{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T21:18:50Z","timestamp":1790889530438,"version":"4.1.0"},"reference-count":42,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"4","license":[{"start":{"date-parts":[[2023,4,5]],"date-time":"2023-04-05T00:00:00Z","timestamp":1680652800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,4,5]]},"abstract":"<jats:title>ABSTRACT.<\/jats:title>\n<jats:p>Uganda reported cases of Rift Valley fever virus (RVFV) for the first time in almost 50 years in 2016, following an outbreak of Rift Valley fever (RVF) that caused four human infections, two of which resulted in death. Subsequent outbreak investigation serosurveys found high seroprevalence of IgG antibodies without evidence of acute infection or IgM antibodies, suggesting the possibility of undetected RVFV circulation prior to the outbreak. After the 2016 outbreak investigation, a serosurvey was conducted in 2017 among domesticated livestock herds across Uganda. Sampling data were incorporated into a geostatistical model to estimate RVF seroprevalence among cattle, sheep, and goats. Variables resulting in the best fit to RVF seroprevalence sampling data included annual variability in monthly precipitation and enhanced vegetation index, topographic wetness index, log human population density percent increase, and livestock species. Individual species RVF seroprevalence prediction maps were created for cattle, sheep, and goats, and a composite livestock prediction was created based on the estimated density of each species across the country. Seroprevalence was greater in cattle compared with sheep and goats. Predicted seroprevalence was greatest in the central and northwestern quadrant of the country, surrounding Lake Victoria, and along the Southern Cattle Corridor. We identified areas that experienced conditions conducive to potential increased RVFV circulation in 2021 in central Uganda. An improved understanding of the determinants of RVFV circulation and locations with high probability of elevated RVF seroprevalence can guide prioritization of disease surveillance and risk mitigation efforts.<\/jats:p>","DOI":"10.4269\/ajtmh.22-0555","type":"journal-article","created":{"date-parts":[[2023,3,6]],"date-time":"2023-03-06T13:47:09Z","timestamp":1678110429000},"page":"712-721","source":"Crossref","is-referenced-by-count":9,"title":["Geostatistical Modeling and Prediction of Rift Valley Fever Seroprevalence among Livestock in Uganda"],"prefix":"10.4269","volume":"108","author":[{"given":"Carson","family":"Telford","sequence":"first","affiliation":[{"name":"Viral Special Pathogens Branch, Centers for Disease Control and Prevention, Atlanta, Georgia;"},{"name":"Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luke","family":"Nyakarahuka","sequence":"additional","affiliation":[{"name":"Uganda Virus Research Institute;"},{"name":"Department of Biosecurity, Ecosystems and Veterinary Public Health, Makerere University, Kampala, Uganda;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lance","family":"Waller","sequence":"additional","affiliation":[{"name":"Rollins School of Public Health, Emory University, Atlanta, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uriel","family":"Kitron","sequence":"additional","affiliation":[{"name":"Rollins School of Public Health, Emory University, Atlanta, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trevor","family":"Shoemaker","sequence":"additional","affiliation":[{"name":"Viral Special Pathogens Branch, Centers for Disease Control and Prevention, Atlanta, Georgia;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"b1","series-title":"J Pathol Bacteriol","first-page":"545","article-title":"Enzootic hepatitis or Rift Valley fever; an un-described virus disease of sheep, cattle and man from East Africa","volume":"34","author":"Daubney","year":"1931"},{"key":"b2","series-title":"J Am Mosq Control Assoc","first-page":"502","article-title":"Potential for North American mosquitoes to transmit Rift Valley fever virus","volume":"24","author":"Turell","year":"2008"},{"key":"b3","series-title":"Am J Trop Med Hyg","first-page":"52","article-title":"An assessment of the regional and national socio-economic impacts of the 2007 Rift Valley fever outbreak in Kenya","volume":"83","author":"Rich","year":"2010"},{"key":"b4","year":"2020"},{"key":"b5","series-title":"PLoS Negl Trop Dis","first-page":"e0006412","article-title":"Prevalence and risk factors of Rift Valley fever in humans and animals from Kabale district in Southwestern Uganda, 2016","volume":"12","author":"Nyakarahuka","year":"2016"},{"key":"b6","series-title":"Am J Trop Med Hyg","first-page":"22","article-title":"Epidemiologic and clinical aspects of a Rift Valley fever outbreak in humans in Tanzania, 2007","volume":"83","author":"Mohamed","year":"2010"},{"key":"b7","series-title":"Trans R Soc Trop Med Hyg","first-page":"630","article-title":"Epidemic Rift Valley fever in Egypt: observations of the spectrum of human illness","volume":"73","author":"Laughlin","year":"1979"},{"key":"b8","series-title":"MMWR Morb Mortal Wkly Rep","first-page":"1200","article-title":"Rift Valley fever response: Kabale District, Uganda, March 2016","volume":"65","author":"de St. Maurice","year":"2016"},{"key":"b9","series-title":"Epidemiol Infect","first-page":"197","article-title":"Rift Valley fever virus (family Bunyaviridae, genus Phlebovirus): isolations from Diptera collected during an inter-epizootic period in Kenya","volume":"95","author":"Linthicum","year":"1985"},{"key":"b10","series-title":"Proc Natl Acad Sci USA","first-page":"955","article-title":"Prediction of a Rift Valley fever