{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T10:36:52Z","timestamp":1778323012453,"version":"3.51.4"},"reference-count":23,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,12,14]]},"abstract":"<jats:title>ABSTRACT.<\/jats:title>\n<jats:p>Drug-resistant tuberculosis (DR-TB) continues to be a serious public health problem. The objective of this study was to evaluate the sociodemographic, radiological, clinical, and outcome characteristics and assess the determinants of unfavorable outcomes in DR-TB. The descriptive-analytical study was carried out in a reference outpatient clinic in Rio de Janeiro, Brazil, among DR-TB cases that received treatment between February 2016 and October 2020, using descriptive statistics, \u03c7<jats:sup>2<\/jats:sup> test, and logistic regression multivariate. Of the 148 cases, 12.2% were resistant to rifampicin, 12.2% were resistant to isoniazid, 18.2% were polyresistant, 56.1% multidrug resistant, and 1.3% were extensively drug resistant. Most of the patients were men, aged up to 44 years, with brown or black skin, having up to 8 years of schooling, unemployed or working in the informal economy, and of low income. Presenting with acquired resistance or positive sputum smear microscopy in the diagnosis, taking more than four drugs, and being unemployed were associated with unfavorable outcomes. Having no income or acquired resistance doubled the chances of unfavorable outcomes. There was a high proportion of unfavorable outcomes, thereby highlighting the need to concentrate efforts on planning and executing public policies that include the severity of DR-TB and its risk factors.<\/jats:p>","DOI":"10.4269\/ajtmh.22-0294","type":"journal-article","created":{"date-parts":[[2022,10,31]],"date-time":"2022-10-31T16:13:46Z","timestamp":1667232826000},"page":"1295-1301","source":"Crossref","is-referenced-by-count":5,"title":["Sociodemographic and Clinical Factors Associated with Treatment Outcomes for Drug-resistant Tuberculosis"],"prefix":"10.4269","volume":"107","author":[{"given":"Ana Carolina","family":"de Oliveira Jeronymo Neves","sequence":"first","affiliation":[{"name":"Medical School and Institute of Thorax Diseases of the Federal University of Rio de Janeiro, Rio de Janeiro, Brazil;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Paula","family":"Gomes dos Santos","sequence":"additional","affiliation":[{"name":"Medical School and Institute of Thorax Diseases of the Federal University of Rio de Janeiro, Rio de Janeiro, Brazil;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Regielle Luiza","family":"de Medeiros","sequence":"additional","affiliation":[{"name":"Medical School and Institute of Thorax Diseases of the Federal University of Rio de Janeiro, Rio de Janeiro, Brazil;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana J\u00falia","family":"de Oliveira Jeronymo","sequence":"additional","affiliation":[{"name":"Federal University of Juiz de Fora, Minas Gerais, Brazil;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guilherme","family":"Coelho Neves","sequence":"additional","affiliation":[{"name":"Federal University of Juiz de Fora, Minas Gerais, Brazil;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabela Neves","family":"de Almeida","sequence":"additional","affiliation":[{"name":"Federal University of Ouro Preto, Minas Gerais, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernanda","family":"Carvalho de Queiroz Mello","sequence":"additional","affiliation":[{"name":"Medical School and Institute of Thorax Diseases of the Federal University of Rio de Janeiro, Rio de Janeiro, Brazil;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Afr\u00e2nio","family":"Lineu Kritski","sequence":"additional","affiliation":[{"name":"Medical School and Institute of Thorax Diseases of the Federal University of Rio de Janeiro, Rio de Janeiro, Brazil;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2795","reference":[{"key":"b1","series-title":"Global Tuberculosis Report 2021","year":"2021"},{"key":"b2","series-title":"Euro Surveill","first-page":"1","article-title":"Isoniazid (INH) mono-resistance and tuberculosis (TB) treatment success: analysis of European surveillance data, 2002 to 2014","volume":"24","author":"Karo","year":"2019"},{"key":"b3","year":"2021"},{"key":"b4","series-title":"PLoS One","first-page":"1","article-title":"Predictive factors for unfavourable treatment in MDR-TB and XDR-TB patients in Rio de Janeiro State, Brazil, 2000\u20132016","volume":"14","author":"Bhering","year":"2019"},{"key":"b5","series-title":"Epidemiol Serv Saude","first-page":"1","article-title":"Special Tuberculosis Treatment Information System (SITE-TB) in Brazil: background, description and perspectives","volume":"28","author":"Bartholomay","year":"2019"},{"key":"b6","series-title":"Lei n\u00b0 8.080, de 19 de setembro de 1990. 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