{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T13:13:24Z","timestamp":1787318004146,"version":"build-2736575974"},"reference-count":37,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"1","license":[{"start":{"date-parts":[[2024,1,3]],"date-time":"2024-01-03T00:00:00Z","timestamp":1704240000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,1,3]]},"abstract":"<jats:title>ABSTRACT.<\/jats:title>\n                  <jats:p>\n                    The first nationally representative, population-based study of schistosomiasis seroprevalence in Nigeria was conducted using blood samples and risk-factor data collected during the 2018 Nigeria HIV\/AIDS Indicator and Impact Survey (NAIIS). Schistosomiasis seroprevalence was estimated by analyzing samples for reactivity to schistosome soluble egg antigen (SEA) in a multiplex bead assay; NAIIS survey data were assessed to identify potential risk factors for seropositivity. The SEA antibody data were available for 31,459 children aged 0 to 14\u2009years. Overall seroprevalence was 17.2% (95% CI: 16.3\u201318.1%). Seropositive children were identified in every age group, including children &lt; 5\u2009years, and seroprevalence increased with increasing age (\n                    <jats:italic>P &lt;<\/jats:italic>\n                    0.0001). Several factors were associated with increased odds of seropositivity, including being a boy (odds ratio [OR] = 1.34, 95% CI: 1.24\u20131.45), living in a rural area (OR = 2.2, 95% CI: 1.9\u20132.5), and animal ownership (OR = 1.67, 95% CI: 1.52\u20131.85). Access to improved sanitation and drinking water sources were associated with decreased odds of seropositivity (OR = 0.52, 95% CI: 0.47\u20130.58 and OR = 0.53, 95% CI: 0.47\u20130.60, respectively) regardless of whether the child lived in a rural (sanitation: adjusted odds ratio [aOR] = 0.7, 95% CI: 0.6\u20130.8; drinking water: aOR = 0.7, 95% CI: 0.6\u20130.8) or urban area (sanitation: aOR = 0.6, 95% CI: 0.5\u20130.7; drinking water: aOR = 0.5, 95% CI: 0.4\u20130.6), highlighting the importance of these factors for schistosomiasis prevention and control. These results identified additional risk populations (children &lt; 5\u2009years) and a new risk factor (animal ownership) and could be used to monitor the impact of control programs.\n                  <\/jats:p>","DOI":"10.4269\/ajtmh.23-0219","type":"journal-article","created":{"date-parts":[[2023,11,27]],"date-time":"2023-11-27T13:07:21Z","timestamp":1701090441000},"page":"90-97","source":"Crossref","is-referenced-by-count":4,"title":["Schistosomiasis Seroprevalence among Children Aged 0\u201314 Years in Nigeria, 2018"],"prefix":"10.4269","volume":"110","author":[{"given":"Anne","family":"Straily","sequence":"first","affiliation":[{"name":"Division of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention, Atlanta, Georgia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Israel","family":"Tamunonengiyeofori","sequence":"additional","affiliation":[{"name":"Nigeria Centre for Disease Control and Prevention, Abuja, Nigeria;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan E.","family":"Wiegand","sequence":"additional","affiliation":[{"name":"Division of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention, Atlanta, Georgia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nnaemeka C.","family":"Iriemenam","sequence":"additional","affiliation":[{"name":"Division of Global HIV and TB, Centers for Disease Control and Prevention, Abuja, Nigeria;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"McPaul I.","family":"Okoye","sequence":"additional","affiliation":[{"name":"Division of Global HIV and TB, Centers for Disease Control and Prevention, Abuja, Nigeria;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayuba B.","family":"Dawurung","sequence":"additional","affiliation":[{"name":"Institute of Human Virology, Abuja, Nigeria;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nkechi Blessing","family":"Ugboaja","sequence":"additional","affiliation":[{"name":"Institute of Human Virology, Abuja, Nigeria;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martha","family":"Tongha","sequence":"additional","affiliation":[{"name":"Institute of Human Virology, Abuja, Nigeria;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nishanth","family":"Parameswaran","sequence":"additional","affiliation":[{"name":"Division of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention, Atlanta, Georgia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stacie M.","family":"Greby","sequence":"additional","affiliation":[{"name":"Division of Global HIV and TB, Centers for Disease Control and Prevention, Abuja, Nigeria;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Alagi","sequence":"additional","affiliation":[{"name":"Division of Global HIV and TB, Centers for Disease Control and Prevention, Abuja, Nigeria;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nseobong M.","family":"Akpan","sequence":"additional","affiliation":[{"name":"Neglected Tropical Diseases, Federal Ministry of Health, Abuja, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William E.","family":"Nwachukwu","sequence":"additional","affiliation":[{"name":"Nigeria Centre for Disease Control and Prevention, Abuja, Nigeria;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nwando","family":"Mba","sequence":"additional","affiliation":[{"name":"Nigeria Centre for Disease Control and Prevention, Abuja, Nigeria;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana L.","family":"Martin","sequence":"additional","affiliation":[{"name":"Division of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention, Atlanta, Georgia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. Evan","family":"Secor","sequence":"additional","affiliation":[{"name":"Division of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention, Atlanta, Georgia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahesh","family":"Swaminathan","sequence":"additional","affiliation":[{"name":"Division of Global HIV and TB, Centers for Disease Control and Prevention, Abuja, Nigeria;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ifedayo","family":"Adetifa","sequence":"additional","affiliation":[{"name":"Nigeria Centre for Disease Control and