect of screening on outcomes is unclear. We enrolled women presenting to antenatal care (ANC) in a matched cohort study at a single site in Kenya tested by either a syphilis-only or an HIV\/syphilis dual POC test. Syphilis POC-positive women (patients) were matched 1:2 with POC-negative women (control subjects) on gravidity, gestational age, and HIV status, and were monitored through delivery. Syphilis serum testing was performed every 8 weeks. Pregnancy outcomes were assessed up to 1 month after delivery and compared using prevalence ratios. A total of 151 women were enrolled (51 patients and 100 control subjects) at a mean of 22 weeks gestation; 24% were HIV positive and 40% were paucigravid. A positive <jats:italic>Treponema pallidum<\/jats:italic> hemagglutination test was more common among patients (64.7%) than control subjects (11.1%, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). Only two women met the definition for incident syphilis. Pregnancy outcomes were available for 147 women. The prevalence of low birthweight (LBW) was greater among patients (15.2%) than control subjects (5.4%, <jats:italic>P<\/jats:italic>\u2009=\u20090.052). Of the 109 women with concordant syphilis POC and <jats:italic>Treponema pallidum<\/jats:italic> hemagglutination test results at ANC enrollment, LBW prevalence was significantly greater among test-positive (25%) than test-negative (4.9%) women (adjusted prevalence ratio, 5.84; 95% CI, 1.08\u201331.5). Despite treatment with penicillin, latent syphilis at ANC enrollment was associated with a more than 5-fold increased risk of LBW. Alternate implementation strategies for syphilis POC testing may be necessary to realize the potential of ANC syphilis screening to improve pregnancy outcomes.<\/jats:p>","DOI":"10.4269\/ajtmh.22-0083","type":"journal-article","created":{"date-parts":[[2022,7,5]],"date-time":"2022-07-05T13:13:20Z","timestamp":1657026800000},"page":"401-406","source":"Crossref","is-referenced-by-count":2,"title":["Associations between Antenatal Syphilis Test Results and Adverse Pregnancy Outcomes in Western Kenya"],"prefix":"10.4269","volume":"107","author":[{"given":"Jeremiah","family":"Laktabai","sequence":"first","affiliation":[{"name":"Department of Family Medicine, Moi University School of Medicine, Eldoret, Kenya;"},{"name":"Academic Model Providing Access to Healthcare, Moi Teaching and Referral Hospital, Eldoret, Kenya;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victoria L.","family":"Mobley","sequence":"additional","affiliation":[{"name":"Division of Public Health, Department of Health and Human Services, Raleigh, North Carolina;"},{"name":"Department of Epidemiology, UNC Gillings School of Global Public Health, Chapel Hill, North Carolina;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wendy","family":"Prudhomme-O\u2019Meara","sequence":"additional","affiliation":[{"name":"Academic Model Providing Access to Healthcare, Moi Teaching and Referral Hospital, Eldoret, Kenya;"},{"name":"Duke Global Health Institute, Duke University, Durham, North Carolina;"},{"name":"Division of Infectious Diseases, Duke University School of Medicine, Durham, North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steve M.","family":"Taylor","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, UNC Gillings School of Global Public Health, Chapel Hill, North Carolina;"},{"name":"Duke Global Health Institute, Duke University, Durham, North Carolina;"},{"name":"Division of Infectious Diseases, Duke University School of Medicine, Durham, North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2795","reference":[{"key":"b1","series-title":"Bull World Health Organ","doi-asserted-by":"publisher","first-page":"217","DOI":"10.2471\/BLT.12.107623","article-title":"Untreated maternal syphilis and adverse outcomes of pregnancy: a systematic review and meta-analysis","volume":"91","year":"2013"},{"key":"b2","series-title":"PLoS One","doi-asserted-by":"publisher","first-page":"e0211720","DOI":"10.1371\/journal.pone.0211720","article-title":"Global burden of maternal and congenital syphilis and associated adverse birth outcomes: estimates for 2016 and progress since 2012","volume":"14","year":"2019"},{"key":"b3","series-title":"Sex Transm Dis","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1097\/OLQ.0000000000000460","article-title":"Prevalence of curable sexually transmitted infections in pregnant women in low- and middle-income countries from 2010 to 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