{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T05:54:31Z","timestamp":1789192471747,"version":"build-2803163510"},"reference-count":10,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"4","license":[{"start":{"date-parts":[[2022,10,12]],"date-time":"2022-10-12T00:00:00Z","timestamp":1665532800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,10,12]]},"abstract":"<jats:title>ABSTRACT.<\/jats:title>\n<jats:p>Drug utilization and payment estimates for standard-of-care treatment of schistosomiasis have not been reported previously in the United States. This study estimates the utilization of praziquantel (standard-of-care drug) among patients with schistosomiasis and outpatient payments among those who were treated with praziquantel, and investigates the factors associated with praziquantel use from 2013\u201319 using IBM\u2019s MarketScan<jats:sup>\u00ae<\/jats:sup> Commercial Claims and Encounters database. Claims data showed that only 21% of patients with schistosomiasis diagnoses were treated with praziquantel. The mean total drug payments per patient treated with praziquantel increased from $110 in 2013\u201314 to $612 in 2015\u201318 (<jats:italic>P<\/jats:italic> &lt; 0.01), and use decreased. These factors, including residing in a rural area, having a documented <jats:italic>Schistosoma haematobium<\/jats:italic> infection, or having a first schistosomiasis diagnosis in 2015\u201316, were associated with a decreased likelihood of patients receiving standard-of-care treatment. Policy solutions to exorbitant drug pricing, and better awareness and education among healthcare providers about schistosomiasis\u2014especially those practicing in rural areas with high immigrant populations\u2014are needed.<\/jats:p>","DOI":"10.4269\/ajtmh.22-0254","type":"journal-article","created":{"date-parts":[[2022,8,22]],"date-time":"2022-08-22T13:04:58Z","timestamp":1661173498000},"page":"841-844","source":"Crossref","is-referenced-by-count":1,"title":["Low Use of Standard-of-Care Antiparasitic Drugs and Increased Estimated Outpatient Payments for Treating Schistosomiasis in the United States, 2013\u201319"],"prefix":"10.4269","volume":"107","author":[{"given":"Heesoo","family":"Joo","sequence":"first","affiliation":[{"name":"Division of Global Migration and Quarantine, Centers for Disease Control and Prevention, Atlanta, Georgia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian A.","family":"Maskery","sequence":"additional","affiliation":[{"name":"Division of Global Migration and Quarantine, Centers for Disease Control and Prevention, Atlanta, Georgia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan D.","family":"Alpern","sequence":"additional","affiliation":[{"name":"HealthPartners Institute, Bloomington, Minnesota;"},{"name":"Department of Medicine, University of Minnesota, Minneapolis, Minnesota;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca J.","family":"Chancey","sequence":"additional","affiliation":[{"name":"Division of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention, Atlanta, Georgia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Weinberg","sequence":"additional","affiliation":[{"name":"Division of Global Migration and Quarantine, Centers for Disease Control and Prevention, Atlanta, Georgia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William M.","family":"Stauffer","sequence":"additional","affiliation":[{"name":"Division of Global Migration and Quarantine, Centers for Disease Control and Prevention, Atlanta, Georgia;"},{"name":"Department of Medicine, University of Minnesota, Minneapolis, Minnesota;"},{"name":"Center for Global Health and Social Responsibility, University of Minnesota, Minneapolis, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"b1","series-title":"Nat Rev Dis Primers","first-page":"1","article-title":"Schistosomiasis","volume":"4","year":"2018"},{"key":"b2","series-title":"Clin Pediatr (Phila)","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1177\/000992280604500210","article-title":"Hematuria in children due to schistosomiasis in a nonendemic setting","volume":"45","year":"2006"},{"key":"b3","series-title":"Lancet","doi-asserted-by":"publisher","first-page":"2253","DOI":"10.1016\/S0140-6736(13)61949-2","article-title":"Human schistosomiasis","volume":"383","year":"2014"},{"key":"b4","year":"2020"},{"key":"b5","year":"2021"},{"key":"b6","series-title":"Pediatr Pulmonol","doi-asserted-by":"publisher","first-page":"1611","DOI":"10.1002\/ppul.24178","article-title":"Healthcare expenditures for privately insured US patients with cystic fibrosis, 2010\u20132016","volume":"53","year":"2018"},{"key":"b7","series-title":"Am J Trop Med Hyg","doi-asserted-by":"publisher","first-page":"1851","DOI":"10.4269\/ajtmh.20-1452","article-title":"The effect of drug pricing on outpatient payments and treatment for three soil-transmitted helminth infections in the United States, 2010\u20132017","volume":"104","author":"Joo","year":"2021"},{"key":"b8","series-title":"JAMA Netw Open","first-page":"1","article-title":"Increases in anti-infective drug prices, subsequent prescribing, and outpatient costs","volume":"4","year":"2021"},{"key":"b9","series-title":"Open Public Health J","doi-asserted-by":"publisher","first-page":"11","DOI":"10.2174\/1874944500902010011","article-title":"The use of claims data in healthcare research","volume":"2","year":"2009"},{"key":"b10","year":"2021"}],"container-title":["The American Journal of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/107\/4\/article-p841.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/107\/4\/article-p841.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/107\/4\/article-p841.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,12]],"date-time":"2022-10-12T16:49:08Z","timestamp":1665593348000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/107\/4\/article-p841.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,12]]},"references-count":10,"journal-issue":{"issue":"4"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.22-0254","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"value":"0002-9637","type":"print"},{"value":"1476-1645","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,12]]}}}