{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T13:23:28Z","timestamp":1776777808719,"version":"3.51.2"},"reference-count":19,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,9,14]]},"abstract":"<jats:title>ABSTRACT.<\/jats:title>\n<jats:p>Melioidosis has a highly variable presentation. Almost any organ can be involved, although an antemortem diagnosis of acute suppurative thyroiditis (AST) has not, to our knowledge, been described previously. A 68-year-old Australian male with poorly controlled type 2 diabetes mellitus presented with fever, odynophagia, and thyroid function tests that were consistent with hyperthyroidism. Imaging demonstrated a lung abscess and an enlarged thyroid gland with three nodules. Blood cultures and fine-needle aspiration of the thyroid nodules grew <jats:italic>Burkholderia pseudomallei<\/jats:italic>. He received intravenous ceftazidime with concurrent oral trimethoprim\/sulfamethoxazole (TMP\/SMX) for 4 weeks followed by high-dose oral TMP\/SMX for a further 3 months and made a complete recovery. Acute suppurative thyroiditis is an uncommon cause of hyperthyroidism and thyroid aspirates are not commonly sent for bacterial culture. The case highlights the need to consider AST in patients presenting with a hyperthyroid state and disseminated infection. It also demonstrates that in a case of disseminated melioidosis any symptom may be a clue to underlying metastatic infection.<\/jats:p>","DOI":"10.4269\/ajtmh.22-0277","type":"journal-article","created":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T12:56:28Z","timestamp":1659358588000},"page":"581-584","source":"Crossref","is-referenced-by-count":2,"title":["Case Report: Disseminated Burkholderia pseudomallei with Acute Suppurative Thyroiditis and Abscess Formation"],"prefix":"10.4269","volume":"107","author":[{"given":"Julian","family":"Harris","sequence":"first","affiliation":[{"name":"Cairns Hospital, Cairns, Queensland, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon","family":"Smith","sequence":"additional","affiliation":[{"name":"Cairns Hospital, Cairns, Queensland, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soong Zheng","family":"Ng","sequence":"additional","affiliation":[{"name":"Cairns Hospital, Cairns, Queensland, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashim","family":"Sinha","sequence":"additional","affiliation":[{"name":"Cairns Hospital, Cairns, Queensland, Australia;"},{"name":"James Cook University, Cairns, Queensland, Australia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josh","family":"Hanson","sequence":"additional","affiliation":[{"name":"Cairns Hospital, Cairns, Queensland, Australia;"},{"name":"The Kirby Institute, University of New South Wales, Sydney, New South Wales, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2795","reference":[{"key":"b1","series-title":"Emerg Infect Dis","doi-asserted-by":"publisher","first-page":"3119","DOI":"10.3201\/eid2712.211302","article-title":"Increased incidence of melioidosis in Far North Queensland, Queensland, Australia, 1998\u20132019","volume":"27","year":"2021"},{"key":"b2","series-title":"PLoS Negl Trop Dis","doi-asserted-by":"publisher","first-page":"e0009704","DOI":"10.1371\/journal.pntd.0009704","article-title":"Comparative clinical characteristics and outcomes of patients with community acquired bacteremia caused by Escherichia coli, Burkholderia pseudomallei and Staphylococcus aureus: a prospective observational study (Ubon-sepsis)","volume":"15","year":"2021"},{"key":"b3","series-title":"PLoS Negl Trop Dis","doi-asserted-by":"publisher","first-page":"e0008659","DOI":"10.1371\/journal.pntd.0008659","article-title":"2020 Review and revision of the 2015 Darwin melioidosis treatment guideline; 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