{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T15:04:52Z","timestamp":1789139092132,"version":"build-2803163510"},"reference-count":23,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"2","license":[{"start":{"date-parts":[[2023,8,2]],"date-time":"2023-08-02T00:00:00Z","timestamp":1690934400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,8,2]]},"abstract":"<jats:title>ABSTRACT.<\/jats:title>\n<jats:p>Severe malaria after splenectomy has been reported with infections with <jats:italic>Plasmodium falciparum<\/jats:italic>, <jats:italic>Plasmodium knowlesi<\/jats:italic>, and <jats:italic>Plasmodium malariae,<\/jats:italic> but is less well-characterized with <jats:italic>Plasmodium vivax<\/jats:italic>. We describe a case of severe <jats:italic>P. vivax<\/jats:italic> malaria with hypotension, prostration, and acute kidney injury occurring 2 months after splenectomy in Papua, Indonesia. The patient was treated successfully with intravenous artesunate.<\/jats:p>","DOI":"10.4269\/ajtmh.23-0147","type":"journal-article","created":{"date-parts":[[2023,6,20]],"date-time":"2023-06-20T13:43:26Z","timestamp":1687268606000},"page":"284-287","source":"Crossref","is-referenced-by-count":5,"title":["Case Report: Severe Plasmodium vivax Malaria after Splenectomy"],"prefix":"10.4269","volume":"109","author":[{"given":"Noy Norman","family":"Kambuaya","sequence":"first","affiliation":[{"name":"Timika Malaria Research Facility, Papuan Health and Community Development Foundation, Timika, Papua, Indonesia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hasrini","family":"Rini","sequence":"additional","affiliation":[{"name":"Timika Malaria Research Facility, Papuan Health and Community Development Foundation, Timika, Papua, Indonesia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Putu Ayu Indra","family":"Shanti","sequence":"additional","affiliation":[{"name":"Rumah Sakit Umum Daerah Kabupaten Mimika, Timika, Papua, Indonesia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"King","family":"Alexander","sequence":"additional","affiliation":[{"name":"Rumah Sakit Umum Daerah Kabupaten Mimika, Timika, Papua, Indonesia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Freis","family":"Candrawati","sequence":"additional","affiliation":[{"name":"Timika Malaria Research Facility, Papuan Health and Community Development Foundation, Timika, Papua, Indonesia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pak","family":"Prayoga","sequence":"additional","affiliation":[{"name":"Timika Malaria Research Facility, Papuan Health and Community Development Foundation, Timika, Papua, Indonesia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leo","family":"Leonardo","sequence":"additional","affiliation":[{"name":"Timika Malaria Research Facility, Papuan Health and Community Development Foundation, Timika, Papua, Indonesia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dewi Sri","family":"Margayani","sequence":"additional","affiliation":[{"name":"Timika Malaria Research Facility, Papuan Health and Community Development Foundation, Timika, Papua, Indonesia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bagus Tesa Gina","family":"Yayang","sequence":"additional","affiliation":[{"name":"Timika Malaria Research Facility, Papuan Health and Community Development Foundation, Timika, Papua, Indonesia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enny","family":"Kenangalem","sequence":"additional","affiliation":[{"name":"Timika Malaria Research Facility, Papuan Health and Community Development Foundation, Timika, Papua, Indonesia;"},{"name":"Rumah Sakit Umum Daerah Kabupaten Mimika, Timika, Papua, Indonesia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre A.","family":"Buffet","sequence":"additional","affiliation":[{"name":"Institut Pasteur, University of Paris, Paris, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas M.","family":"Anstey","sequence":"additional","affiliation":[{"name":"Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, Australia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeanne Rini","family":"Poespoprodjo","sequence":"additional","affiliation":[{"name":"Timika Malaria Research Facility, Papuan Health and Community Development Foundation, Timika, Papua, Indonesia;"},{"name":"Rumah Sakit Umum Daerah Kabupaten Mimika, Timika, Papua, Indonesia;"},{"name":"Department of Pediatrics, Gadjah Mada University, Yogyakarta, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Kho","sequence":"additional","affiliation":[{"name":"Timika Malaria Research Facility, Papuan Health and Community Development Foundation, Timika, Papua, Indonesia;"},{"name":"Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, Australia;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"b1","series-title":"J Infect Dis","first-page":"1538","article-title":"Central role of the spleen in malaria parasite clearance","volume":"185","author":"Chotivanich","year":"2002"},{"key":"b2","series-title":"Trends Parasitol","first-page":"435","article-title":"The human spleen in malaria: filter or shelter?","volume":"36","author":"Henry","year":"2020"},{"key":"b3","series-title":"N Engl J Med","first-page":"2067","article-title":"Hidden biomass of intact malaria parasites in the human spleen","volume":"384","author":"Kho","year":"2021"},{"key":"b4","series-title":"PLoS Med","first-page":"e1003632","article-title":"Evaluation of splenic accumulation and colocalization of immature reticulocytes and Plasmodium vivax in asymptomatic malaria: a prospective human splenectomy study","volume":"18","author":"Kho","year":"2021"},{"key":"b5","series-title":"N Engl J Med","first-page":"1225","article-title":"Hazard of overwhelming infection after splenectomy in childhood","volume":"276","author":"Eraklis","year":"1967"},{"key":"b6","series-title":"Trans R Soc Trop Med Hyg","first-page":"861","article-title":"Falciparum malaria after splenectomy: a prospective controlled study of 33 previously splenectomized Malawian adults","volume":"99","author":"Bach","year":"2005"},{"key":"b7","series-title":"BMJ","first-page":"1273","article-title":"The incidence of malaria after splenectomy in Papua New Guinea","volume":"311","author":"Boone","year":"1995"},{"key":"b8","series-title":"Clin 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malaria in a splenectomized patient with beta-thalassaemia major in Sabah, Malaysia: a case report","volume":"15","author":"Bird","year":"2016"},{"key":"b13","series-title":"Arch Intern Med","first-page":"807","article-title":"Malaria complicating neoplastic disease","volume":"136","author":"Tapper","year":"1976"},{"key":"b14","author":"Kirchgatter","year":"2005"},{"key":"b15","series-title":"Trop Med Int Health","first-page":"7","article-title":"Severe malaria","volume":"19","year":"2014"},{"key":"b16","series-title":"Ann Trop Med Parasitol","first-page":"109","article-title":"Failure of chloroquine therapy in a splenectomized child infected with Plasmodium vivax.","volume":"96","author":"Singh","year":"2002"},{"key":"b17","series-title":"Blood Transfus","first-page":"428","article-title":"Dramatic post-splenectomy onset of malaria caused by latent Plasmodium vivax in a female immigrant with severe immunological 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Network","volume":"17","author":"Hossain","year":"2020"},{"key":"b22","series-title":"J Infect Dis","first-page":"1557","article-title":"Nitric oxide-dependent endothelial dysfunction and reduced arginine bioavailability in Plasmodium vivax malaria but no greater increase in intravascular hemolysis in severe disease","volume":"214","author":"Barber","year":"2016"},{"key":"b23","series-title":"Blood","first-page":"1332","article-title":"Platelets kill circulating parasites of all major Plasmodium species in human malaria","volume":"132","author":"Kho","year":"2018"}],"container-title":["The American Journal of Tropical Medicine and 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