{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T20:40:35Z","timestamp":1790973635669,"version":"4.1.0"},"reference-count":23,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"3","license":[{"start":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T00:00:00Z","timestamp":1693958400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,9,6]]},"abstract":"<jats:title>ABSTRACT.<\/jats:title>\n<jats:p>The co-occurrence of COVID-19 with endemic diseases is a public health concern that may affect patient prognosis and outcomes. The objective of this study was to describe the clinical characteristics of patients with dengue virus (DENV) and SARS-CoV-2 co-infections and compare their outcomes against those of COVID-19 patients without dengue. A cross-sectional study was conducted in patients with SARS-CoV-2 infection who attended a single center in Cali, Colombia, from March 2020 to March 2021. All patients who were tested by both real-time polymerase chain reaction for SARS-CoV-2 and IgM\/NS1 for DENV were included. Dengue was diagnosed as having either an IgM- or an NS1- positive test. A total of 90 patients were included (72 with COVID-19 only and 18 with co-infection). Patients with co-infection had more dyspnea (61.1% versus 22.2%; <jats:italic>P<\/jats:italic> = 0.003) as well as higher oxygen desaturation (53.3% versus 13.4%; <jats:italic>P<\/jats:italic> = 0.002) and neutrophil-to-lymphocyte ratio (5.59 versus 3.84; <jats:italic>P<\/jats:italic> = 0.038) than patients with COVID-19 alone. The proportion of patients classified with moderate to severe COVID-19 was higher in the co-infection group (88.3% versus 47.8%; <jats:italic>P<\/jats:italic> = 0.002). Also, co-infection was associated with an increased need for mechanical ventilation (<jats:italic>P<\/jats:italic> = 0.06), intensive care unit (ICU) initial management (<jats:italic>P<\/jats:italic> = 0.02), and ICU admission during hospitalization (<jats:italic>P<\/jats:italic> = 0.04) compared with COVID-19 only. The ICU mortality rate was 66.6% in patients with co-infection versus 29.4% in patients infected with only SARS-CoV-2 (<jats:italic>P<\/jats:italic> &lt; 0.05). The possibility of DENV and SARS-CoV2 co-infection occurred in the convergence of both epidemic waves. Co-infection was associated with worse clinical outcomes and higher mortality in ICU-admitted patients than in patients with the COVID-19 only.<\/jats:p>","DOI":"10.4269\/ajtmh.22-0717","type":"journal-article","created":{"date-parts":[[2023,8,14]],"date-time":"2023-08-14T14:14:09Z","timestamp":1692022449000},"page":"536-541","source":"Crossref","is-referenced-by-count":9,"title":["Co-Infection between Dengue Virus and SARS-CoV-2 in Cali, Colombia"],"prefix":"10.4269","volume":"109","author":[{"given":"Olga Lucia","family":"Agudelo-Rojas","sequence":"first","affiliation":[{"name":"Centro de Investigaciones Cl\u00ednicas, Fundaci\u00f3n Valle del Lili, Cali, Colombia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David Esteban","family":"Rebell\u00f3n-S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Centro de Investigaciones Cl\u00ednicas, Fundaci\u00f3n Valle del Lili, Cali, Colombia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julio","family":"Llanos Torres","sequence":"additional","affiliation":[{"name":"Centro de Investigaciones Cl\u00ednicas, Fundaci\u00f3n Valle del Lili, Cali, Colombia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel Lucia","family":"Zapata-V\u00e1squez","sequence":"additional","affiliation":[{"name":"Centro de Investigaciones Cl\u00ednicas, Fundaci\u00f3n Valle del Lili, Cali, Colombia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarita","family":"Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Centro de Investigaciones Cl\u00ednicas, Fundaci\u00f3n Valle del Lili, Cali, Colombia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebasti\u00e1n","family":"Robles-Castillo","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias de la Salud, Universidad Icesi, Cali, Colombia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Tejada Vega","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias de la Salud, Universidad Icesi, Cali, Colombia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis Gabriel","family":"Parra-Lara","sequence":"additional","affiliation":[{"name":"Centro de Investigaciones Cl\u00ednicas, Fundaci\u00f3n Valle del Lili, Cali, Colombia;"},{"name":"Facultad de Ciencias de la Salud, Universidad Icesi, Cali, Colombia;"},{"name":"Departamento de Salud P\u00fablica y Medicina Comunitaria, Facultad de Ciencias de la Salud, Cali, Colombia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Rosso","sequence":"additional","affiliation":[{"name":"Centro de Investigaciones Cl\u00ednicas, Fundaci\u00f3n