{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T20:45:02Z","timestamp":1783543502690,"version":"3.55.0"},"reference-count":65,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"6","license":[{"start":{"date-parts":[[2024,6,5]],"date-time":"2024-06-05T00:00:00Z","timestamp":1717545600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,6,5]]},"abstract":"<jats:title>ABSTRACT.<\/jats:title>\n<jats:p>Glucose-6 phosphate dehydrogenase deficiency (G6PDd) was suggested as a risk factor for severe disease in patients with COVID-19. We evaluated clinical outcomes and glucose-6 phosphate dehydrogenase (G6PD) activity during and after illness in patients with COVID-19. This prospective cohort study included adult participants (\u2265\u00a018\u2009years old) who had clinical and\/or radiological COVID-19 findings or positive reverse transcription\u2013polymerase chain reaction results. Epidemiological and clinical data were extracted from electronic medical records. Glucose-6 phosphate dehydrogenase activity was measured using SD Biosensor STANDARD G6PD<jats:sup>\u00ae<\/jats:sup> equipment on admission and 1\u2009year after discharge. Samples were genotyped for the three most common single nucleotide polymorphisms for G6PDd in the Brazilian Amazon. Seven hundred fifty-three patients were included, of whom 123 (16.3%) were G6PD deficient. There was no difference between groups regarding the risks of hospitalization (<jats:italic>P =<\/jats:italic> 0.740) or invasive mechanical ventilation (<jats:italic>P =<\/jats:italic> 0.31), but the risk of death was greater in patients with normal G6PD levels (<jats:italic>P =<\/jats:italic> 0.022). Only 29 of 116 participants (25%) carried the African G6PDd genotype. Of 30 participants tested as G6PD deficient during disease, only 11 (36.7%) results agreed 1\u2009year after discharge. In conclusion, this study does not demonstrate an association of G6PDd with severity of COVID-19. Limitations of the test for detecting enzyme levels during COVID-19 illness were demonstrated by genotyping and retesting after the disease period. Care must be taken when screening for G6PDd in patients with acute COVID-19.<\/jats:p>","DOI":"10.4269\/ajtmh.23-0148","type":"journal-article","created":{"date-parts":[[2024,4,9]],"date-time":"2024-04-09T17:48:36Z","timestamp":1712684916000},"page":"1191-1197","source":"Crossref","is-referenced-by-count":4,"title":["Associations between COVID-19 and Glucose-6-Phosphate Dehydrogenase Activity in Brazil"],"prefix":"10.4269","volume":"110","author":[{"given":"Maria Gabriela","family":"de Almeida Rodrigues","sequence":"first","affiliation":[{"name":"Universidade do Estado do Amazonas, Manaus, Brazil;"},{"name":"Department of Education and Research, Funda\u00e7\u00e3o de Medicina Tropical Dr. Heitor Vieira Dourado, Manaus, Brazil;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wuelton Marcelo","family":"Monteiro","sequence":"additional","affiliation":[{"name":"Universidade do Estado do Amazonas, Manaus, Brazil;"},{"name":"Department of Education and Research, Funda\u00e7\u00e3o de Medicina Tropical Dr. Heitor Vieira Dourado, Manaus, Brazil;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gisely Cardoso","family":"de Melo","sequence":"additional","affiliation":[{"name":"Universidade do Estado do Amazonas, Manaus, Brazil;"},{"name":"Department of Education and Research, Funda\u00e7\u00e3o de Medicina Tropical Dr. Heitor Vieira Dourado, Manaus, Brazil;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1dila Liliane Barros","family":"Dias","sequence":"additional","affiliation":[{"name":"Universidade do Estado do Amazonas, Manaus, Brazil;"},{"name":"Department of Education and Research, Funda\u00e7\u00e3o de Medicina Tropical Dr. Heitor Vieira Dourado, Manaus, Brazil;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco Aur\u00e9lio","family":"Sartim","sequence":"additional","affiliation":[{"name":"Department of Postgraduate, Research and Innovation, Universidade Nilton Lins, Manaus, Brazil;"},{"name":"Institute of Biological Sciences, Universidade Federal do Amazonas, Manaus, Brazil;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana Sim\u00e3o","family":"Xavier","sequence":"additional","affiliation":[{"name":"Clinical Research Laboratory for Acute Febrile Illnesses, Instituto Nacional de Infectologia Carlos Chagas, Rio de Janeiro, Brazil;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebeca Linhares Abreu","family":"Netto","sequence":"additional","affiliation":[{"name":"Universidade do Estado do Amazonas, Manaus, Brazil;"},{"name":"Department of Education and Research, Funda\u00e7\u00e3o de Medicina Tropical Dr. Heitor Vieira Dourado, Manaus, Brazil;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando Fonseca","family":"Almeida","sequence":"additional","affiliation":[{"name":"Universidade do Estado do Amazonas, Manaus, Brazil;"},{"name":"Department of Education and Research, Funda\u00e7\u00e3o de Medicina Tropical Dr. Heitor Vieira Dourado, Manaus, Brazil;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Djane Clarys","family":"Ba\u00eda-da-Silva","sequence":"additional","affiliation":[{"name":"Universidade do Estado do Amazonas, Manaus, Brazil;"},{"name":"Department of Education and Research, Funda\u00e7\u00e3o de Medicina Tropical Dr. Heitor Vieira Dourado, Manaus, Brazil;"},{"name":"Department of Postgraduate, Research and Innovation, Universidade Nilton Lins, Manaus, Brazil;"},{"name":"Institute of Biological Sciences, Universidade Federal do Amazonas, Manaus, Brazil;"},{"name":"Instituto Le\u00f4nidas e Maria Deane\/Fiocruz Amaz\u00f4nia, Instituto de Pesquisas Cl\u00ednicas Carlos Borborema, Manaus, Brazil;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Diego","family":"Brito-Sousa","sequence":"additional","affiliation":[{"name":"Universidade do Estado do Amazonas, Manaus, Brazil;"},{"name":"Department of Education and Research, Funda\u00e7\u00e3o de Medicina Tropical Dr. Heitor Vieira Dourado, Manaus, Brazil;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus Vinicius Guimar\u00e3es","family":"de Lacerda","sequence":"additional","affiliation":[{"name":"Universidade do Estado do Amazonas, Manaus, Brazil;"},{"name":"Department of Education and Research, Funda\u00e7\u00e3o de Medicina Tropical Dr. Heitor Vieira Dourado, Manaus, Brazil;"},{"name":"Instituto Le\u00f4nidas e Maria Deane\/Fiocruz Amaz\u00f4nia, Instituto de Pesquisas Cl\u00ednicas Carlos Borborema, Manaus, Brazil;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanderson","family":"de Souza Sampaio","sequence":"additional","affiliation":[{"name":"Department of Education and Research, Funda\u00e7\u00e3o de Medicina Tropical Dr. Heitor Vieira Dourado, Manaus, Brazil;"},{"name":"Funda\u00e7\u00e3o de Vigil\u00e2ncia em Sa\u00fade do Amazonas, Manaus, Brazil;"},{"name":"Instituto Todos pela Sa\u00fade, S\u00e3o 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