{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:40:59Z","timestamp":1791852059924,"version":"4.3.4"},"reference-count":53,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,1,3]]},"abstract":"<jats:title>ABSTRACT.<\/jats:title>\n                  <jats:p>\n                    The aims of this study were to estimate the prevalence of gastrointestinal manifestations among individuals with positive serology for Chagas disease (ChD) and to describe the clinical gastrointestinal manifestations of the disease. A systematic review with meta-analysis was conducted based on the criteria and recommendations of the Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines. The PubMed, Scopus, Virtual Health Library, Web of Science, and Embase databases were used to search for evidence. Two reviewers independently selected eligible articles and extracted data. RStudio\n                    <jats:sup>\u00ae<\/jats:sup>\n                    software was used for the meta-analysis. For subgroup analysis, the studies were divided according to the origin of the individuals included: 1) individuals from health units were included in the health care service prevalence analysis, and 2) individuals from the general population were included in the population prevalence analysis. A total of 2,570 articles were identified, but after removal of duplicates and application of inclusion criteria, 24 articles were included and 21 were part of the meta-analysis. Most of the studies were conducted in Brazil. Radiological diagnosis was the most frequent method used to identify the gastrointestinal clinical form. The combined effect of meta-analysis studies showed a prevalence of gastrointestinal manifestations in individuals with ChD of 12% (95% CI, 8.0\u201317.0%). In subgroup analysis, the prevalence for studies involving health care services was 16% (95% CI, 11.0\u201323.0%), while the prevalence for population-based studies was 9% (95% CI, 5.0\u201315.0%). Megaesophagus and megacolon were the main forms of ChD presentation in the gastrointestinal form. The prevalence of gastrointestinal manifestations of ChD was 12%. Knowing the prevalence of ChD in its gastrointestinal form is an important step in planning health actions for these patients.\n                  <\/jats:p>","DOI":"10.4269\/ajtmh.23-0323","type":"journal-article","created":{"date-parts":[[2023,12,5]],"date-time":"2023-12-05T12:05:11Z","timestamp":1701777911000},"page":"10-19","source":"Crossref","is-referenced-by-count":20,"title":["Gastrointestinal Manifestations of Chagas Disease: A Systematic Review with Meta-Analysis"],"prefix":"10.4269","volume":"110","author":[{"given":"Nayara Ragi","family":"Baldoni","sequence":"first","affiliation":[{"name":"University of Ita\u00fana, Ita\u00fana, Brazil;"},{"name":"Research Group in Epidemiology and Evaluation of New Technology in Health, UFSJ\/CNPq, Medical School, Federal University of de S\u00e3o Jo\u00e3o del-Rei, Divin\u00f3polis, Brazil;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lea Campos","family":"de Oliveira-da Silva","sequence":"additional","affiliation":[{"name":"Laboratory of Parasitology (LIM46), Clinical Hospital of S\u00e3o Paulo, Brazil;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Carolina Oliveira","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Research Group in Epidemiology and Evaluation of New Technology in Health, UFSJ\/CNPq, Medical School, Federal University of de S\u00e3o Jo\u00e3o del-Rei, Divin\u00f3polis, Brazil;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nayara Dornela","family":"Quintino","sequence":"additional","affiliation":[{"name":"Research Group in Epidemiology and Evaluation of New Technology in Health, UFSJ\/CNPq, Medical School, Federal University of de S\u00e3o Jo\u00e3o del-Rei, Divin\u00f3polis, Brazil;"},{"name":"Divin\u00f3polis Regional Health Superintendence\/Minas Gerais State Health Secretariat (SES-MG), Belo Horizonte, Brazil;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariela Mota","family":"Ferreira","sequence":"additional","affiliation":[{"name":"State University of Montes Claros (Unimontes), Montes Claro, Brazil;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Luiza","family":"Bierrenbach","sequence":"additional","affiliation":[{"name":"Teaching and Research Institute of S\u00edrio-Liban\u00eas Hospital, S\u00e3o Paulo, Brazil;"},{"name":"Graduate Program, Institute of Tropical Pathology and Public Health, Federal University of Goi\u00e1s, Goi\u00e2nia, Brazil;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Luiz","family":"Padilha da Silva","sequence":"additional","affiliation":[{"name":"Department of Statistics, Federal University of Paran\u00e1, Curitiba, Brazil;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Carmo","family":"Pereira Nunes","sequence":"additional","affiliation":[{"name":"Federal University of Minas Gerais, Belo Horizonte, Brazil;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio Luiz P.","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Federal University of Minas Gerais, Belo Horizonte, Brazil;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia Di Lorenzo","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Research Group in Epidemiology and Evaluation of New Technology in Health, UFSJ\/CNPq, Medical School, Federal University of de S\u00e3o Jo\u00e3o