{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T11:24:27Z","timestamp":1789125867853,"version":"build-2803163510"},"reference-count":49,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"1","license":[{"start":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T00:00:00Z","timestamp":1673395200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,1,11]]},"abstract":"<jats:title>ABSTRACT.<\/jats:title>\n<jats:p>Coronavirus disease (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) poses serious global public health problems. Characterization of the immune response, particularly antibodies to SARS-CoV-2, is important for establishing vaccine strategies. The purpose of this study was to evaluate longitudinally the kinetics of anti-SARS-CoV-2 antibodies against spike protein (S1) for up to 3 months in a cohort of 169 COVID-19 patients. We enrolled COVID-19 patients at two regional hospitals in Casablanca, Morocco, between March and September 2021. Blood samples were collected and N-specific IgM and S-specific IgG levels were measured by a commercial Euroimmun ELISA. IgM antibodies were assessed 2\u20135 (D00), 9\u201312 (D07), 17\u201320 (D15), and 32\u201337 (D30) days after symptom onset; IgG antibodies were assessed at these time points plus 60 (D60) and 90 (D90) days after symptom onset. We found that at 3 months after symptom onset, 79% of patients had detectable SARS-CoV-2-specific IgG antibodies, whereas their IgM seropositivity was 19% by 1 month after symptom onset. The IgM level decreased to 0.34 (interquartile range [IQR] 0.19\u20130.92) at 1 month after symptom onset, whereas the IgG level peaked at D30 (3.10; IQR 1.83\u20135.64) and remained almost stable at D90 (2.95; IQR 1.52\u20135.19). IgG levels were significantly higher in patients older than 50 years than in those younger than 50 at all follow-up time points (<jats:italic>P<\/jats:italic> &lt; 0.05). Statistical analysis showed no significant difference in median anti-S1 antibody levels among infected patients based on gender or comorbidities. This study provides information on the longevity of anti-SARS-CoV-2 IgM and IgG antibodies in COVID-19 patients.<\/jats:p>","DOI":"10.4269\/ajtmh.22-0448","type":"journal-article","created":{"date-parts":[[2022,12,12]],"date-time":"2022-12-12T15:31:05Z","timestamp":1670859065000},"page":"145-154","source":"Crossref","is-referenced-by-count":26,"title":["Kinetics of SARS-CoV-2 IgM and IgG Antibodies 3 Months after COVID-19 Onset in Moroccan Patients"],"prefix":"10.4269","volume":"108","author":[{"given":"Najlaa","family":"Assaid","sequence":"first","affiliation":[{"name":"Service de Parasitologie et des Maladies Vectorielles, Institut Pasteur du Maroc, Casablanca, Morocco;"},{"name":"Biochemistry, Biotechnology and Immunophysiopathology Research Team, Health and Environment Laboratory, A\u00efn Chock Faculty of Sciences, University of Hassan II Casablanca, Casablanca, 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