{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T18:15:47Z","timestamp":1763748947232},"reference-count":20,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"6","license":[{"start":{"date-parts":[[2023,6,7]],"date-time":"2023-06-07T00:00:00Z","timestamp":1686096000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,6,7]]},"abstract":"<jats:title>ABSTRACT.<\/jats:title>\n<jats:p>In 2018, a mass drug administration (MDA) campaign for malaria elimination was piloted in Haiti. The pilot treated 36,338 people with sulfadoxine-pyrimethamine (SP) and primaquine; no severe adverse events were detected. In 2020, another MDA campaign using the same medications was implemented to mitigate an upsurge in malaria cases during the COVID-19 pandemic. Four cases of Stevens\u2013Johnson syndrome (SJS) were identified among the 42,249 people who took the medications. Three of these individuals required hospitalization; all survived. In addition to SP ingestion, an investigation of potential causes for increased SJS cases identified that all four cases had human leukocyte antigens A*29 and\/or B*44:03, another known risk factor for SJS. Additionally, three of the four case individuals had antibodies to SARS-CoV-2, and the fourth may have been exposed around the same time. These findings raise the possibility that recent SARS-CoV-2 infection may have contributed to the increased risk for SJS associated with SP exposure during the 2020 campaign.<\/jats:p>","DOI":"10.4269\/ajtmh.22-0625","type":"journal-article","created":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T19:29:58Z","timestamp":1682969398000},"page":"1140-1144","source":"Crossref","is-referenced-by-count":5,"title":["Investigation of Four Cases of Stevens\u2013Johnson Syndrome among Participants in a Mass Drug Administration Campaign with Sulfadoxine-Pyrimethamine and Primaquine in Haiti, 2020"],"prefix":"10.4269","volume":"108","author":[{"given":"Michelle A.","family":"Chang","sequence":"first","affiliation":[{"name":"Malaria Branch, Division of Parasitic Diseases and Malaria, Center for Global Health, Centers for Disease Control and Prevention, Atlanta, Georgia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernadette","family":"Fouch\u00e9","sequence":"additional","affiliation":[{"name":"CDC Foundation, Atlanta, Georgia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Willy","family":"LaFortune","sequence":"additional","affiliation":[{"name":"Programme National de Contr\u00f4le de la Malaria, Minist\u00e8re de la Sant\u00e9 Publique et de la Population, Port-au-Prince, Haiti;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathleen","family":"Holmes","sequence":"additional","affiliation":[{"name":"Malaria Branch, Division of Parasitic Diseases and Malaria, Center for Global Health, Centers for Disease Control and Prevention, Atlanta, Georgia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonas","family":"Rigodon","sequence":"additional","affiliation":[{"name":"CDC-Haiti, Division of Global Health Protection, Center for Global Health, Centers for Disease Control and Prevention, Port-au-Prince, Haiti;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stanley","family":"Juin","sequence":"additional","affiliation":[{"name":"CDC-Haiti, Division of Global Health Protection, Center for Global Health, Centers for Disease Control and Prevention, Port-au-Prince, Haiti;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samson","family":"Marseille","sequence":"additional","affiliation":[{"name":"Laboratoire National de la Sant\u00e9 Publique, Minist\u00e8re de la Sant\u00e9 Publique et de la Population, Port-au-Prince, Haiti;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Rogier","sequence":"additional","affiliation":[{"name":"Malaria Branch, Division of Parasitic Diseases and Malaria, Center for Global Health, Centers for Disease Control and Prevention, Atlanta, Georgia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Green","sequence":"additional","affiliation":[{"name":"Entomology Branch, Division of Parasitic Diseases and Malaria, Center for Global Health, Centers for Disease Control and Prevention, Atlanta, Georgia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taba","family":"Kheradmand","sequence":"additional","affiliation":[{"name":"Fred H. Allen Immunogenetics Laboratory, New York Blood Center, New York, New York;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuel G.","family":"Moore","sequence":"additional","affiliation":[{"name":"Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David A.","family":"Gaul","sequence":"additional","affiliation":[{"name":"Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia;"},{"name":"School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacques","family":"Boncy","sequence":"additional","affiliation":[{"name":"Laboratoire National de la Sant\u00e9 Publique, Minist\u00e8re de la Sant\u00e9 Publique et de la Population, Port-au-Prince, Haiti;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc-Aurele","family":"Telfort","sequence":"additional","affiliation":[{"name":"Programme National de Contr\u00f4le de la Malaria, Minist\u00e8re de la Sant\u00e9 Publique et de la