del-Rei, Divin\u00f3polis, Brazil;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ester Cerdeira","family":"Sabino","sequence":"additional","affiliation":[{"name":"Institute of Tropical Medicine, Faculty of Medicine, University of S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clareci Silva","family":"Cardoso","sequence":"additional","affiliation":[{"name":"Research Group in Epidemiology and Evaluation of New Technology in Health, UFSJ\/CNPq, Medical School, Federal University of de S\u00e3o Jo\u00e3o del-Rei, Divin\u00f3polis, Brazil;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"b1","series-title":"Lancet","first-page":"82","article-title":"Chagas disease","volume":"6","author":"P\u00e9rez-Molina","year":"2018"},{"key":"b2","series-title":"Am J Trop Med Hyg","first-page":"528","article-title":"Mortality due to Chagas disease in Brazil according to a specific cause","volume":"91","author":"N\u00f3brega","year":"2014"},{"key":"b3","series-title":"PLoS Negl Trop Dis","first-page":"e0010356","article-title":"Two-year death prediction models among patients with Chagas disease using machine learning-based methods","volume":"16","author":"Ferreira","year":"2022"},{"key":"b4","series-title":"Curr Probl Cardiol","first-page":"100507","article-title":"Chagas disease: chronic Chagas 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Estudo seccional em uma \u00e1rea end\u00eamica, Virgem da Lapa, Minas Gerais","volume":"19","author":"Pereira","year":"1986"},{"key":"b19","series-title":"Rev Soc Bras Med Trop","first-page":"101","article-title":"Morbidade da doen\u00e7a de chagas em popula\u00e7\u00f5es urbanas do Sert\u00e3o da Para\u00edba","volume":"20","author":"Pereira","year":"1987"},{"key":"b20","series-title":"Rev Soc Bras Med Trop","first-page":"13","article-title":"Preval\u00eancia de esofagopatia chag\u00e1sica no munic\u00edpio de Manba\u00ed, Goi\u00e1s, Brasil","volume":"20","author":"Castro","year":"1987"},{"key":"b21","series-title":"Rev Soc Bras Med Trop","first-page":"305","article-title":"O perfil dos portadores de doen\u00e7a de Chagas, com \u00eanfase na forma digestiva, em hospital terci\u00e1rio de Ribeir\u00e3o Preto, SP","volume":"38","author":"Kamiji","year":"2005"},{"key":"b22","series-title":"Rev Soc Bras Med Trop","first-page":"152","article-title":"Estudo radiol\u00f3gico do es\u00f4fago de chag\u00e1sicos, em 25 anos do Projeto Mamba\u00ed","volume":"39","author":"Pe\u00f1aranda-Carrillo","year":"2006"},{"key":"b23","series-title":"Cad Saude Publica","first-page":"1027","article-title":"Perfil cl\u00ednico-epidemiol\u00f3gico de pacientes com doen\u00e7a de Chagas no Hospital Universit\u00e1rio de Maring\u00e1, Paran\u00e1, Brasil","volume":"22","author":"Bozelli","year":"2006"},{"key":"b24","series-title":"Rev Soc Bras Med Trop","first-page":"311","article-title":"Apresenta\u00e7\u00e3o cl\u00ednica da doen\u00e7a de Chagas cr\u00f4nica em indiv\u00edduos idosos","volume":"40","author":"Almeida","year":"2007"},{"key":"b25","series-title":"Rev Soc Bras Med Trop","first-page":"622","article-title":"Chagas\u2019 disease and ageing: the coexistence of other chronic diseases with Chagas\u2019 disease in elderly patients","volume":"42","author":"Alves","year":"2009"},{"key":"b26","series-title":"Rev Soc Bras Med Trop","first-page":"562","article-title":"Estudo 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pharmaceutical care service in Cear\u00e1 State, Northeastern Brazil","volume":"57","author":"Pereira","year":"2015"},{"key":"b31","series-title":"Rev Soc Bras Med Trop","first-page":"706","article-title":"Chagas disease: morbidity profile in an endemic area of Northeastern Brazil","volume":"48","author":"Andrade","year":"2015"},{"key":"b32","series-title":"Pathog Glob Health","first-page":"228","article-title":"The detection of Trypanosoma cruzi by nested-PCR in elderly patients: relationship to the clinical and epidemiological profile","volume":"110","author":"Pereira","year":"2016"},{"key":"b33","series-title":"Rev Soc Bras Med Trop","first-page":"225","article-title":"Epidemiological and clinical profile of patients with Chagas disease in the Central-North area of Paran\u00e1, Southern Brazil","volume":"51","author":"Gasparim","year":"2018"},{"key":"b34","series-title":"Rev Inst Med Trop S\u00e3o Paulo","first-page":"e7","article-title":"Increased serum gastrin in patients with different clinical forms of Chagas disease coinfected with Helicobacter pylori","volume":"61","author":"Sousa","year":"2019"},{"key":"b35","series-title":"Rev Bras Clin Med","first-page":"325","article-title":"Depress\u00e3o e doen\u00e7a de Chagas","volume":"9","author":"Marchi","year":"2011"},{"key":"b36","series-title":"Mem Inst Oswaldo Cruz","first-page":"733","article-title":"Clinical forms of Trypanosoma cruzi infected individuals in the chronic phase of Chagas disease in Puebla, Mexico","volume":"101","author":"S\u00e1nchez-Guill\u00e9n","year":"2006"},{"key":"b37","series-title":"PLoS Negl Trop Dis","first-page":"e3105","article-title":"Characterization of digestive involvement in patients with chronic T. cruzi infection in Barcelona, Spain","volume":"8","author":"Pinazo","year":"2014"},{"key":"b38","series-title":"Lancet","first-page":"1388","article-title":"Chagas disease","volume":"375","author":"Rassi","year":"2010"},{"key":"b39","series-title":"Am J 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