{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T13:35:38Z","timestamp":1751376938283},"reference-count":12,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"6","license":[{"start":{"date-parts":[[2023,12,6]],"date-time":"2023-12-06T00:00:00Z","timestamp":1701820800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,12,6]]},"abstract":"<jats:title>ABSTRACT.<\/jats:title>\n<jats:p>Several studies in tropical settings have reported that \u223c20% of patients infected with Monkeypox virus (MPXV) also tested polymerase chain reaction (PCR) positive for Varicella zoster virus (VZV). Researchers have hypothesized that VZV infection predisposes to monkeypox (mpox), or vice versa, or that MPXV triggers the reactivation of VZV. We tested samples for VZV from a cohort of patients infected with clade IIb MPXV diagnosed between May 23 and October 14, 2022 in Antwerp, Belgium. Leftover DNA extracts of skin lesion samples from 108 mpox patients were tested with in-house PCR for VZV. No VZV infections were found. The absence of concurrent VZV-MPXV infections in our cohort indicates that VZV did not cocirculate in the population at risk for MPXV during the Belgian 2022 outbreak, but also that MPXV does not commonly trigger reactivation of latent VZV in adult men.<\/jats:p>","DOI":"10.4269\/ajtmh.23-0353","type":"journal-article","created":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T16:29:19Z","timestamp":1697473759000},"page":"1282-1283","source":"Crossref","is-referenced-by-count":2,"title":["No Varicella Zoster Virus Infection among Mpox Cases in Antwerp, Belgium"],"prefix":"10.4269","volume":"109","author":[{"given":"Jasmine","family":"Coppens","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurens","family":"Liesenborghs","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koen","family":"Vercauteren","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marjan","family":"Van Esbroeck","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christophe","family":"Van Dijck","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Institute of Tropical Medicine, Antwerp, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2795","reference":[{"key":"b1","series-title":"Lancet","first-page":"60","article-title":"Monkeypox","volume":"401","author":"Mitj\u00e0","year":"2023"},{"key":"b2","series-title":"PLoS One","first-page":"e96930","article-title":"Simple technique for in field samples collection in the cases of skin rash illness and subsequent PCR detection of orthopoxviruses and varicella zoster virus","volume":"9","author":"Dumont","year":"2014"},{"key":"b3","series-title":"BMC Infect Dis","first-page":"717","article-title":"Varicella zoster virus-associated morbidity and mortality in Africa: a systematic review","volume":"17","author":"Hussey","year":"2017"},{"key":"b4","series-title":"Viruses","first-page":"2800","article-title":"Reassessment of evidence about coinfection of chickenpox and monkeypox (mpox) in African children","volume":"14","author":"Khallafallah","year":"2022"},{"key":"b5","series-title":"EcoHealth","first-page":"564","article-title":"Varicella coinfection in patients with active monkeypox in the Democratic Republic of the Congo","volume":"14","author":"Hoff","year":"2017"},{"key":"b6","series-title":"Am J Trop Med Hyg","first-page":"604","article-title":"A tale of two viruses: coinfections of monkeypox and varicella zoster virus in the Democratic Republic of Congo","volume":"104","author":"Hughes","year":"2021"},{"key":"b7","series-title":"Front Public Health","first-page":"1066589","article-title":"The epidemiological trend of monkeypox and monkeypox-varicella zoster viruses co-infection in North-Eastern Nigeria","volume":"10","author":"Stephen","year":"2022"},{"key":"b8","series-title":"Travel Med Infect Dis","first-page":"102510","article-title":"First reports of monkeypox and varicella-zoster virus coinfection in the global human monkeypox outbreak in 2022","volume":"51","author":"Martins-Filho","year":"2023"},{"key":"b9","series-title":"Front Public Health","first-page":"1140956","article-title":"Surveillance of Nigerian children suggests that varicella may be a risk factor for acquisition of monkeypox","volume":"11","author":"Grose","year":"2023"},{"key":"b10","series-title":"J Virol Methods","first-page":"215","article-title":"Species-specific differentiation of variola, monkeypox, and varicella-zoster viruses by multiplex real-time PCR assay","volume":"236","author":"Maksyutov","year":"2016"},{"key":"b11","series-title":"Arch Dis Child","first-page":"16","article-title":"Varicella paediatric hospitalisations in Belgium: a 1-year national survey","volume":"101","author":"Blumental","year":"2016"},{"key":"b12","series-title":"Occup Environ Med","first-page":"621","article-title":"Occupational risk of infection by varicella zoster virus in Belgian healthcare workers: a seroprevalence study","volume":"57","author":"Vandersmissen","year":"2000"}],"container-title":["The American Journal of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/109\/6\/article-p1282.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/109\/6\/article-p1282.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/109\/6\/article-p1282.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,6]],"date-time":"2023-12-06T15:45:52Z","timestamp":1701877552000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/109\/6\/article-p1282.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,6]]},"references-count":12,"journal-issue":{"issue":"6"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.23-0353","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"value":"0002-9637","type":"print"},{"value":"1476-1645","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,6]]}}}