Population, Port-au-Prince, Haiti;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2795","reference":[{"key":"b1","series-title":"World Malaria Report 2021","year":"2021"},{"key":"b2","author":"Chang","year":"2022"},{"key":"b3","series-title":"WHO Policy Brief on Single-Dose Primaquine as a Gametocytocide in Plasmodium falciparum Malaria","year":"2015"},{"key":"b4","series-title":"National Malaria Case Management Policy, 2014","year":"2014"},{"key":"b5","series-title":"N Engl J Med","first-page":"1600","article-title":"Medication use and the risk of Stevens\u2013Johnson syndrome or toxic epidermal necrolysis","volume":"333","author":"Roujeau","year":"1995"},{"key":"b6","series-title":"Front Med (Lausanne)","first-page":"949520","article-title":"Stevens-Johnson syndrome and toxic epidermal necrolysis: a systematic review of PubMed\/MEDLINE case reports from 1980 to 2020","volume":"9","author":"Wang","year":"2022"},{"key":"b7","series-title":"PLoS Med","first-page":"e1000408","article-title":"Intermittent preventive treatment of malaria provides substantial protection against malaria in children already protected by an insecticide-treated bednet in Burkina Faso: a randomised, double-blind, placebo-controlled trial","volume":"8","author":"Konat\u00e9","year":"2011"},{"key":"b8","series-title":"PLoS Med","first-page":"e1000407","article-title":"Intermittent preventive treatment of malaria provides substantial protection against malaria in children already protected by an insecticide-treated bednet in Mali: a randomised, double-blind, placebo-controlled trial","volume":"8","author":"Dicko","year":"2011"},{"key":"b9","series-title":"PLoS One","first-page":"e0162563","article-title":"Safety of seasonal malaria chemoprevention (SMC) with sulfadoxine-pyrimethamine plus amodiaquine when delivered to children under 10 years of age by district health services in Senegal: results from a stepped-wedge cluster randomized trial","volume":"11","author":"Ndiaye","year":"2016"},{"key":"b10","series-title":"Am J Trop Med Hyg","first-page":"738","article-title":"Severe cutaneous reactions to sulfadoxine-pyriethamine and trimethoprim-sulfamethoxazole in Blantyre District, Malawi","volume":"74","author":"Gimnig","year":"2006"},{"key":"b11","series-title":"Clin Mol Allergy","first-page":"19","article-title":"A case report of toxic epidermal necrolysis (TEN) in a patient with COVID-19 treated with hydroxychloroquine: are these two partners in crime?","volume":"18","author":"Rossi","year":"2020"},{"key":"b12","series-title":"Exp Ther Med","first-page":"257","article-title":"Concomitance or consequence? Stevens-Johnson syndrome in COVID-19: a case report","volume":"23","author":"Manciuc","year":"2022"},{"key":"b13","series-title":"Oxf Med Case Rep","first-page":"omaa042","article-title":"Hydroxychloroquine-induced Stevens\u2013Johnson syndrome in COVID-19: a rare case report","volume":"2020","author":"Davoodi","year":"2020"},{"key":"b14","series-title":"JAMA Intern Med","first-page":"1384","article-title":"US hydroxychloroquine, chloroquine, and azithromycin outpatient prescription trends, October 2019 through March 2020","volume":"180","author":"Shehab","year":"2020"},{"key":"b15","series-title":"NACLA Rep Am","first-page":"69","article-title":"Historical trauma and popular responses to Covid-19","volume":"53","author":"Blanc","year":"2021"},{"key":"b16","series-title":"Am J Trop Med Hyg","first-page":"451","article-title":"Severe cutaneous reactions among American travelers using pyrimethamine-sulfadoxine (Fansidar\u00ae) for malaria prophylaxis","volume":"35","author":"Miller","year":"1986"},{"key":"b17","series-title":"Arch Dermatol","first-page":"1171","article-title":"Genetic susceptibility to toxic epidermal necrolysis","volume":"123","author":"Roujeau","year":"1987"},{"key":"b18","series-title":"Sci Rep","first-page":"5981","article-title":"Trans-ethnic study confirmed independent associations of HLA-A*02:06 and HLA-B*44:03 with cold medicine-related Stevens-Johnson syndrome with severe ocular surface complications","volume":"4","author":"Ueta","year":"2014"},{"key":"b19","series-title":"Sci Rep","first-page":"10589","article-title":"HLA genotypes and cold medicine-induced Stevens\u2013Johnson syndrome\/toxic epidermal necrolysis with severe ocular complications: a systematic review and meta-analysis","volume":"10","author":"Tangamornsuksan","year":"2020"},{"key":"b20","year":"2022"}],"container-title":["The American Journal of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/108\/6\/article-p1140.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/108\/6\/article-p1140.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/108\/6\/article-p1140.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,7]],"date-time":"2023-06-07T13:10:10Z","timestamp":1686143410000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/108\/6\/article-p1140.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,7]]},"references-count":20,"journal-issue":{"issue":"6"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.22-0625","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"value":"0002-9637","type":"print"},{"value":"1476-1645","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,7]]}}}