{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,5]],"date-time":"2026-07-05T04:16:22Z","timestamp":1783224982296,"version":"3.54.6"},"reference-count":126,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"4_Suppl","license":[{"start":{"date-parts":[[2022,10,11]],"date-time":"2022-10-11T00:00:00Z","timestamp":1665446400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,10,11]]},"abstract":"<jats:title>ABSTRACT.<\/jats:title>\n<jats:p>The 1990s saw the rapid reemergence of malaria in Amazonia, where it remains an important public health priority in South America. The Amazonian International Center of Excellence in Malaria Research (ICEMR) was designed to take a multidisciplinary approach toward identifying novel malaria control and elimination strategies. Based on geographically and epidemiologically distinct sites in the Northeastern Peruvian and Western Brazilian Amazon regions, synergistic projects integrate malaria epidemiology, vector biology, and immunology. The Amazonian ICEMR\u2019s overarching goal is to understand how human behavior and other sociodemographic features of human reservoirs of transmission\u2014predominantly asymptomatically parasitemic people\u2014interact with the major Amazonian malaria vector, <jats:italic>Nyssorhynchus<\/jats:italic> (formerly <jats:italic>Anopheles<\/jats:italic>) <jats:italic>darlingi,<\/jats:italic> and with human immune responses to maintain malaria resilience and continued endemicity in a hypoendemic setting. Here, we will review Amazonian ICEMR\u2019s achievements on the synergies among malaria epidemiology, <jats:italic>Plasmodium-<\/jats:italic>vector interactions, and immune response, and how those provide a roadmap for further research, and, most importantly, point toward how to achieve malaria control and elimination in the Americas.<\/jats:p>","DOI":"10.4269\/ajtmh.22-0127","type":"journal-article","created":{"date-parts":[[2022,10,13]],"date-time":"2022-10-13T21:08:20Z","timestamp":1665695300000},"page":"168-181","source":"Crossref","is-referenced-by-count":17,"title":["Malaria Resilience in South America: Epidemiology, Vector Biology, and Immunology Insights from the Amazonian International Center of Excellence in Malaria Research Network in Peru and Brazil"],"prefix":"10.4269","volume":"107","author":[{"given":"Katherine","family":"Torres","sequence":"first","affiliation":[{"name":"Institute of Tropical Medicine Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Lima, Peru;"},{"name":"Laboratorios de Investigaci\u00f3n y Desarrollo, Facultad de Ciencias y Filosof\u00eda, Universidad Peruana Cayetano Heredia, Lima, Peru;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo U.","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Department of Parasitology, Institute of Biomedical Sciences, University of S\u00e3o Paulo, Sao Paulo, Brazil;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcia C.","family":"Castro","sequence":"additional","affiliation":[{"name":"Department of Global Health and Population, Harvard T. 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