{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T18:52:26Z","timestamp":1771008746640,"version":"3.50.1"},"reference-count":22,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,1,11]]},"abstract":"<jats:title>ABSTRACT.<\/jats:title>\n<jats:p>Chronic pulmonary aspergillosis (CPA) is divided into five subtypes. The diagnosis of CPA is complicated due to poor sensitivity of the laboratory tests. Diagnostic performance of different antigen, serological, and microbiological methods in subtypes of CPA is unknown. The purpose of this study was to evaluate the diagnostic performance in different subtypes of CPA. A total of 91 participants with CPA were included, and the study was performed at Hospital das Cl\u00ednicas of University of S\u00e3o Paulo. Bronchoalveolar lavage galactomannan (73%, 11\/15), serology by immunodiffusion test (81%, 61\/75), and histology (78%, 39\/50) had the best sensitivity. The counterimmunoelectrophoresis (CIE) titers had a significant statistical difference between the CPA subtypes (<jats:italic>P<\/jats:italic> &lt; 0.001), in which the forms chronic fibrosing pulmonary aspergillosis (CFPA) and subacute invasive aspergillosis (SAIA) had higher titers: 1\/64 (interquartile range [IQR]: 1\/32\u20131\/256) and 1\/64 (1\/32\u20131\/128). C-reactive protein generally presented lower values (median 15 mg\/L, IQR: 6\u201333), with higher values in SAIA and lower values for <jats:italic>Aspergillus<\/jats:italic> nodule. Overall, we found a low diagnostic sensitivity of current tests. Regarding the CPA subtypes, we did not find great differences in the performance of the tests, but it is observed that the inflammatory markers and CIE titers tend to be higher in forms of the more extensive lung parenchyma involvement, such as SAIA and CFPA.<\/jats:p>","DOI":"10.4269\/ajtmh.22-0412","type":"journal-article","created":{"date-parts":[[2022,11,30]],"date-time":"2022-11-30T21:17:37Z","timestamp":1669843057000},"page":"22-26","source":"Crossref","is-referenced-by-count":8,"title":["Sensitivity of Antigen, Serology, and Microbiology Assays for Diagnosis of the Subtypes of Chronic Pulmonary Aspergillosis at a Teaching Hospital in S\u00e3o Paulo, Brazil"],"prefix":"10.4269","volume":"108","author":[{"given":"V\u00edtor Falc\u00e3o","family":"de Oliveira","sequence":"first","affiliation":[{"name":"Department of Infectious and Parasitic Diseases of Hospital das Cl\u00ednicas, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joshua Ara\u00fajo","family":"Viana","sequence":"additional","affiliation":[{"name":"Department of Radiology of Hospital das Cl\u00ednicas, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcio Valente Yamada","family":"Sawamura","sequence":"additional","affiliation":[{"name":"Department of Radiology of Hospital das Cl\u00ednicas, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriana Satie Gon\u00e7alves Kono","family":"Magri","sequence":"additional","affiliation":[{"name":"Department of Infectious and Parasitic Diseases of Hospital das Cl\u00ednicas, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andre","family":"Nathan Costa","sequence":"additional","affiliation":[{"name":"Department of Pneumology of Hospital das Cl\u00ednicas, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edson","family":"Abdala","sequence":"additional","affiliation":[{"name":"Department of Infectious and Parasitic Diseases of Hospital das Cl\u00ednicas, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro Wasum","family":"Mariani","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery of Hospital das Cl\u00ednicas, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gil","family":"Benard","sequence":"additional","affiliation":[{"name":"Laboratory of Medical Mycology (LIM-53), Instituto de Medicina Tropical e Division of Clinical Dermatology, Hospital das Cl\u00ednicas, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcello Mihailenko","family":"Chaves Magri","sequence":"additional","affiliation":[{"name":"Department of Infectious and Parasitic Diseases of Hospital das Cl\u00ednicas, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2795","reference":[{"key":"b1","series-title":"Chest","doi-asserted-by":"publisher","first-page":"1988","DOI":"10.1378\/chest.121.6.1988","article-title":"The clinical spectrum of pulmonary aspergillosis","volume":"121","author":"Soubani","year":"2002"},{"key":"b2","series-title":"Med Mycol","doi-asserted-by":"publisher","first-page":"S104","DOI":"10.1093\/mmy\/myy070","article-title":"CPAnet. 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