Prevention, Abuja, Nigeria;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chikwe","family":"Ihekweazu","sequence":"additional","affiliation":[{"name":"Nigeria Centre for Disease Control and Prevention, Abuja, Nigeria;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"b1","series-title":"PLoS Negl Trop Dis","first-page":"e1600","article-title":"Nigeria: \u201cGround Zero\u201d for the high prevalence neglected tropical diseases","volume":"6","author":"Hotez","year":"2012"},{"key":"b2","series-title":"PLoS Negl Trop Dis","first-page":"e412","article-title":"Neglected tropical diseases in sub-Saharan Africa: review of their prevalence, distribution, and disease burden","volume":"3","author":"Hotez","year":"2009"},{"key":"b3","series-title":"Geospat Health","first-page":"355","article-title":"Mapping and prediction of schistosomiasis in Nigeria using compiled survey data and Bayesian geospatial modelling","volume":"7","author":"Ekpo","year":"2013"},{"key":"b4","series-title":"Lancet","first-page":"2253","article-title":"Human schistosomiasis","volume":"383","author":"Colley","year":"2014"},{"key":"b5","series-title":"Basic Laboratory Methods in Medical Parasitology","year":"1991"},{"key":"b6","series-title":"Am J Trop Med Hyg","first-page":"1233","article-title":"Cost analysis of tests for the detection of Schistosoma mansoni infection in children in western Kenya","volume":"92","author":"Worrell","year":"2015"},{"key":"b7","series-title":"PLoS One","first-page":"e0226586","article-title":"Cost and logistics implications of a nationwide survey of schistosomiasis and other intestinal helminthiases in Sudan: key activities and cost components","volume":"15","author":"Elhag","year":"2020"},{"key":"b8","series-title":"PLoS Negl Trop Dis","first-page":"e779","article-title":"The global atlas of helminth infection: mapping the way forward in neglected tropical disease control","volume":"4","author":"Brooker","year":"2010"},{"key":"b9","series-title":"Proc Natl Acad Sci USA","first-page":"23174","article-title":"Fine-scale heterogeneity in Schistosoma mansoni force of infection measured through antibody response","volume":"117","author":"Arnold","year":"2020"},{"key":"b10","series-title":"Int J Parasitol","first-page":"797","article-title":"Development of a new platform for 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man","volume":"29","author":"Hillyer","year":"1980"},{"key":"b15","series-title":"J Clin Pathol","first-page":"1193","article-title":"Serological speciation of human schistosome infections by ELISA with a panel of three antigens","volume":"57","author":"Turner","year":"2004"},{"key":"b16","series-title":"Core Questions on Drinking Water, Sanitation and Hygiene for Household Surveys: 2018 Update","year":"2018"},{"key":"b17","series-title":"Parasit Vectors","first-page":"156","article-title":"The roles of water, sanitation and hygiene in reducing schistosomiasis: a review","volume":"8","author":"Grimes","year":"2015"},{"key":"b18","series-title":"The DHS Wealth Index","author":"Rutstein","year":"2004"},{"key":"b19","series-title":"Nigeria HIV\/AIDS Indicator and Impact Survey (NAIIS) 2018: Data Use Manual","year":"2020"},{"key":"b20","series-title":"Ann Stat","first-page":"385","article-title":"On simple adjustments to Chi-square tests with sample survey data","volume":"15","author":"Rao","year":"1987"},{"key":"b21","series-title":"Int Stat Rev","first-page":"279","article-title":"On the variances of asymptotically normal estimators from complex surveys","volume":"51","author":"Binder","year":"1983"},{"key":"b22","series-title":"Pathog Glob Health","first-page":"76","article-title":"Epidemiological dynamics and associated risk factors of S. haematobium in humans and its snail vectors in Nigeria: a meta-analysis (1983-2018)","volume":"114","author":"Odeniran","year":"2020"},{"key":"b23","series-title":"PLoS One","first-page":"e71635","article-title":"Use of geospatial modeling to predict Schistosoma mansoni prevalence in Nyanza Province, Kenya","volume":"8","author":"Woodhall","year":"2013"},{"key":"b24","series-title":"J Trop Med","first-page":"6913918","article-title":"Urogenital schistosomiasis among schoolchildren and the associated risk factors in selected rural communities of Kwara State, Nigeria","volume":"2018","author":"Abdulkareem","year":"2018"},{"key":"b25","series-title":"Trop Med Int Health","first-page":"612","article-title":"Association between socio economic status and schistosomiasis infection in Jinja District, Uganda","volume":"14","author":"Muhumuza","year":"2009"},{"key":"b26","series-title":"Parasit Vectors","first-page":"58","article-title":"Urinary schistosomiasis among preschool children in a rural community near Abeokuta, Nigeria","volume":"3","author":"Ekpo","year":"2010"},{"key":"b27","series-title":"Front Immunol","first-page":"1402","article-title":"Impact of mothers\u2019 schistosomiasis status during gestation on children\u2019s IgG antibody responses to routine vaccines 2\u2009years later and anti-schistosome and anti-malarial responses by neonates in Western Kenya","volume":"9","author":"Ondigo","year":"2018"},{"key":"b28","series-title":"One Health","first-page":"100183","article-title":"Schistosomiasis in Nigeria: gleaning from the past to 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When to suspect it and what to do about it","volume":"39","author":"Bustinduy","year":"2020"},{"key":"b37","series-title":"WHO Guideline on Control and Elimination of Human Schistosomiasis","year":"2022"}],"container-title":["The American Journal of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/110\/1\/article-p90.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/110\/1\/article-p90.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/110\/1\/article-p90.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,3]],"date-time":"2024-01-03T13:15:53Z","timestamp":1704287753000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/110\/1\/article-p90.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,3]]},"references-count":37,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.23-0219","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"value":"0002-9637","type":"print"},{"value":"1476-1645","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,3]]}}}