{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:39:25Z","timestamp":1790775565772,"version":"4.1.0"},"reference-count":31,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,12,6]]},"abstract":"<jats:title>ABSTRACT.<\/jats:title>\n                  <jats:p>\n                    The global burden of dengue infections has increased dramatically. Early diagnosis of dengue infection is critical to proper medical management to avoid further complications in patients. This study was geared to assess the severity of dengue infections based on clinical and hematological examinations. A cross-sectional study was conducted among febrile patients with dengue infection in a teaching hospital in Pakistan. Blood samples were investigated for dengue-specific antibodies (IgM and IgG) and the nonstructural 1 antigen. The clinical findings of each subject were noted to assess the severity of the infection. Tests for hematological parameters were performed. Of 130 patients with confirmed dengue infection, 23 had severe and 107 had nonsevere dengue. Patients with severe dengue experienced mucosal bleeding (71.4%), fluid accumulation (57.1%), shock (35.7%), and gastrointestinal bleeding (28.6%). The most significant hematological findings among severe and nonsevere patients with dengue infection were thrombocytopenia, leukopenia, and a raised hematocrit level (\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.001). Patients with severe dengue infection showed marked thrombocytopenia, with a mean platelet count of 49.96 \u00d7 10\n                    <jats:sup>9<\/jats:sup>\n                    platelets\/L. The clinical presentation of patients with dengue infection along with hematological markers are the most important clues for the diagnosis of, prognosis of, and therapy for dengue infection. Thrombocytopenia, leukopenia, and raised hematocrit levels were the most significant hematological parameters when assessing the severity of dengue infection.\n                  <\/jats:p>","DOI":"10.4269\/ajtmh.23-0309","type":"journal-article","created":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T08:44:00Z","timestamp":1698050640000},"page":"1284-1289","source":"Crossref","is-referenced-by-count":11,"title":["Severity of Dengue Viral Infection Based on Clinical and Hematological Parameters among Pakistani Patients"],"prefix":"10.4269","volume":"109","author":[{"given":"Faiz Ul","family":"Haq","sequence":"first","affiliation":[{"name":"Department of Microbiology, University of Health Sciences, Lahore, Pakistan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Imran","sequence":"additional","affiliation":[{"name":"Department of Microbiology, University of Health Sciences, Lahore, Pakistan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeenaf","family":"Aslam","sequence":"additional","affiliation":[{"name":"Institute of Nursing Sciences, Khyber Medical University, Peshawar, Pakistan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farhan","family":"Mukhtar","sequence":"additional","affiliation":[{"name":"University College of Nursing, The Islamia University of Bahawalpur, Bahawalpur, Pakistan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kokab","family":"Jabeen","sequence":"additional","affiliation":[{"name":"Department of Pathology, Ameer Ud Din Medical College, Lahore, Pakistan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahnoor","family":"Chaudhry","sequence":"additional","affiliation":[{"name":"Department of Pathology, Ameer Ud Din Medical College, Lahore, Pakistan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saeed Ur","family":"Rahman","sequence":"additional","affiliation":[{"name":"Department of Nursing, University of Health Sciences, Lahore, Pakistan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nasir","family":"Muhammad","sequence":"additional","affiliation":[{"name":"Department of Hematology, University of Health Sciences, Lahore, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"b1","series-title":"Med J Armed Forces India","first-page":"67","article-title":"Discovery of fifth serotype of dengue virus (DENV-5): a new public health dilemma in dengue control","volume":"71","author":"Mustafa","year":"2015"},{"key":"b2","series-title":"Can J Microbiol","first-page":"687","article-title":"Dengue virus: epidemiology, biology, and disease aetiology","volume":"67","author":"Roy","year":"2021"},{"key":"b3","series-title":"JMIR Public Health Surveill","first-page":"e27270","article-title":"Risk factors of dengue fever in urban 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