{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T21:46:45Z","timestamp":1764020805253},"reference-count":22,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,8,7]]},"abstract":"<jats:title>ABSTRACT.<\/jats:title>\n<jats:p>Increasing sulfadoxine-pyrimethamine (SP) resistance in the Democratic Republic of the Congo (DRC) has threatened its use for prevention of malaria in one of the most malarious countries in the world. Using geographic information on mining operations in the DRC and genetic data on SP drug resistance markers from the 2013\u20132014 Demographic and Health Surveys, we evaluated associations between close residence to mining and the presence of mutations conferring resistance to sulfadoxine. Close residential proximity to mining was associated with increased prevalence odds ratio (POR) of the <jats:italic>dhps<\/jats:italic>540E mutation (POR: 2.11, 95% uncertainty interval: 1.15\u20133.96) with adjustments for confounding variables and space. Our findings indicate that exposure to mining is associated with increased presence of an antimalarial drug resistance haplotype that threatens effective use of SP for vulnerable populations. Areas actively engaged in mining could be considered for interventions to reduce the spread of emerging drug resistance in the DRC.<\/jats:p>","DOI":"10.4269\/ajtmh.23-0355","type":"journal-article","created":{"date-parts":[[2024,6,11]],"date-time":"2024-06-11T17:42:39Z","timestamp":1718127759000},"page":"361-364","source":"Crossref","is-referenced-by-count":1,"title":["Close Proximity to Mining Is Associated with Increased Prevalence of the Drug Resistance\u2013Associated Mutation dhps540E in Eastern Democratic Republic of the Congo"],"prefix":"10.4269","volume":"111","author":[{"given":"Cedar L.","family":"Mitchell","sequence":"first","affiliation":[{"name":"Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark M.","family":"Janko","sequence":"additional","affiliation":[{"name":"Duke Global Health Institute, Duke University, Durham, North Carolina;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Verity","sequence":"additional","affiliation":[{"name":"Medical Research Council Centre for Global Infectious Disease Analysis, Department of Infectious Disease Epidemiology, Imperial College London, London, United Kingdom;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melchior M.","family":"Kashamuka","sequence":"additional","affiliation":[{"name":"Kinshasa School of Public Health, Kinshasa University, Kinshasa, Democratic Republic of the Congo;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey A.","family":"Bailey","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Warren Alpert Medical School, Brown University, Providence, Rhode Island;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antoinette K.","family":"Tshefu","sequence":"additional","affiliation":[{"name":"Kinshasa School of Public Health, Kinshasa University, Kinshasa, Democratic Republic of the Congo;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan B.","family":"Parr","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, University of North Carolina School of Medicine, Chapel Hill, North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan J.","family":"Juliano","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina;"},{"name":"Division of Infectious Diseases, University of North Carolina School of Medicine, Chapel Hill, North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2795","reference":[{"key":"b1","series-title":"Sci Rep","first-page":"1","article-title":"Mapping sulphadoxine-pyrimethamine-resistant Plasmodium falciparum malaria in infected humans and in parasite populations in 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