Valle del Lili, Cali, Colombia;"},{"name":"Servicio de Enfermedades Infecciosas, Departamento de Medicina Interna, Fundaci\u00f3n Valle del Lili, Cali, Colombia;"},{"name":"Departamento de Ciencias Cl\u00ednicas, Universidad Icesi, Cali, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"b1","series-title":"J Med Virol","first-page":"161","article-title":"Coinfection, coepidemics of COVID-19, and dengue in dengue-endemic countries: a serious health concern","volume":"93","author":"Miah","year":"2021"},{"key":"b2","year":"2021"},{"key":"b3","series-title":"Trop Doct","first-page":"106","article-title":"COVID-19 and\/with dengue infection: a curse in an overburdened healthcare system","volume":"51","author":"Panda","year":"2021"},{"key":"b4","series-title":"J Infect","first-page":"266","article-title":"Co-infections in people with COVID-19: a systematic review and meta-analysis","volume":"81","author":"Lansbury","year":"2020"},{"key":"b5","series-title":"Acta Trop","first-page":"105782","article-title":"Clinical and biochemical parameters of COVID-19 patients with prior or active dengue fever","volume":"214","author":"Teot\u00f4nio","year":"2021"},{"key":"b6","series-title":"Lancet Infect Dis","first-page":"536","article-title":"Covert COVID-19 and false-positive dengue serology in Singapore","volume":"20","author":"Yan","year":"2020"},{"key":"b7","series-title":"Int J Infect Dis","first-page":"152","article-title":"Serological cross-reaction and coinfection of dengue and COVID-19 in Asia: experience from Indonesia","volume":"102","author":"Masyeni","year":"2021"},{"key":"b8","series-title":"Am J Trop Med Hyg","first-page":"745","article-title":"Differentiating dengue from COVID-19: comparison of cases in Colombia","volume":"105","author":"Rosso","year":"2021"},{"key":"b9","year":"2023"},{"key":"b10","series-title":"Lancet Infect Dis","first-page":"533","article-title":"An interactive web-based dashboard to track COVID-19 in real time","volume":"20","author":"Dong","year":"2020"},{"key":"b11","series-title":"COVID-19 Clinical Management: Living Guidance, 25 January 2021","year":"2021"},{"key":"b12","series-title":"Braz J Infect Dis","first-page":"583","article-title":"Concerns about COVID-19 and arboviral (chikungunya, dengue, Zika) concurrent outbreaks","volume":"24","author":"do Ros\u00e1rio","year":"2020"},{"key":"b13","series-title":"New Microbes New Infect","first-page":"101041","article-title":"COVID-19 and dengue coinfection in Latin America: a systematic review","volume":"49\u201350","author":"Le\u00f3n-Figueroa","year":"2022"},{"key":"b14","series-title":"Emerg Infect Dis","first-page":"348","article-title":"Characteristics of patients co-infected with severe acute respiratory syndrome Coronavirus 2 and dengue virus, Buenos Aires, Argentina, March\u2013June 2020","volume":"27","author":"Carosella","year":"2021"},{"key":"b15","series-title":"Travel Med Infect Dis","first-page":"102132","article-title":"Characteristics of patients coinfected with severe acute respiratory syndrome Coronavirus 2 and dengue virus, Lambayeque, Peru, 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Infect","first-page":"e6","article-title":"Neutrophil-to-lymphocyte ratio as an independent risk factor for mortality in hospitalized patients with COVID-19","volume":"81","author":"Liu","year":"2020"},{"key":"b21","series-title":"J Infect","first-page":"e16","article-title":"Emergence of co-infection of COVID-19 and dengue: a serious public health threat","volume":"81","author":"Saddique","year":"2020"},{"key":"b22","series-title":"Front Immunol","first-page":"707287","article-title":"Identification of COVID-19 and dengue host factor interaction networks based on integrative bioinformatics analyses","volume":"12","author":"Zheng","year":"2021"},{"key":"b23","series-title":"Cad Saude Publica","first-page":"e00225618","article-title":"Rapid immunochromatographic tests for the diagnosis of dengue: a systematic review and meta-analysis","volume":"36","author":"Mata","year":"2020"}],"container-title":["The American Journal of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/109\/3\/article-p536.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/109\/3\/article-p536.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/109\/3\/article-p536.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T13:53:37Z","timestamp":1694008417000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/109\/3\/article-p536.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,6]]},"references-count":23,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.22-0717","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"value":"0002-9637","type":"print"},{"value":"1476-1645","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,6]]}}}