{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T23:03:24Z","timestamp":1777590204757,"version":"3.51.4"},"reference-count":36,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"1","license":[{"start":{"date-parts":[[2023,7,5]],"date-time":"2023-07-05T00:00:00Z","timestamp":1688515200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,7,5]]},"abstract":"<jats:title>ABSTRACT.<\/jats:title>\n<jats:p>The radiation-attenuated <jats:italic>Plasmodium falciparum<\/jats:italic> sporozoites (PfSPZ) Vaccine has demonstrated safety and immunogenicity in 5-month-old to 50-year-old Africans in multiple trials. Except for one, each trial has restricted enrollment to either infants and children or adults &lt; 50 years old. This trial was conducted in Equatorial Guinea and assessed the safety, tolerability, and immunogenicity of three direct venous inoculations of 1.8 \u00d7 10<jats:sup>6<\/jats:sup> or 2.7 \u00d7 10<jats:sup>6<\/jats:sup> PfSPZ, of PfSPZ Vaccine, or normal saline administered at 8-week intervals in a randomized, double-blind, placebo-controlled trial stratified by age (6\u201311 months and 1\u20135, 6\u201310, 11\u201317, 18\u201335, and 36\u201361 years). All doses were successfully administered. In all, 192\/207 injections (93%) in those aged 6\u201361 years were rated as causing no or mild pain. There were no significant differences in solicited adverse events (AEs) between vaccinees and controls in any age group (<jats:italic>P<\/jats:italic> \u2265 0.17). There were no significant differences between vaccinees and controls with respect to the rates or severity of unsolicited AEs or laboratory abnormalities. Development of antibodies to <jats:italic>P. falciparum<\/jats:italic> circumsporozoite protein occurred in 67\/69 vaccinees (97%) and 0\/15 controls. Median antibody levels were highest in infants and 1\u20135-year-olds and declined progressively with age. Antibody responses in children were greater than in adults protected against controlled human malaria infection. Robust immunogenicity, combined with a benign AE profile, indicates children are an ideal target for immunization with PfSPZ Vaccine.<\/jats:p>","DOI":"10.4269\/ajtmh.22-0773","type":"journal-article","created":{"date-parts":[[2023,5,9]],"date-time":"2023-05-09T21:33:18Z","timestamp":1683667998000},"page":"138-146","source":"Crossref","is-referenced-by-count":8,"title":["Safety and Immunogenicity of Radiation-Attenuated PfSPZ Vaccine in Equatoguinean Infants, Children, and Adults"],"prefix":"10.4269","volume":"109","author":[{"given":"Said A.","family":"Jongo","sequence":"first","affiliation":[{"name":"Ifakara Health Institute, Bagamoyo Research and Training Centre, Bagamoyo, Tanzania;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vicente","family":"Urbano Nsue Ndong Nchama","sequence":"additional","affiliation":[{"name":"Ministry of Health and Social Welfare, Government of Equatorial Guinea, Malabo, Equatorial Guinea;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. 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