{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T12:35:36Z","timestamp":1756384536440},"reference-count":21,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"6","license":[{"start":{"date-parts":[[2023,12,6]],"date-time":"2023-12-06T00:00:00Z","timestamp":1701820800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,12,6]]},"abstract":"<jats:title>ABSTRACT.<\/jats:title>\n<jats:p>Here, we report a case of blood culture-confirmed typhoid fever, rhabdomyolysis, and multiple organ damage that arrived in our country from overseas. A 23-year-old male patient presented at our hospital with fever and muscle pain; the condition progressed rapidly. Six days after the onset of symptoms, the patient developed rhabdomyolysis and liver\/kidney damage; levels of creatine kinase (CK; maximum peak: 729,869\u2009U\/L) and myoglobin (&gt;\u00a03,000\u2009ng\/mL) were extremely high, although the extent of renal damage was relatively mild. Blood culture showed <jats:italic>Salmonella typhi<\/jats:italic>. The patient received a combination of meropenem and levofloxacin anti-infective therapy, as well as fluid and nutritional metabolic support. He gradually recovered and was discharged after two negative blood cultures. This case highlights the fact that typhoid-induced rhabdomyolysis is a serious, life-threatening disease and that the levels of CK and myoglobin are useful indicators for evaluating typhoid-induced rhabdomyolysis. Clinicians should remain vigilant regarding travel-related illnesses associated with enteric fever.<\/jats:p>","DOI":"10.4269\/ajtmh.22-0632","type":"journal-article","created":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T20:18:19Z","timestamp":1696882699000},"page":"1220-1222","source":"Crossref","is-referenced-by-count":1,"title":["Case Report: An Imported Case of Typhoid Fever Combined with Rhabdomyolysis and Multiple Organ Lesions in China"],"prefix":"10.4269","volume":"109","author":[{"given":"Qian","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases, Affiliated Hangzhou Xixi Hospital, Zhejiang University School of Medicine, Hangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Affiliated Hangzhou Xixi Hospital, Zhejiang University School of Medicine, Hangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingying","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Affiliated Hangzhou Xixi Hospital, Zhejiang University School of Medicine, Hangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Affiliated Hangzhou Xixi Hospital, Zhejiang University School of Medicine, Hangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yinghui","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Affiliated Hangzhou Xixi Hospital, Zhejiang University School of Medicine, Hangzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2795","reference":[{"key":"b1","series-title":"J Travel Med","first-page":"taab012","article-title":"Typhoid and paratyphoid fever: a clinical 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review on the definition of rhabdomyolysis","volume":"267","author":"Stahl","year":"2020"},{"key":"b16","series-title":"Am J Trop Med Hyg","first-page":"1068","article-title":"Typhoid fever complicated by hemophagocytic lymphohistiocytosis and rhabdomyolysis","volume":"93","author":"Non","year":"2015"},{"key":"b17","series-title":"Nephrol Dial Transplant","first-page":"S435","article-title":"Occurrence of typhoid fever complications and their relation to duration of illness preceding hospitalization: a systematic literature review and meta-analysis","volume":"69","author":"Espinoza","year":"2019"},{"key":"b18","series-title":"Proc Natl Acad Sci USA","first-page":"6338","article-title":"Typhoid toxin provides a window into typhoid fever and the biology of Salmonella typhi","volume":"113","author":"Gal\u00e1n","year":"2016"},{"key":"b19","series-title":"Nature","first-page":"350","article-title":"Structure and function of the Salmonella typhi chimaeric A(2)B(5) typhoid toxin","volume":"499","author":"Song","year":"2013"},{"key":"b20","series-title":"Orphanet J Rare Dis","first-page":"51","article-title":"Rhabdomyolysis: a genetic perspective","volume":"10","author":"Scalco","year":"2015"},{"key":"b21","series-title":"Brain","first-page":"2722","article-title":"MLIP causes recessive myopathy with rhabdomyolysis, myalgia and baseline elevated serum creatine kinase","volume":"144","author":"Neto","year":"2021"}],"container-title":["The American Journal of Tropical Medicine and 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