{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T20:09:56Z","timestamp":1790712596129,"version":"4.1.0"},"reference-count":86,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"2","license":[{"start":{"date-parts":[[2023,8,2]],"date-time":"2023-08-02T00:00:00Z","timestamp":1690934400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,8,2]]},"abstract":"<jats:title>ABSTRACT.<\/jats:title>\n<jats:p><jats:italic>Angiostrongylus cantonensis<\/jats:italic> is the leading cause of neuroangiostrongyliasis worldwide, and east Hawaii Island is a hotspot for the disease in the United States. A combination of glycoproteins with molecular weight of 31\u2009kDa has been used as antigen to evaluate antibody response in human serum samples in Thailand with high specificity and sensitivity. In a previous pilot study, the Thailand-isolated 31-kDa proteins showed efficacy in dot-blot tests using serum samples from 435 human volunteers on Hawaii Island. However, we hypothesized that native antigen isolated from Hawaii <jats:italic>A. cantonensis<\/jats:italic> may exhibit higher specificity than the Thailand-isolated 31-kDa antigen due to potential minor variation in epitopes between isolates. In this study, 31-kDa glycoproteins were isolated by sodium dodecyl-sulfate polyacrylamide gel electrophoresis from adult <jats:italic>A. cantonensis<\/jats:italic> nematodes collected from rats captured on east Hawaii Island. The resultant proteins were purified by electroelution, pooled, bioanalyzed, and quantified. A subset of 148 samples from human participants of the original cohort of 435 was consented for this study, including 12 of the original 15 clinically diagnosed participants. Results of ELISA using the Hawaii-isolated 31-kDa antigen were compared with results of the same serum samples previously tested with both crude Hawaii antigen ELISA and Thailand 31-kDa antigen dot blot. This study shows a seroprevalence in the general population of East Hawaii Island of 25.0%, similar to previous findings of 23.8% seroprevalence in this cohort using crude antigen from Hawaii <jats:italic>A. cantonensis<\/jats:italic> and 26.5% using Thailand 31-kDa antigen.<\/jats:p>","DOI":"10.4269\/ajtmh.22-0643","type":"journal-article","created":{"date-parts":[[2023,6,12]],"date-time":"2023-06-12T14:57:51Z","timestamp":1686581871000},"page":"335-342","source":"Crossref","is-referenced-by-count":4,"title":["Immunodiagnostic Detection of Angiostrongylus cantonensis Exposure on Hawaii Island Using Isogeographic 31-kDa Antigen"],"prefix":"10.4269","volume":"109","author":[{"given":"Susan I.","family":"Jarvi","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Sciences, Daniel K. Inouye College of Pharmacy, University of Hawaii at Hilo, Hilo, Hawaii;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsten","family":"Nakayama","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Daniel K. Inouye College of Pharmacy, University of Hawaii at Hilo, Hilo, Hawaii;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Praphathip","family":"Eamsobhana","sequence":"additional","affiliation":[{"name":"Department of Parasitology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Kaluna","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Daniel K. Inouye College of Pharmacy, University of Hawaii at Hilo, Hilo, Hawaii;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Shepherd","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Daniel K. Inouye College of Pharmacy, University of Hawaii at Hilo, Hilo, Hawaii;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaeko","family":"Tagami","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Daniel K. Inouye College of Pharmacy, University of Hawaii at Hilo, Hilo, Hawaii;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"b1","series-title":"Soc Sci Med","first-page":"199","article-title":"Eosinophilic meningitis beyond the Pacific Basin: the global dispersal of a peridomestic zoonosis caused by Angiostrongylus cantonensis, the nematode lungworm of rats","volume":"34","author":"Kliks","year":"1992"},{"key":"b2","series-title":"Eur J Clin Microbiol Infect Dis","first-page":"389","article-title":"Human Angiostrongylus cantonensis: an update","volume":"31","author":"Wang","year":"2012"},{"key":"b3","series-title":"Hawaii J Med Public Health","first-page":"35","article-title":"Clinical aspects of eosinophilic meningitis and menigoencephalitis caused by Angiostrongylus cantonensis, the rat lungworm","volume":"72","author":"Murphy","year":"2013"},{"key":"b4","series-title":"PLoS One","first-page":"e0189458","article-title":"High prevalence of 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