{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T08:03:48Z","timestamp":1769155428074,"version":"3.49.0"},"reference-count":38,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,8,2]]},"abstract":"<jats:title>ABSTRACT.<\/jats:title>\n<jats:p><jats:italic>Cedecea lapagei<\/jats:italic> is a gram-negative, non-encapsulated, facultative anaerobic bacterium that has been reported in only a few cases with varying clinical presentations, drug susceptibility, and treatment since its first isolation in 1981. This study aimed to describe a case report of <jats:italic>C. lapagei<\/jats:italic> in Peru and systematically review the documented case reports of individuals infected with <jats:italic>C. lapagei<\/jats:italic>. A 59-year-old man who had become bedridden with Parkinson\u2019s disease and had epilepsy presented with a 1-week history of fever and sore throat and was admitted. Physical examination revealed an obtundation state and abolished vesicular murmur in the right hemithorax. During hospitalization, the patient was diagnosed with various infections, including tuberculosis, for which he received broad-spectrum antibiotics. In the absence of clinical improvement, a urine culture was performed showing <jats:italic>C. lapagei<\/jats:italic> (detected by BD Phoenix M50 system, Vernon Hills, IL). The patient received amoxicillin\/clavulanate and was discharged. Case reports of <jats:italic>C. lapagei<\/jats:italic> were also searched in five databases on January 28, 2023. Twenty cases of <jats:italic>C. lapagei<\/jats:italic> were reported worldwide between 2006 and 2022, 16 of which involved adults. Fever was the most common manifestation (75%), and pneumonia was the primary form of presentation (45%). Moreover, 90% of the patients had at least one comorbidity, and 15% died. Also, most of the isolates were sensitive to ciprofloxacin (81%), meropenem (62%), and amikacin (60%). Overall, <jats:italic>C. lapagei<\/jats:italic> should be suspected in compromised hosts, particularly those with pneumonia. Although the bacterium can affect various organs and the antibiotic susceptibility pattern is variable, quinolones, tetracyclines, and carbapenems seem to be the first therapeutic option.<\/jats:p>","DOI":"10.4269\/ajtmh.23-0168","type":"journal-article","created":{"date-parts":[[2023,6,20]],"date-time":"2023-06-20T13:43:32Z","timestamp":1687268612000},"page":"356-367","source":"Crossref","is-referenced-by-count":4,"title":["Case Report: Cedecea lapagei Infection: Report of a Case in Peru and Review of the Literature"],"prefix":"10.4269","volume":"109","author":[{"given":"Ali","family":"Al-kassab-C\u00f3rdova","sequence":"first","affiliation":[{"name":"Centro de Excelencia en Estudios Econ\u00f3micos y Sociales en Salud, Universidad San Ignacio de Loyola, Lima, Peru;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia","family":"Valdiviezo-Polo","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias de la Salud, Universidad Peruana de Ciencias Aplicadas, Lima, Peru;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan R.","family":"Ulloque-Badaracco","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias de la Salud, Universidad Peruana de Ciencias Aplicadas, Lima, Peru;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos L.","family":"Honorio-Arroyo","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias de la Salud, Universidad Peruana de Ciencias Aplicadas, Lima, Peru;"},{"name":"Hospital de Emergencias Jos\u00e9 Casimiro Ulloa, Ministerio de Salud, Lima, Peru;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel","family":"Hueda-Zavaleta","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias de la Salud, Universidad Privada de Tacna, Tacna, Peru;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vicente A.","family":"Benites-Zapata","sequence":"additional","affiliation":[{"name":"Maestr\u00eda de Epidemiolog\u00eda Cl\u00ednica y Bioestad\u00edstica, Universidad Cient\u00edfica del Sur, Lima, Peru"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2795","reference":[{"key":"b1","series-title":"Int J Syst Bacteriol","first-page":"317","article-title":"Cedecea davisae gen. nov., sp. nov. and Cedecea lapagei sp. nov., new Enterobacteriaceae from clinical specimens","volume":"31","author":"Grimont","year":"1981"},{"key":"b2","series-title":"Diagn Microbiol Infect Dis","first-page":"303","article-title":"Bacteraemia due to Cedecea davisae in a patient with sigmoid colon cancer: a case report and brief review of the literature","volume":"74","author":"Akinosoglou","year":"2012"},{"key":"b3","series-title":"Encyclopedia of Food Safety","first-page":"433","author":"Cooney","year":"2014"},{"key":"b4","series-title":"Perit Dial Int","first-page":"512","article-title":"\u201cBroom straw peritonitis\u201d secondary to Cedecea lapagei in a liver transplant 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