{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T18:03:48Z","timestamp":1764785028125},"reference-count":14,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,1,11]]},"abstract":"<jats:title>ABSTRACT.<\/jats:title>\n<jats:p><jats:italic>Pythium insidiosum<\/jats:italic> is a parasitic oomycete that can cause keratitis and closely resembles fungus, both clinically and morphologically. It requires a trained microbiologist for its differentiation from fungal filaments and has poor response to antifungal therapy. We present a case of primary isolation of the organism from the vitreous cavity in a case of endophthalmitis. The infection spread quickly and involved all the ocular tissues. The eye had poor visual outcome despite a sequence of rapidly completed retinal and corneal surgeries along with initiation of anti-<jats:italic>Pythium<\/jats:italic> therapy.<\/jats:p>","DOI":"10.4269\/ajtmh.22-0441","type":"journal-article","created":{"date-parts":[[2022,12,12]],"date-time":"2022-12-12T15:31:14Z","timestamp":1670859074000},"page":"27-30","source":"Crossref","is-referenced-by-count":4,"title":["Case Report: Poor Outcome Despite Aggressive Management in Pythium insidiosum Endophthalmitis"],"prefix":"10.4269","volume":"108","author":[{"given":"David","family":"Aggarwal","sequence":"first","affiliation":[{"name":"Anant Bajaj Retina Institute, L V Prasad Eye Institute (LVPEI), Hyderabad, India;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanchita","family":"Mitra","sequence":"additional","affiliation":[{"name":"Jhaveri Microbiology Centre, LVPEI, Hyderabad, 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