{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:10:31Z","timestamp":1791227431703,"version":"4.1.0"},"reference-count":24,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"1","license":[{"start":{"date-parts":[[2024,1,3]],"date-time":"2024-01-03T00:00:00Z","timestamp":1704240000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,1,3]]},"abstract":"<jats:title>ABSTRACT.<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Brugia malayi<\/jats:italic>\n                    is the major cause of lymphatic filariasis (LF) in Indonesia. Zoophilic\n                    <jats:italic>B. malayi<\/jats:italic>\n                    was endemic in Belitung district, and mass drug administration (MDA) with diethylcarbamazine (DEC) and albendazole ceased after five annual rounds in 2010. The district passed three transmission assessment surveys (TAS) between 2011 and 2016. As part of the post-TAS3 surveillance of the national LF elimination program, we collected night blood samples for microfilaria (Mf) detection from 1,911 subjects more than 5\u2009years of age in seven villages. A\n                    <jats:italic>B. malayi<\/jats:italic>\n                    Mf prevalence ranging from 1.7% to 5.9% was detected in five villages. Only 2 (5%) of the total 40 Mf-positive subjects were adolescents aged 18 and 19\u2009years old, and 38 (95%) Mf-positive subjects were 21\u2009years and older. Microfilarial densities in infected individuals were mostly low, with 60% of the subjects having Mf densities between 16 and 160 Mf\/mL. Triple-drug treatment with ivermectin, DEC, and albendazole (IDA) was given to 36 eligible Mf-positive subjects. Adverse events were mostly mild, and treatment was well tolerated. One year later, 35 of the treated Mf-positive subjects were reexamined, and 33 (94%) had cleared all Mf, while the anti-Bm14 antibody prevalence remained almost unchanged. Results indicate that in\n                    <jats:italic>B. malayi<\/jats:italic>\n                    -endemic areas, post-TAS3 surveillance for Mf in the community may be needed to detect a potential parasite reservoir in adults. Selective treatment with IDA is highly effective in clearing\n                    <jats:italic>B. malayi<\/jats:italic>\n                    Mf and should be used to increase the prospects for LF elimination if MDA is reintroduced.\n                  <\/jats:p>","DOI":"10.4269\/ajtmh.23-0255","type":"journal-article","created":{"date-parts":[[2024,1,3]],"date-time":"2024-01-03T13:14:24Z","timestamp":1704287664000},"page":"111-116","source":"Crossref","is-referenced-by-count":13,"title":["Surveillance and Selective Treatment of Brugia malayi Filariasis Eleven Years after Stopping Mass Drug Administration in Belitung District, Indonesia"],"prefix":"10.4269","volume":"110","author":[{"given":"Taniawati","family":"Supali","sequence":"first","affiliation":[{"name":"Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yenny","family":"Djuardi","sequence":"additional","affiliation":[{"name":"Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Santoso","sequence":"additional","affiliation":[{"name":"Baturaja Unit for Health Research and Development, National Institute of Health Research and Development, Ministry of Health of Indonesia, South Sumatra, Indonesia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lita Renata","family":"Sianipar","sequence":"additional","affiliation":[{"name":"Directorate of Communicable Disease, Prevention, and Control, Indonesia Ministry of Health, Jakarta, Indonesia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nungki Hapsari","family":"Suryaningtyas","sequence":"additional","affiliation":[{"name":"Baturaja Unit for Health Research and Development, National Institute of Health Research and Development, Ministry of Health of Indonesia, South Sumatra, Indonesia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahmat","family":"Alfian","sequence":"additional","affiliation":[{"name":"Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yossi","family":"Destani","sequence":"additional","affiliation":[{"name":"Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Iskandar","sequence":"additional","affiliation":[{"name":"Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hendri","family":"Astuty","sequence":"additional","affiliation":[{"name":"Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noviani","family":"Sugianto","sequence":"additional","affiliation":[{"name":"Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter U.","family":"Fischer","sequence":"additional","affiliation":[{"name":"Infectious Diseases Division, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"b1","year":"2019"},{"key":"b2","series-title":"Global Programme to Eliminate Lymphatic Filariasis: Monitoring and Epidemiological Assessment of Mass Drug Administration","year":"2011"},{"key":"b3","year":"2017"},{"key":"b4","series-title":"Korean J Parasitol","first-page":"627","article-title":"Risk of recrudescence of lymphatic filariasis after post-MDA surveillance in 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endemic populations in East Africa","volume":"161","author":"Damgaard","year":"2016"},{"key":"b18","series-title":"J Infect Dis","first-page":"1630","article-title":"Reduced antifilarial IgG4 responsiveness in a subpopulation of microfilaremic persons","volume":"172","author":"Marley","year":"1995"},{"key":"b19","series-title":"J Helminthol","first-page":"363","article-title":"Diagnostic value of IgG isotype responses against Brugia malayi antifilarial antibodies in the clinical spectrum of brugian filariasis","volume":"80","author":"Wongkamchai","year":"2006"},{"key":"b20","series-title":"J Clin Invest","first-page":"1403","article-title":"Immunologic tolerance in lymphatic filariasis. Diminished parasite-specific T and B lymphocyte precursor frequency in the microfilaremic state","volume":"89","author":"King","year":"1992"},{"key":"b21","series-title":"N Engl J Med","first-page":"1801","article-title":"A trial of a triple-drug treatment for lymphatic filariasis","volume":"379","author":"King","year":"2018"},{"key":"b22","series-title":"N Engl J Med","first-page":"1956","article-title":"Single-dose triple-drug therapy for Wuchereria bancrofti \u2013 5-year follow-up","volume":"382","author":"King","year":"2020"},{"key":"b23","series-title":"PLoS Negl Trop Dis","first-page":"e0009294","article-title":"An open label, randomized clinical trial to compare the tolerability and efficacy of ivermectin plus diethylcarbamazine and albendazole vs. diethylcarbamazine plus albendazole for treatment of brugian filariasis in Indonesia","volume":"15","author":"Supali","year":"2021"},{"key":"b24","series-title":"Wkly Epidemiol Rec","first-page":"513","article-title":"Global programme to eliminate lymphatic filariasis: progress report, 2021","volume":"41","year":"2022"}],"container-title":["The American Journal of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/110\/1\/article-p111.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/110\/1\/article-p111.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/110\/1\/article-p111.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,3]],"date-time":"2024-01-03T13:14:24Z","timestamp":1704287664000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/110\/1\/article-p111.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,3]]},"references-count":24,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.23-0255","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"value":"0002-9637","type":"print"},{"value":"1476-1645","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,3]]}}}