{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T16:55:14Z","timestamp":1791824114444,"version":"4.3.4"},"reference-count":28,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"6","license":[{"start":{"date-parts":[[2023,12,6]],"date-time":"2023-12-06T00:00:00Z","timestamp":1701820800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,12,6]]},"abstract":"<jats:title>ABSTRACT.<\/jats:title>\n<jats:p><jats:italic>Macacine alphaherpesvirus<\/jats:italic> 1, also known as herpes B virus (BV), is an alphaherpesvirus endemic to several macaque species, capable of causing zoonotic infections in humans, with high mortality rates. Evidence of reactivation in humans has rarely been reported. Here we depict a case of BV reactivation after 54\u2009years, leading to severe meningoencephalitis. This case supports the use of antiviral prophylaxis in patients surviving a confirmed BV central nervous system infection. We sequenced DNA from BV obtained from the patient\u2019s cerebrospinal fluid. Phylogenetic analysis showed significant divergence in the clustering of this particular BV strain compared with other known BVs. Therefore, additional efforts are needed to obtain a broader sequence landscape from BVs circulating in monkeys.<\/jats:p>","DOI":"10.4269\/ajtmh.23-0253","type":"journal-article","created":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T16:29:28Z","timestamp":1697473768000},"page":"1277-1281","source":"Crossref","is-referenced-by-count":6,"title":["Case Report: Late Reactivation of Herpes B Virus After a Monkey Bite: A Case of Severe Meningoencephalitis"],"prefix":"10.4269","volume":"109","author":[{"given":"Ester","family":"Ponzetto","sequence":"first","affiliation":[{"name":"Intensive Care Unit, Clinique Saint-Pierre, Ottignies, Belgium;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quentin","family":"Delhez","sequence":"additional","affiliation":[{"name":"Intensive Care Unit, Clinique Saint-Pierre, Ottignies, Belgium;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maarten","family":"Hoppenbrouwers","sequence":"additional","affiliation":[{"name":"Department of Viroscience, Erasmus MC, Rotterdam, The Netherlands;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"De Schryver","sequence":"additional","affiliation":[{"name":"Intensive Care Unit, Clinique Saint-Pierre, Ottignies, Belgium;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Serck","sequence":"additional","affiliation":[{"name":"Intensive Care Unit, Clinique Saint-Pierre, Ottignies, Belgium;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"Dugernier","sequence":"additional","affiliation":[{"name":"Intensive Care Unit, Clinique Saint-Pierre, Ottignies, Belgium;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-C\u00e9line","family":"Duray","sequence":"additional","affiliation":[{"name":"Department of Neurology, Clinique Saint-Pierre, Ottignies, Belgium;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Gressens","sequence":"additional","affiliation":[{"name":"Intensive Care Unit, Clinique Saint-Pierre, Ottignies, Belgium;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Vinetti","sequence":"additional","affiliation":[{"name":"Intensive Care Unit, Clinique Saint-Pierre, Ottignies, Belgium;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregorius J.","family":"Sips","sequence":"additional","affiliation":[{"name":"Department of Viroscience, Erasmus MC, Rotterdam, The Netherlands;"},{"name":"Public Health Service Rotterdam-Rijnmond, Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeroen","family":"van Kampen","sequence":"additional","affiliation":[{"name":"Department of Viroscience, Erasmus MC, Rotterdam, The Netherlands;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corine H.","family":"GeurtsvanKessel","sequence":"additional","affiliation":[{"name":"Department of Viroscience, Erasmus MC, Rotterdam, The Netherlands;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sander","family":"van Boheemen","sequence":"additional","affiliation":[{"name":"Department of Viroscience, Erasmus MC, Rotterdam, The Netherlands;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"b1","series-title":"Human Herpesviruses: Biology, Therapy, and Immunoprophylaxis","author":"Hilliard"},{"key":"b2","series-title":"Ann Intern Med","first-page":"833","article-title":"B virus (Herpesvirus simiae) infection in humans: epidemiologic investigation of a cluster","volume":"112","author":"Holmes","year":"1990"},{"key":"b3","series-title":"Clin Infect Dis","first-page":"555","article-title":"Biology of B virus in macaque and human hosts: a review","volume":"14","author":"Weigler","year":"1992"},{"key":"b4","series-title":"J Exp Med","first-page":"115","article-title":"Acute ascending myelitis following a monkey bite, with the isolation of a virus capable of reproducing the disease","volume":"59","author":"Sabin","year":"1934"},{"key":"b5","series-title":"BMJ","first-page":"22","article-title":"Monkey-bite encephalomyelitis; report of a case; with recovery","volume":"2","author":"Breen","year":"1958"},{"key":"b6","series-title":"Arch Intern Med","first-page":"868","article-title":"Recovery from encephalomyelitis caused by Herpesvirus simiae. 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description and diagnosis of a fatal human infection","volume":"68","author":"Pierce","year":"1958"},{"key":"b27","series-title":"Invest Ophthalmol Vis Sci","first-page":"2975","article-title":"Case report: reactivation of latent B virus (Macacine herpesvirus 1) presenting as bilateral uveitis, retinal vasculitis and necrotizing herpetic retinitis","volume":"52","author":"Calvo","year":"2011"},{"key":"b28","series-title":"PLoS One","first-page":"e0182355","article-title":"Identification of unique B virus (Macacine Herpesvirus 1) epitopes of zoonotic and macaque isolates using monoclonal antibodies","volume":"12","author":"Katz","year":"2017"}],"container-title":["The American Journal of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/109\/6\/article-p1277.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/109\/6\/article-p1277.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/109\/6\/article-p1277.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,6]],"date-time":"2023-12-06T15:45:23Z","timestamp":1701877523000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/109\/6\/article-p1277.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,6]]},"references-count":28,"journal-issue":{"issue":"6"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.23-0253","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"value":"0002-9637","type":"print"},{"value":"1476-1645","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,6]]}}}