{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T14:07:53Z","timestamp":1780668473440,"version":"3.54.1"},"reference-count":20,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,4,3]]},"abstract":"<jats:title>ABSTRACT.<\/jats:title>\n<jats:p>Unlike praziquantel, artemisinin derivatives are effective against juvenile schistosome worms. We assessed the efficacy and safety of a single oral dose of artesunate plus sulfalene-pyrimethamine versus praziquantel in the treatment of <jats:italic>Schistosoma mansoni.<\/jats:italic> Seventy-three schoolchildren (aged 9\u201315\u2009years) with confirmed <jats:italic>S. mansoni<\/jats:italic> infection in Rarieda, western Kenya, were randomly assigned to receive either a single oral dose of artesunate plus sulfalene-pyrimethamine (<jats:italic>n<\/jats:italic> = 39) or a single dose of praziquantel (<jats:italic>n<\/jats:italic> = 34). The cure and egg reduction rates at 4\u2009weeks posttreatment were 69.4% (25\/36) versus 80.6% (25\/31) (<jats:italic>P<\/jats:italic> = 0.297) and 99.1% versus 97.5% (<jats:italic>P<\/jats:italic> = 0.607) in the artesunate plus sulfalene-pyrimethamine group versus praziquantel group, respectively. Fourteen children developed adverse events, and there were no serious adverse events. A single oral dose of artesunate plus sulfalene-pyrimethamine has efficacy comparable to that of praziquantel in the treatment of <jats:italic>S. mansoni<\/jats:italic>, but these results should be confirmed in larger randomized controlled trials.<\/jats:p>","DOI":"10.4269\/ajtmh.23-0337","type":"journal-article","created":{"date-parts":[[2024,3,8]],"date-time":"2024-03-08T21:47:54Z","timestamp":1709934474000},"page":"677-680","source":"Crossref","is-referenced-by-count":4,"title":["Efficacy of a Single Oral Dose of Artesunate plus Sulfalene-Pyrimethamineversus Praziquantel in the Treatment of Schistosoma mansoni in Kenyan Children: An Open-Label, Randomized, Exploratory Trial"],"prefix":"10.4269","volume":"110","author":[{"given":"Erick M. O.","family":"Muok","sequence":"first","affiliation":[{"name":"Centre for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent O.","family":"Were","sequence":"additional","affiliation":[{"name":"Centre for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles O.","family":"Obonyo","sequence":"additional","affiliation":[{"name":"Centre for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"b1","series-title":"Lancet Infect Dis","first-page":"927","article-title":"Spatial distribution of schistosomiasis and treatment needs in sub-Saharan Africa: A systematic review and geostatistical analysis","volume":"15","author":"Lai","year":"2015"},{"key":"b2","series-title":"Wkly Epidemiol 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trials","volume":"8","author":"Zwang","year":"2014"},{"key":"b16","series-title":"Am J Trop Med Hyg","first-page":"167","article-title":"Efficacy and side effects of praziquantel in an epidemic focus of Schistosoma mansoni.","volume":"53","author":"Stelma","year":"1995"},{"key":"b17","series-title":"PLoS One","first-page":"e6732","article-title":"Efficacy of artesunate + sulfamethoxypyrazine\/pyrimethamine versus praziquantel in the treatment of Schistosoma haematobium in children","volume":"4","author":"Sissoko","year":"2009"},{"key":"b18","series-title":"Trans R Soc Trop Med Hyg","first-page":"1062","article-title":"Artesunate plus sulfadoxine\/pyrimethamine versus praziquantel in the treatment of Schistosoma mansoni in eastern Sudan","volume":"103","author":"Mohamed","year":"2009"},{"key":"b19","series-title":"PLoS Negl Trop Dis","first-page":"e3234","article-title":"Impact of Schistosoma mansoni on malaria transmission in Sub-Saharan Africa","volume":"8","author":"Ndeffo Mbah","year":"2014"},{"key":"b20","series-title":"PLoS Negl Trop Dis","first-page":"e0005193","article-title":"Plasmodium falciparum infection status among children with Schistosoma in Sub-Saharan Africa: A systematic review and meta-analysis","volume":"10","author":"Degarege","year":"2016"}],"container-title":["The American Journal of Tropical Medicine and 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