{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T06:27:35Z","timestamp":1761719255322},"reference-count":37,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,1,3]]},"abstract":"<jats:title>ABSTRACT.<\/jats:title>\n<jats:p>Flea-borne typhus is a vector-borne disease caused by <jats:italic>Rickettsia typhi<\/jats:italic> that occurs worldwide, except in Antarctica. In the United States, most cases are restricted to California, Hawaii, and Texas. The syndrome is characterized by nonspecific signs and symptoms: fever, headache, rash, arthralgia, cough, hepatosplenomegaly, diarrhea, and abdominal pain. Although flea-borne typhus can cause pulmonary, neurological, and renal complications, the cardiovascular system is rarely affected. We present a case of endocarditis resulting from flea-borne typhus diagnosed by blood microbial cell-free DNA testing that required valve replacement and antibiotic therapy for 6 months. In addition, we review 20 cases of presumed and confirmed cardiovascular manifestations resulting from flea-borne typhus in the literature.<\/jats:p>","DOI":"10.4269\/ajtmh.22-0794","type":"journal-article","created":{"date-parts":[[2023,12,5]],"date-time":"2023-12-05T17:05:01Z","timestamp":1701795901000},"page":"150-154","source":"Crossref","is-referenced-by-count":2,"title":["Case Report: Cardiovascular Manifestations due to Flea-Borne Typhus"],"prefix":"10.4269","volume":"110","author":[{"given":"Christian","family":"Olivo-Freites","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases, David Geffen School of Medicine, University of California, Los Angeles, California;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kusha","family":"Davar","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, David Geffen School of Medicine, University of California, Los Angeles, California;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oscar","family":"Gallardo-Huizar","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Olive View Medical Center, University of California, Los Angeles, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tara","family":"Vijayan","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, David Geffen School of Medicine, University of California, Los Angeles, California;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramee","family":"Younes","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, David Geffen School of Medicine, University of California, Los Angeles, California;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2795","reference":[{"key":"b1","series-title":"Colomb Med (Cali)","first-page":"175","article-title":"Murine typhus: clinical and epidemiological aspects","volume":"43","author":"Peniche Lara","year":"2012"},{"key":"b2","series-title":"Res Rep Trop Med","first-page":"1","article-title":"Manifestations and management of flea-borne rickettsioses","volume":"12","author":"Caravedo Martinez","year":"2021"},{"key":"b3","series-title":"Infect Dis Clin North Am","first-page":"213","article-title":"The rickettsioses: a practical update","volume":"33","author":"Blanton","year":"2019"},{"key":"b4","series-title":"Trop Med Infect Dis","first-page":"37","article-title":"History, rats, fleas, and opossums: the ascendency of flea-borne typhus in the United States, 1910\u20131944","volume":"5","author":"Anstead","year":"2020"},{"key":"b5","series-title":"Trop Med Infect Dis","first-page":"2","article-title":"History, rats, fleas, and opossums: II. 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