{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,11,17]],"date-time":"2022-11-17T05:48:58Z","timestamp":1668664138156},"reference-count":16,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"5","license":[{"start":{"date-parts":[[2022,11,14]],"date-time":"2022-11-14T00:00:00Z","timestamp":1668384000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,11,14]]},"abstract":"<jats:title>ABSTRACT.<\/jats:title>\n<jats:p>There are scarce data about the glucose-6-phosphate dehydrogenase (<jats:italic>G6PD)<\/jats:italic> variants in Haiti to guide public health guidelines. In this study, we investigated the prevalence of the <jats:italic>G6PD<\/jats:italic> mutations related to the A- variant. We found an allelic frequency of 35.8% for the A376G mutation and of 12.2% for the G202A mutation. We also found a novel C370T mutation concomitant with the A376G mutation in one study participant. The G680T and T968C mutations were not found. The G6PD deficient variant A<jats:sup>202<\/jats:sup> (A376G and G202A mutations) has appreciable prevalence in Haiti (16.6%), consideration is warranted when using drugs such as primaquine, which may trigger hemolytic anemia among G6PD-deficient people.<\/jats:p>","DOI":"10.4269\/ajtmh.22-0375","type":"journal-article","created":{"date-parts":[[2022,10,3]],"date-time":"2022-10-03T14:40:54Z","timestamp":1664808054000},"page":"1142-1144","source":"Crossref","is-referenced-by-count":0,"title":["Glucose-6-phosphate Dehydrogenase (G6PD) A-Variant Frequency and Novel Polymorphism in Haiti"],"prefix":"10.4269","volume":"107","author":[{"given":"Jeanne P","family":"Vincent","sequence":"first","affiliation":[{"name":"National Center for Global Health and Medicine, Tokyo, Japan;"},{"name":"Institut Pasteur, Paris, France;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandre V","family":"Existe","sequence":"additional","affiliation":[{"name":"Laboratoire National de Sant\u00e9 Publique, Port-au-Prince, Haiti"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kanako","family":"Komaki-Yasuda","sequence":"additional","affiliation":[{"name":"National Center for Global Health and Medicine, Tokyo, Japan;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacques","family":"Boncy","sequence":"additional","affiliation":[{"name":"Laboratoire National de Sant\u00e9 Publique, Port-au-Prince, Haiti"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeyuki","family":"Kano","sequence":"additional","affiliation":[{"name":"National Center for Global Health and Medicine, Tokyo, Japan;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2795","reference":[{"key":"b1","series-title":"Blood","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1182\/blood.V54.5.961.961","article-title":"Genetics of red cells and susceptibility to 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