{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T07:44:19Z","timestamp":1772005459572,"version":"3.50.1"},"reference-count":15,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,6,7]]},"abstract":"<jats:title>ABSTRACT.<\/jats:title>\n<jats:p>Patients with subarachnoid neurocysticercosis (NCC) are usually older than those with parenchymal disease. Whether this difference reflects a prolonged presymptomatic period or a delay in diagnosis is not clear. From 408 eligible patients, we retrospectively compared the age at symptom onset in 140 patients diagnosed with parenchymal (pure viable or pure calcified) and subarachnoid NCC who had a confirmatory image available not more than 2 years after the beginning of symptoms. Patients with mixed (parenchymal and subarachnoid) NCC or those with parenchymal cysts at different stages (viable and\/or degenerating and\/or calcified) were not included. After controlling by sex and residence in rural endemic regions, the mean age at symptom onset in patients with subarachnoid disease was 13.69 years older than those with viable parenchymal disease. A long incubation period is a major contributing factor to older age at presentation in subarachnoid NCC, independent of delayed diagnosis or access to care.<\/jats:p>","DOI":"10.4269\/ajtmh.22-0791","type":"journal-article","created":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T19:30:01Z","timestamp":1682969401000},"page":"1188-1191","source":"Crossref","is-referenced-by-count":7,"title":["Older Age in Subarachnoid Neurocysticercosis Reflects a Long Prepatent Period"],"prefix":"10.4269","volume":"108","author":[{"given":"Fernando","family":"Nateros","sequence":"first","affiliation":[{"name":"Facultad de Medicina Alberto Hurtado, Universidad Peruana Cayetano Heredia, Lima, Peru;"},{"name":"Centro B\u00e1sico de Investigaci\u00f3n en Ex\u00e1menes Auxiliares en Parasitosis del Sistema Nervioso Central, Instituto Nacional de Ciencias Neurol\u00f3gicas, Lima, Peru;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edith","family":"Saenz","sequence":"additional","affiliation":[{"name":"Centro B\u00e1sico de Investigaci\u00f3n en Ex\u00e1menes Auxiliares en Parasitosis del Sistema Nervioso Central, Instituto Nacional de Ciencias Neurol\u00f3gicas, Lima, Peru;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Herbert","family":"Saavedra","sequence":"additional","affiliation":[{"name":"Centro B\u00e1sico de Investigaci\u00f3n en Ex\u00e1menes Auxiliares en Parasitosis del Sistema Nervioso Central, Instituto Nacional de Ciencias Neurol\u00f3gicas, Lima, Peru;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isidro","family":"Gonzales","sequence":"additional","affiliation":[{"name":"Centro B\u00e1sico de Investigaci\u00f3n en Ex\u00e1menes Auxiliares en Parasitosis del Sistema Nervioso Central, Instituto Nacional de Ciencias Neurol\u00f3gicas, Lima, Peru;"},{"name":"Unidad de Investigaci\u00f3n, Instituto Nacional de Ciencias Neurol\u00f3gicas, Lima, Peru;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. Javier","family":"Pretell","sequence":"additional","affiliation":[{"name":"Hospital Nacional Alberto Sabogal, Callao, Peru;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erika","family":"Perez","sequence":"additional","affiliation":[{"name":"Centro B\u00e1sico de Investigaci\u00f3n en Ex\u00e1menes Auxiliares en Parasitosis del Sistema Nervioso Central, Instituto Nacional de Ciencias Neurol\u00f3gicas, Lima, Peru;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yesenia","family":"Castillo","sequence":"additional","affiliation":[{"name":"Centro de Salud Global, Universidad Peruana Cayetano Heredia, Lima, Peru"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier A.","family":"Bustos","sequence":"additional","affiliation":[{"name":"Centro B\u00e1sico de Investigaci\u00f3n en Ex\u00e1menes Auxiliares en Parasitosis del Sistema Nervioso Central, Instituto Nacional de Ciencias Neurol\u00f3gicas, Lima, Peru;"},{"name":"Centro de Salud Global, Universidad Peruana Cayetano Heredia, Lima, Peru"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hector H.","family":"Garcia","sequence":"additional","affiliation":[{"name":"Centro B\u00e1sico de Investigaci\u00f3n en Ex\u00e1menes Auxiliares en Parasitosis del Sistema Nervioso Central, Instituto