{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T07:03:24Z","timestamp":1792134204687,"version":"4.4.0"},"reference-count":29,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,12,6]]},"abstract":"<jats:title>ABSTRACT.<\/jats:title>\n<jats:p>Sporotrichosis is the most frequent subcutaneous mycosis in Latin America. <jats:italic>Sporothrix brasiliensis<\/jats:italic> is the most virulent species, responsible for the majority of human and animal cases in Brazil. Osteomyelitis was described as a potential comorbidity of <jats:italic>S. brasiliensis<\/jats:italic> infection; however, surgical amputation resulting from an extracutaneous form is a rare outcome. In such cases, immunodeficiency and alcoholism must be investigated. We present two unusual cases of surgical amputation as a severe morbidity resulting from osteomyelitis by <jats:italic>S. brasiliensis<\/jats:italic> in immunocompetent nonalcoholic patients.<\/jats:p>","DOI":"10.4269\/ajtmh.22-0755","type":"journal-article","created":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T15:06:16Z","timestamp":1698678376000},"page":"1351-1355","source":"Crossref","is-referenced-by-count":6,"title":["Case Report: Osteomyelitis Due to Sporothrix brasiliensis in Two Immunocompetent Patients Requiring Surgical Amputation"],"prefix":"10.4269","volume":"109","author":[{"given":"Alexsander Moreira","family":"Siqueira","sequence":"first","affiliation":[{"name":"Center for Microorganisms Investigation, Biomedical Institute, Federal Fluminense University, Niter\u00f3i, Brazil;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendel Marcel","family":"D\u2019Angioli","sequence":"additional","affiliation":[{"name":"Center for Microorganisms Investigation, Biomedical Institute, Federal Fluminense University, Niter\u00f3i, Brazil;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e1rbara","family":"Lapera","sequence":"additional","affiliation":[{"name":"Center for Microorganisms Investigation, Biomedical Institute, Federal Fluminense University, Niter\u00f3i, Brazil;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabella Gomes Carvalho de","family":"Souza","sequence":"additional","affiliation":[{"name":"Center for Microorganisms Investigation, Biomedical Institute, Federal Fluminense University, Niter\u00f3i, Brazil;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noel","family":"L\u00f6wenthal","sequence":"additional","affiliation":[{"name":"Center for Microorganisms Investigation, Biomedical Institute, Federal Fluminense University, Niter\u00f3i, Brazil;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00falia","family":"Rossit","sequence":"additional","affiliation":[{"name":"Center for Microorganisms Investigation, Biomedical Institute, Federal Fluminense University, Niter\u00f3i, Brazil;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone de Abreu Neves","family":"Salles","sequence":"additional","affiliation":[{"name":"Dermatology Service, Ant\u00f4nio Pedro University Hospital, Federal Fluminense University, Niter\u00f3i, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo Luiz Dantas","family":"Machado","sequence":"additional","affiliation":[{"name":"Center for Microorganisms Investigation, Biomedical Institute, Federal Fluminense University, Niter\u00f3i, Brazil;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth Martins da Silva da","family":"Rocha","sequence":"additional","affiliation":[{"name":"Center for Microorganisms Investigation, Biomedical Institute, Federal Fluminense University, Niter\u00f3i, Brazil;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9a Regina de Souza","family":"Baptista","sequence":"additional","affiliation":[{"name":"Center for Microorganisms Investigation, Biomedical Institute, Federal Fluminense University, Niter\u00f3i, Brazil;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"b1","series-title":"Virulence","first-page":"112","article-title":"Increase in virulence of Sporothrix brasiliensis over five years in a patient with chronic disseminated sporotrichosis","volume":"6","author":"Freitas","year":"2015"},{"key":"b2","series-title":"An Bras Dermatol","first-page":"376","article-title":"Systemic sporotrichosis in an alcoholic patient","volume":"95","author":"Barros","year":"2020"},{"key":"b3","series-title":"Indian J Dermatol","first-page":"236","article-title":"Atypical cutaneous sporotrichosis in an 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