outbreak","volume":"106","author":"Anyamba","year":"2009"},{"key":"b11","series-title":"J Med Entomol","first-page":"102","article-title":"Vector competence of selected African mosquito (Diptera: Culicidae) species for Rift Valley fever virus","volume":"45","author":"Turell","year":"2008"},{"key":"b12","series-title":"Science","first-page":"397","article-title":"Climate and satellite indicators to forecast Rift Valley fever epidemics in Kenya","volume":"285","author":"Linthicum","year":"1999"},{"key":"b13","series-title":"Front Public Health","first-page":"169","article-title":"Recent outbreaks of Rift Valley fever in East Africa and the Middle East","volume":"2","author":"Himeidan","year":"2014"},{"key":"b14","series-title":"PLoS One","first-page":"e0144570","article-title":"Predictive factors and risk mapping for Rift Valley fever epidemics in Kenya","volume":"11","author":"Munyua","year":"2016"},{"key":"b15","series-title":"Philos Trans R Soc Lond B Biol Sci","first-page":"20160165","article-title":"Spatial, seasonal and climatic predictive models of Rift Valley fever disease across Africa","volume":"372","author":"Redding","year":"2017"},{"key":"b16","series-title":"Antiviral Res","first-page":"104692","article-title":"Mechanisms of inter-epidemic maintenance of Rift Valley fever phlebovirus","volume":"174","author":"Rissmann","year":"2020"},{"key":"b17","series-title":"Am J Trop Med Hyg","first-page":"659","article-title":"First laboratory-confirmed outbreak of human and animal Rift Valley fever virus in Uganda in 48 years","volume":"100","author":"Shoemaker","year":"2019"},{"key":"b18","series-title":"J Environ Public Health","first-page":"8881191","article-title":"Sporadic Rift Valley fever outbreaks in humans and animals in Uganda, October 2017\u2013January 2018","volume":"2021","author":"Birungi","year":"2021"},{"key":"b19","series-title":"PLoS Negl Trop Dis","first-page":"e0006627","article-title":"Systematic literature review of Rift Valley fever virus seroprevalence in livestock, wildlife and humans in Africa from 1968 to 2016","volume":"12","author":"Clark","year":"2018"},{"key":"b20","author":"Nyakarahuka","year":"2017"},{"key":"b21","series-title":"NPJ Vaccines","first-page":"1","article-title":"Rift Valley fever virus vaccination induces long-lived, antigen-specific human T cell responses","volume":"5","author":"Harmon","year":"2020"},{"key":"b22","series-title":"J Appl Meteorol Climatol","first-page":"588","article-title":"African rainfall climatology version 2 for famine early warning systems","volume":"52","author":"Novella","year":"2013"},{"key":"b23","author":"Didan","year":"2015"},{"key":"b24","author":"Sulla-Menashe","year":"2019"},{"key":"b25","series-title":"Soil Use and Mgmt","first-page":"124","article-title":"Harmonized soil profile data for applications at global and continental scales: updates to the WISE database","volume":"25","author":"Batjes","year":"2009"},{"key":"b26","series-title":"Sci Data","first-page":"1","article-title":"Global distribution data for cattle, buffaloes, horses, sheep, goats, pigs, chickens and ducks in 2010","volume":"5","author":"Gilbert","year":"2018"},{"key":"b27","year":"2017"},{"key":"b28","series-title":"Sci Data","first-page":"1","article-title":"High resolution global gridded data for use in population studies","volume":"4","author":"Lloyd","year":"2017"},{"key":"b29","series-title":"Sci Data","first-page":"1","article-title":"A land data assimilation system for sub-Saharan Africa food and water security applications","volume":"4","author":"McNally","year":"2017"},{"key":"b30","year":"2020"},{"key":"b31","series-title":"Hydrol Earth Syst Sci","first-page":"101","article-title":"On the calculation of the topographic wetness index: evaluation of different methods based on field observations","volume":"10","author":"S\u00f6rensen","year":"2006"},{"key":"b32","series-title":"Proc Biol Sci","first-page":"20182351","article-title":"Predictive analysis across spatial scales links zoonotic malaria to deforestation","volume":"286","author":"Brock","year":"2019"},{"key":"b33","series-title":"Zoonoses Public Health","first-page":"747","article-title":"Preventing the cross-border spread of zoonotic diseases: multisectoral community engagement to characterize animal mobility: Uganda, 2020","volume":"68","author":"Medley","year":"2021"},{"key":"b34","series-title":"J R Stat Soc Ser C Appl Stat","first-page":"299","article-title":"Model-based geostatistics","volume":"47","author":"Diggle","year":"1998"},{"key":"b35","series-title":"J R Soc Interface","first-page":"20210104","article-title":"Model building and assessment of the impact of covariates for disease prevalence mapping in low-resource settings: to explain and to predict","volume":"18","author":"Giorgi","year":"2021"},{"key":"b36","series-title":"J Stat Softw","first-page":"1","article-title":"PrevMap: an R package for prevalence mapping","volume":"78","author":"Giorgi","year":"2017"},{"key":"b37","series-title":"Model-Based Geostatistics for Global Public Health: Methods and Applications","author":"Diggle","year":"2019"},{"key":"b38","year":"2023"},{"key":"b39","series-title":"Epidemiol Infect","first-page":"1261","article-title":"Prevalence of antibodies against Rift Valley fever virus in Kenyan wildlife","volume":"136","author":"Evans","year":"2008"},{"key":"b40","year":"2009"},{"key":"b41","series-title":"Am J Trop Med Hyg","first-page":"95","article-title":"Larval habitat dynamics and diversity of Culex mosquitoes in rice agro-ecosystem in Mwea, Kenya","volume":"76","author":"Muturi","year":"2007"},{"key":"b42","year":"2019"}],"container-title":["The American Journal of Tropical Medicine and 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