{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T10:55:24Z","timestamp":1696503324294},"reference-count":67,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,10,4]]},"abstract":"<jats:title>ABSTRACT.<\/jats:title>\n<jats:p>Dengue is the most important arthropod-borne viral infection of humans. However, its viral pathogenesis is still unknown. The information collected from dengue fatal cases is crucial for understanding the complex interactions between virulence and host factors. This study aimed to establish possible associations between the clinical characteristics, histopathological changes, replication, and tissue location of viral serotypes in dengue fatal cases. Clinical and histopathological characterizations, antigen localization in tissue, and detection of the infecting serotype and replication using real-time polymerase chain reaction were all performed on the dengue fatal cases. The majority of the cases involved people under the age of 20. Bleeding (48.3%), abdominal pain (44.8%), myalgia (52.9%), and headache (48.3%) were the most common clinical manifestations in the cases. There was multiorgan pathology, with histopathological changes primarily in the liver, spleen, and lung. Similarly, the viral antigen was found primarily in these organs; however, there were no associations between tissue changes, viral location, infecting serotypes, and replication processes. Dengue infection should be considered a multiorgan disease, the outcome of which is possibly not associated with the infecting viral serotype.<\/jats:p>","DOI":"10.4269\/ajtmh.22-0587","type":"journal-article","created":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T14:57:33Z","timestamp":1692629853000},"page":"908-916","source":"Crossref","is-referenced-by-count":0,"title":["Multisystem Failure in Fatal Dengue: Associations between the Infectious Viral Serotype and Clinical and Histopathological Findings"],"prefix":"10.4269","volume":"109","author":[{"given":"Jorge","family":"Rivera","sequence":"first","affiliation":[{"name":"Grupo de Morfolog\u00eda Celular, Direcci\u00f3n de Investigaci\u00f3n en Salud P\u00fablica, Instituto Nacional de Salud, Bogot\u00e1, Colombia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aura Caterine","family":"Rengifo","sequence":"additional","affiliation":[{"name":"Grupo de Morfolog\u00eda Celular, Direcci\u00f3n de Investigaci\u00f3n en Salud P\u00fablica, Instituto Nacional de Salud, Bogot\u00e1, Colombia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diego","family":"Alvarez-D\u00edaz","sequence":"additional","affiliation":[{"name":"Grupo de Morfolog\u00eda Celular, Direcci\u00f3n de Investigaci\u00f3n en Salud P\u00fablica, Instituto Nacional de Salud, Bogot\u00e1, Colombia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edgar","family":"Parra","sequence":"additional","affiliation":[{"name":"Grupo de Patolog\u00eda, Direcci\u00f3n de Redes en Salud P\u00fablica, Instituto Nacional de Salud, Bogot\u00e1, Colombia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9","family":"Usme-Ciro","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n en Salud para el Tr\u00f3pico, Facultad de Medicina, Universidad Cooperativa de Colombia, Santa Marta, Colombia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaime","family":"Castellanos","sequence":"additional","affiliation":[{"name":"Grupo Investigaciones B\u00e1sicas y Aplicadas en Odontolog\u00eda (IBAPO), Facultad de Odontolog\u00eda, Universidad Nacional de Colombia, Bogot\u00e1, Colombia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Myriam","family":"Velandia","sequence":"additional","affiliation":[{"name":"Instituto de Virolog\u00eda, Universidad El Bosque, Bogot\u00e1, Colombia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katherine","family":"Laiton-Donato","sequence":"additional","affiliation":[{"name":"Grupo de Virolog\u00eda, Direcci\u00f3n de Redes en Salud P\u00fablica, Instituto Nacional de Salud, Bogot\u00e1, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ang\u00e9lica","family":"Rico","sequence":"additional","affiliation":[{"name":"Grupo de Virolog\u00eda, Direcci\u00f3n de Redes en Salud P\u00fablica, Instituto Nacional de Salud, Bogot\u00e1, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisseth","family":"Pardo","sequence":"additional","affiliation":[{"name":"Grupo de Virolog\u00eda, Direcci\u00f3n de Redes en Salud P\u00fablica, Instituto Nacional de Salud, Bogot\u00e1, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Leonor","family":"Caldas","sequence":"additional","affiliation":[{"name":"Grupo de Morfolog\u00eda Celular, Direcci\u00f3n de Investigaci\u00f3n en Salud P\u00fablica, Instituto Nacional de Salud, Bogot\u00e1, Colombia;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2795","reference":[{"key":"b1","series-title":"Nat Microbiol","first-page":"1508","article-title":"The current and future global distribution and population at risk of dengue","volume":"4","author":"Messina","year":"2019"},{"key":"b2","series-title":"Nature","first-page":"504","article-title":"The global 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