{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T07:20:46Z","timestamp":1790925646738,"version":"4.1.0"},"reference-count":14,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"4","license":[{"start":{"date-parts":[[2023,4,5]],"date-time":"2023-04-05T00:00:00Z","timestamp":1680652800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,4,5]]},"abstract":"<jats:title>ABSTRACT.<\/jats:title>\n                  <jats:p>In the pivotal phase 3 efficacy trial (NCT02747927) of the TAK-003 dengue vaccine, 5 of 13,380 TAK-003 recipients and 13 of 6,687 placebo recipients experienced two episodes of symptomatic dengue between the first dose and the end of the study, \u223c57 months later (patients received the second dose 3 months after the first dose). Two of these participants experienced repeat infection with the same serotype (i.e., homotypic reinfection). In comparison with placebo, the relative risk of a subsequent episode of symptomatic dengue was 0.19 (95% CI, 0.07\u20130.54) in TAK-003 recipients. Based on the small number of subsequent episodes, these data suggest a potential incremental effect of TAK-003 beyond prevention of the first episode of symptomatic dengue after vaccination.<\/jats:p>","DOI":"10.4269\/ajtmh.22-0673","type":"journal-article","created":{"date-parts":[[2023,3,6]],"date-time":"2023-03-06T08:48:03Z","timestamp":1678092483000},"page":"722-726","source":"Crossref","is-referenced-by-count":26,"title":["Effect of the Tetravalent Dengue Vaccine TAK-003 on Sequential Episodes of Symptomatic Dengue"],"prefix":"10.4269","volume":"108","author":[{"given":"Xavier","family":"S\u00e1ez-Llorens","sequence":"first","affiliation":[{"name":"Hospital del Ni\u00f1o Dr. Jos\u00e9 Ren\u00e1n Esquivel, Sistema Nacional de Investigaci\u00f3n at SENACYT, Centro de Vacunaci\u00f3n Internacional (Cevaxin), Panama City, Panama;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shibadas","family":"Biswal","sequence":"additional","affiliation":[{"name":"Takeda Vaccines, Inc., Cambridge, Massachusetts;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charissa","family":"Borja-Tabora","sequence":"additional","affiliation":[{"name":"Research Institute For Tropical Medicine, Muntinlupa, Philippines;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"LakKumar","family":"Fernando","sequence":"additional","affiliation":[{"name":"Centre for Clinical Management of Dengue & Dengue Haemorrhagic Fever, Negombo General Hospital, Negombo, Sri Lanka;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengya","family":"Liu","sequence":"additional","affiliation":[{"name":"Takeda Vaccines, Inc., Cambridge, Massachusetts;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derek","family":"Wallace","sequence":"additional","affiliation":[{"name":"Takeda Vaccines, Inc., Cambridge, Massachusetts;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Folschweiller","sequence":"additional","affiliation":[{"name":"Takeda Pharmaceuticals International AG, Zurich, Switzerland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Humberto","family":"Reynales","sequence":"additional","affiliation":[{"name":"Centro de Atenci\u00f3n e Investigaci\u00f3n M\u00e9dica, CAIMED, Bogot\u00e1, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inge","family":"LeFevre","sequence":"additional","affiliation":[{"name":"Takeda Pharmaceuticals International AG, Zurich, Switzerland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"_","family":"_","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"b1","series-title":"PLoS Negl Trop Dis","first-page":"e1760","article-title":"Refining the global spatial limits of dengue virus 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1994\u20132010","volume":"15","author":"Bhoomiboonchoo","year":"2015"},{"key":"b6","series-title":"PLoS One","first-page":"e0154760","article-title":"Meta-analysis of dengue severity during infection by different dengue virus serotypes in primary and secondary infections","volume":"11","author":"Soo","year":"2016"},{"key":"b7","series-title":"Lancet","first-page":"1423","article-title":"Efficacy of a tetravalent dengue vaccine in healthy children aged 4-16 years: a randomised, placebo-controlled, phase 3 trial","volume":"395","author":"Biswal","year":"2020"},{"key":"b8","series-title":"N Engl J Med","first-page":"2009","article-title":"Efficacy of a tetravalent dengue vaccine in healthy children and adolescents","volume":"381","author":"Biswal","year":"2019"},{"key":"b9","series-title":"J Infect Dis","first-page":"1521","article-title":"Efficacy of a dengue vaccine candidate (TAK-003) in healthy children and adolescents 2 years after vaccination","volume":"225","author":"L\u00f3pez-Medina","year":"2022"},{"key":"b10","series-title":"Clin Infect Dis","first-page":"107","article-title":"Three-year efficacy and safety of Takeda\u2019s dengue vaccine candidate (TAK-003)","volume":"75","author":"Rivera","year":"2022"},{"key":"b11","series-title":"Dengue Haemorrhagic Fever: Diagnosis, Treatment, Prevention and Control","year":"1997"},{"key":"b12","series-title":"Trends Microbiol","first-page":"138","article-title":"Global spread of dengue virus types: mapping the 70 year history","volume":"22","author":"Messina","year":"2014"},{"key":"b13","series-title":"J Infect Dis","first-page":"979","article-title":"Dengue viruses and lifelong immunity: reevaluating the conventional wisdom","volume":"214","author":"Forshey","year":"2016"},{"key":"b14","series-title":"Nature","first-page":"504","article-title":"The global distribution and burden of dengue","volume":"496","author":"Bhatt","year":"2013"}],"container-title":["The 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Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/108\/4\/article-p722.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/108\/4\/article-p722.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/108\/4\/article-p722.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,5]],"date-time":"2023-04-05T10:53:36Z","timestamp":1680692016000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/108\/4\/article-p722.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,5]]},"references-count":14,"journal-issue":{"issue":"4"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.22-0673","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"value":"0002-9637","type":"print"},{"value":"1476-1645","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,5]]}}}