Nacional de Ciencias Neurol\u00f3gicas, Lima, Peru;"},{"name":"Centro de Salud Global, Universidad Peruana Cayetano Heredia, Lima, Peru"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"_","family":"_","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2795","reference":[{"key":"b1","series-title":"J Neurol Sci","first-page":"117527","article-title":"Neurocysticercosis. A frequent cause of seizures, epilepsy, and other neurological morbidity in most of the world","volume":"427","author":"Bustos","year":"2021"},{"key":"b2","series-title":"Expert Rev Anti Infect Ther","first-page":"123","article-title":"Subarachnoid basal neurocysticercosis: a focus on the most severe form of the disease","volume":"9","author":"Fleury","year":"2011"},{"key":"b3","series-title":"Am J Trop Med Hyg","first-page":"176","article-title":"Mortality in parenchymal and subarachnoid neurocysticercosis","volume":"105","author":"Abanto","year":"2021"},{"key":"b4","series-title":"PLoS Negl Trop Dis","first-page":"e0005646","article-title":"Extraparenchymal neurocysticercosis: demographic, clinicoradiological, and inflammatory features","volume":"11","author":"Marcin-Sierra","year":"2017"},{"key":"b5","series-title":"J Neurol","first-page":"830","article-title":"Symptomatic human neurocysticercosis: age, sex and exposure factors relating with disease heterogeneity","volume":"251","author":"Fleury","year":"2004"},{"key":"b6","series-title":"J Neurol","first-page":"15","article-title":"Active neurocysticercosis, parenchymal and extraparenchymal: a study of 38 patients","volume":"241","author":"Monteiro","year":"1993"},{"key":"b7","series-title":"PLoS Negl Trop Dis","first-page":"e0005115","article-title":"Clinical symptoms, imaging features and cyst distribution in the cerebrospinal fluid compartments in patients with extraparenchymal neurocysticercosis","volume":"10","author":"Bazan","year":"2016"},{"key":"b8","series-title":"Curr Opin Infect Dis","first-page":"339","article-title":"Subarachnoid neurocysticercosis: emerging concepts and treatment","volume":"33","author":"Nash","year":"2020"},{"key":"b9","series-title":"J Infect Dis","first-page":"1345","article-title":"Detection of Taenia solium antigens and anti\u2013T. solium antibodies in paired serum and cerebrospinal fluid samples from patients with intraparenchymal or extraparenchymal neurocysticercosis","volume":"199","author":"Rodriguez","year":"2009"},{"key":"b10","series-title":"Clin Infect Dis","first-page":"282","article-title":"Antibody banding patterns of the enzyme-linked immunoelectrotransfer blot and brain imaging findings in patients with neurocysticercosis","volume":"66","author":"Arroyo","year":"2018"},{"key":"b11","series-title":"Medicine (Baltimore)","first-page":"81","article-title":"Neurocysticercosis in Houston, Texas: an update","volume":"90","author":"Serpa","year":"2011"},{"key":"b12","author":"Dixon","year":"1961"},{"key":"b13","series-title":"J Travel Med","first-page":"112","article-title":"Neurocysticercosis among international travelers to disease\u2010endemic areas","volume":"19","author":"Del Brutto","year":"2012"},{"key":"b14","series-title":"Trans R Soc Trop Med Hyg","first-page":"1218","article-title":"Natural history of extraparenchymal neurocysticercosis","volume":"115","author":"Murrieta","year":"2021"},{"key":"b15","series-title":"Am J Trop Med Hyg","first-page":"78","article-title":"Natural history of treated subarachnoid neurocysticercosis","volume":"102","author":"Nash","year":"2020"}],"container-title":["The American Journal of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/108\/6\/article-p1188.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/108\/6\/article-p1188.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/108\/6\/article-p1188.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,7]],"date-time":"2023-06-07T13:07:24Z","timestamp":1686143244000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/108\/6\/article-p1188.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,7]]},"references-count":15,"journal-issue":{"issue":"6"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.22-0791","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"value":"0002-9637","type":"print"},{"value":"1476-1645","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,7]]}}}