{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T13:41:58Z","timestamp":1779889318971,"version":"3.53.1"},"reference-count":19,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,12,6]]},"abstract":"<jats:title>ABSTRACT.<\/jats:title>\n<jats:p>Oral ulcers are often neglected in patients with AIDS. However, giant oral ulcers are uncommon and are usually suspected to be malignant lesions. Our study presents a case of giant ulcers in an AIDS patient that were initially suspected to be oral cancer. To assist with diagnosis, conventional microbiological tests, metagenomic next-generation sequencing, and a pathological examination were conducted on oral lesion biopsy specimens. The case was finally confirmed via hematoxylin-eosin staining and immunohistochemical staining to be a cytomegalovirus infection.<\/jats:p>","DOI":"10.4269\/ajtmh.22-0775","type":"journal-article","created":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T16:29:14Z","timestamp":1697473754000},"page":"1274-1276","source":"Crossref","is-referenced-by-count":2,"title":["Case Report: Giant Oral Ulcers Attributed to Cytomegalovirus Infection in a Patient with AIDS"],"prefix":"10.4269","volume":"109","author":[{"given":"Jinli","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases, Zhongnan Hospital of Wuhan University, Wuhan, China;"},{"name":"Wuhan Research Center for Infectious Diseases and Cancer, Chinese Academy of Medical Sciences, Wuhan, China;"},{"name":"Hubei Engineering Center for Infectious Disease Prevention, Control, and Treatment, Wuhan, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuting","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Zhongnan Hospital of Wuhan University, Wuhan, China;"},{"name":"Wuhan Research Center for Infectious Diseases and Cancer, Chinese Academy of Medical Sciences, Wuhan, China;"},{"name":"Hubei Engineering Center for Infectious Disease Prevention, Control, and Treatment, Wuhan, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shihui","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Zhongnan Hospital of Wuhan University, Wuhan, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Zhongnan Hospital of Wuhan University, Wuhan, China;"},{"name":"Wuhan Research Center for Infectious Diseases and Cancer, Chinese Academy of Medical Sciences, Wuhan, China;"},{"name":"Hubei Engineering Center for Infectious Disease Prevention, Control, and Treatment, Wuhan, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi","family":"Zou","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Zhongnan Hospital of Wuhan University, Wuhan, China;"},{"name":"Wuhan Research Center for Infectious Diseases and Cancer, Chinese Academy of Medical Sciences, Wuhan, China;"},{"name":"Hubei Engineering Center for Infectious Disease Prevention, Control, and Treatment, Wuhan, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingqi","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Zhongnan Hospital of Wuhan University, Wuhan, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Pathology, Wuhan University Taikang Medical School (School of Basic Medical Sciences), Wuhan, China;"},{"name":"Pathology Department, Zhongnan Hospital of Wuhan University, Wuhan, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Zhongnan Hospital of Wuhan University, Wuhan, China;"},{"name":"Wuhan Research Center for Infectious Diseases and Cancer, Chinese Academy of Medical Sciences, Wuhan, China;"},{"name":"Hubei Engineering Center for Infectious Disease Prevention, Control, and Treatment, Wuhan, China;"},{"name":"Department of Nosocomial Infection Management, Zhongnan Hospital of Wuhan University, Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"b1","series-title":"J Dent Indones","first-page":"50","article-title":"Oral ulcers induced by cytomegalovirus infection: report on two cases","volume":"24","author":"Ribas","year":"2017"},{"key":"b2","series-title":"Pan Afr Med J","first-page":"180","article-title":"Prevalence of HIV related oral lesions in people living with HIV and on combined antiretroviral therapy: a Nigerian experience","volume":"31","author":"Mary","year":"2018"},{"key":"b3","series-title":"Dent Update","first-page":"513","article-title":"Oral medicine: 1. 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Clinical findings, diagnosis, and treatment","volume":"108","author":"Jacobson","year":"1988"},{"key":"b6","series-title":"PLoS One","first-page":"e75915","article-title":"Spectrums of opportunistic infections and malignancies in HIV-infected patients in tertiary care hospital, China","volume":"8","author":"Xiao","year":"2013"},{"key":"b7","series-title":"Hum Immunol","first-page":"381","article-title":"Pathogenesis of human cytomegalovirus infection and cellular targets","volume":"65","author":"Gerna","year":"2004"},{"key":"b8","series-title":"Rev Infect Dis","first-page":"205","article-title":"Latent infection and the elusive cytomegalovirus","volume":"5","author":"Jordan","year":"1983"},{"key":"b9","series-title":"Am J Ophthalmol","first-page":"48","article-title":"Characteristics of patients with cytomegalovirus retinitis in the era of highly active antiretroviral therapy","volume":"133","author":"Jabs","year":"2002"},{"key":"b10","year":"2021"},{"key":"b11","series-title":"Case Rep Dent","first-page":"8843816","article-title":"A case of cytomegalovirus-induced oral ulcer in an older adult patient with nephrotic syndrome due to membranous nephropathy","volume":"2020","author":"Sato","year":"2020"},{"key":"b12","series-title":"J Clin Periodontol","first-page":"282","article-title":"Cytomegalovirus infection presenting as acute periodontal infection in a patient infected with the human immunodeficiency virus","volume":"20","author":"Dodd","year":"1993"},{"key":"b13","series-title":"Oral Dis","first-page":"S180","article-title":"Oral ulcerations in HIV infection","volume":"3","author":"Reichart","year":"1997"},{"key":"b14","series-title":"Int J STD AIDS","first-page":"410","article-title":"Unusual presentation of secondary syphilis: membranoproliferative glomerulonephritis and muco-cutaneous lesions","volume":"29","author":"Tognetti","year":"2017"},{"key":"b15","series-title":"Ann Palliat Med","first-page":"2710","article-title":"Cytomegalovirus (CMV) infection in HIV\/AIDS patients and diagnostic values of CMV-DNA detection across different sample types","volume":"9","author":"Zhao","year":"2020"},{"key":"b16","series-title":"Hum Pathol","first-page":"103","article-title":"Localization of cytomegalovirus antigens in liver allografts over time","volume":"24","author":"Theise","year":"1993"},{"key":"b17","series-title":"J Oral Pathol Med","first-page":"268","article-title":"Oral infections due to cytomegalovirus in immunocompromised patients","volume":"22","author":"Schubert","year":"1993"},{"key":"b18","series-title":"J Am Dent Assoc","first-page":"99","article-title":"Oral CMV lesions and the HIV infected: early recognition can help prevent morbidity","volume":"124","author":"Heinic","year":"1993"},{"key":"b19","series-title":"J Oral Pathol Med","first-page":"71","article-title":"Cytomegalovirus associated oral ulcerations in HIV-infected patients","volume":"19","author":"Langford","year":"1990"}],"container-title":["The American Journal of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/109\/6\/article-p1274.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/109\/6\/article-p1274.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/109\/6\/article-p1274.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,6]],"date-time":"2023-12-06T15:44:38Z","timestamp":1701877478000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/109\/6\/article-p1274.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,6]]},"references-count":19,"journal-issue":{"issue":"6"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.22-0775","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"value":"0002-9637","type":"print"},{"value":"1476-1645","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,6]]}}}