{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T05:02:00Z","timestamp":1784869320653,"version":"3.55.0"},"reference-count":14,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"5","license":[{"start":{"date-parts":[[2023,5,3]],"date-time":"2023-05-03T00:00:00Z","timestamp":1683072000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,5,3]]},"abstract":"<jats:title>ABSTRACT.<\/jats:title>\n<jats:p>Yaws is a chronic, relapsing disease of skin, bone, and cartilage caused by <jats:italic>Treponema pallidum<\/jats:italic> subsp. <jats:italic>pertenue<\/jats:italic>. Yaws was last reported in Nigeria in 1996, although neighboring countries have recently reported cases. We investigated serological evidence for yaws among children aged 0\u201314 years in Nigeria by measuring antibodies to the treponemal antigens rp17 and TmpA in blood specimens from a 2018 nationally representative HIV survey using a multiplex bead assay. The presence of antibodies to both antigens (\u201cdouble positive\u201d) likely reflects current or recent treponemal infection. Overall, 1.9% (610\/31,549) of children had anti-TmpA antibodies, 1.5% (476\/31,549) had anti-rp17 antibodies, and 0.1% (39\/31,549) were double positive. Among households, 0.5% (84\/18,021) had a double-positive child, with a clustering of double-positive children. Although numbers are low, identification of antibodies to both TmpA and rp17 may warrant investigation, including more granular epidemiologic and clinical data, to assess the potential for continuing yaws transmission in Nigerian children.<\/jats:p>","DOI":"10.4269\/ajtmh.22-0670","type":"journal-article","created":{"date-parts":[[2023,4,10]],"date-time":"2023-04-10T13:37:46Z","timestamp":1681133866000},"page":"977-980","source":"Crossref","is-referenced-by-count":1,"title":["Treponemal Antibody Seroprevalence Using a Multiplex Bead Assay from Samples Collected during the 2018 Nigeria HIV\/AIDS Indicator and Impact Survey: Searching for Yaws in Nigeria"],"prefix":"10.4269","volume":"108","author":[{"given":"Sarah Anne J.","family":"Guagliardo","sequence":"first","affiliation":[{"name":"Division of Parasitic Diseases and Malaria, US Centers for Disease Control and Prevention, Atlanta, Georgia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nishanth","family":"Parameswaran","sequence":"additional","affiliation":[{"name":"Division of Parasitic Diseases and Malaria, US Centers for Disease Control and Prevention, Atlanta, Georgia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ndidi","family":"Agala","sequence":"additional","affiliation":[{"name":"Institute of Human Virology, Abuja, Nigeria;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ado","family":"Abubakar","sequence":"additional","affiliation":[{"name":"Institute of Human Virology, Abuja, Nigeria;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gretchen","family":"Cooley","sequence":"additional","affiliation":[{"name":"Division of Parasitic Diseases and Malaria, US Centers for Disease Control and Prevention, Atlanta, Georgia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tun","family":"Ye","sequence":"additional","affiliation":[{"name":"Center for Global Health, US Centers for Disease Control and Prevention, Atlanta, Georgia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Kamb","sequence":"additional","affiliation":[{"name":"Division of Parasitic Diseases and Malaria, US Centers for Disease Control and Prevention, Atlanta, Georgia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nwando","family":"Mba","sequence":"additional","affiliation":[{"name":"National Reference Laboratory, Nigeria Centre for Disease Control, Abuja, Nigeria;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nwachukwu","family":"William","sequence":"additional","affiliation":[{"name":"National Reference Laboratory, Nigeria Centre for Disease Control, Abuja, Nigeria;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stacie","family":"Greby","sequence":"additional","affiliation":[{"name":"Division of Global HIV and TB, US Centers for Disease Control and Prevention, Abuja, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nnaemeka","family":"Iriemenam","sequence":"additional","affiliation":[{"name":"Division of Global HIV and TB, US Centers for Disease Control and Prevention, Abuja, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Alagi","sequence":"additional","affiliation":[{"name":"Division of Global HIV and TB, US Centers for Disease Control and Prevention, Abuja, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"McPaul","family":"Okoye","sequence":"additional","affiliation":[{"name":"Division of Global HIV and TB, US Centers for Disease Control and Prevention, Abuja, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Martin","sequence":"additional","affiliation":[{"name":"Division of Parasitic Diseases and Malaria, US Centers for Disease Control and Prevention, Atlanta, Georgia;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"b1","year":"2021"},{"key":"b2","series-title":"PLoS Negl Trop Dis","first-page":"e3016","article-title":"Eradication of yaws: historical efforts and achieving WHO\u2019s 2020 target","volume":"8","author":"Asiedu","year":"2014"},{"key":"b3","series-title":"Lancet","first-page":"342","article-title":"Single-dose azithromycin versus benzathine benzylpenicillin for treatment of yaws in children in Papua New Guinea: an open-label, non-inferiority, randomised trial","volume":"379","author":"Mitja","year":"2012"},{"key":"b4","series-title":"Wkly Epidemiol Rec","first-page":"189","article-title":"Eradication of yaws\u2014the Morges strategy","volume":"87","year":"2012"},{"key":"b5","series-title":"Lancet","first-page":"763","article-title":"Yaws","volume":"381","author":"Mitja","year":"2013"},{"key":"b6","series-title":"Bull World Health Organ","first-page":"911","article-title":"Yaws eradication campaign in Nsukka division, eastern Nigeria","volume":"15","author":"Zahra","year":"1956"},{"key":"b7","series-title":"Zentralbl Bakteriol","first-page":"101","article-title":"Yaws and syphilis in the Garkida area of Nigeria","volume":"289","author":"Akogun","year":"1999"},{"key":"b8","series-title":"PLoS Negl Trop Dis","first-page":"e0009180","article-title":"Ulcerative skin lesions among children in Cameroon: it is not always yaws","volume":"15","author":"Ndzomo Ngono","year":"2021"},{"key":"b9","series-title":"Infect Dis Poverty","first-page":"26","article-title":"Factors associated with cutaneous ulcers among children in two yaws-endemic districts in Ghana","volume":"9","author":"Okine","year":"2020"},{"key":"b10","year":"2018"},{"key":"b11","year":"2018"},{"key":"b12","series-title":"Clin Epidemiol","first-page":"119","article-title":"Epidemiology of yaws: an update","volume":"6","author":"Kazadi","year":"2014"},{"key":"b13","series-title":"J Clin Microbiol","first-page":"1321","article-title":"Evaluation of multiplex-based antibody testing for use in large-scale surveillance for yaws: a comparative study","volume":"54","author":"Cooley","year":"2016"},{"key":"b14","series-title":"J Clin Microbiol","first-page":"e02509-20","article-title":"Antibody responses to two recombinant treponemal antigens (rp17 and TmpA) before and after azithromycin treatment for yaws in Ghana and Papua New Guinea","volume":"59","author":"Parameswaran","year":"2021"}],"container-title":["The American Journal of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/108\/5\/article-p977.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/108\/5\/article-p977.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/108\/5\/article-p977.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,3]],"date-time":"2023-05-03T19:55:29Z","timestamp":1683143729000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/108\/5\/article-p977.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,3]]},"references-count":14,"journal-issue":{"issue":"5"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.22-0670","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"value":"0002-9637","type":"print"},{"value":"1476-1645","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,3]]}}}