{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T12:28:48Z","timestamp":1788956928447,"version":"build-2803163510"},"reference-count":43,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,3,6]]},"abstract":"<jats:title>ABSTRACT.<\/jats:title>\n<jats:p>The Indonesian government has provided iron\u2013folic acid (IFA) supplementation in response to maternal pregnancy iron-deficiency anemia. However, community-based cohorts on IFA\u2019s effects on maternal and infant anemia are limited. A mixed-method study design with a primary longitudinal cohort was used to observe the association between IFA and anemia in mothers and infants. Iron\u2013folic acid supplementation was observed throughout pregnancy. Anemia status was based on a single hemoglobin assessment using HemoCue Hb 201 + in the second or third trimester of pregnancy for the mother and at birth for the infant. Qualitative data were collected via in-depth interviews (IDIs) and a forum group discussion (FGD). Iron\u2013folic acid supplementation with &gt;\u00a0180 tablets throughout pregnancy was associated with lower pregnancy anemia (adjusted relative risk [aRR] = 0.25, 95% CI: 0.092\u20130.664, <jats:italic>P<\/jats:italic> = 0.006) after adjusting for potential confounding variables. Supplementation with IFA was not associated with infant anemia (RR = 1.033, 95% CI: 0.70\u20131.54, <jats:italic>P<\/jats:italic> = 0.873 for 90\u2013180 tablets and RR = 1.07, 95% CI 0.70\u20131.63, <jats:italic>P<\/jats:italic> = 0.774 for &gt;\u00a0180 tablets). The IDIs and FGD suggested that IFA and multivitamin content knowledge, IFA consumption monitoring, and paternal involvement were important in IFA supplementation and effectiveness in reducing anemia. Iron\u2013folic acid supplementation was associated with reduced maternal but not infant anemia. Because maternal anemia is associated with infant anemia, an anemia monitoring program for women in early pregnancy is vital in addressing infant health. Paternal involvement was also identified as a major factor in maternal and child health.<\/jats:p>","DOI":"10.4269\/ajtmh.23-0411","type":"journal-article","created":{"date-parts":[[2024,2,13]],"date-time":"2024-02-13T20:51:27Z","timestamp":1707857487000},"page":"576-587","source":"Crossref","is-referenced-by-count":9,"title":["Association between Iron\u2013Folic Acid Supplementation during Pregnancy and Maternal and Infant Anemia in West Java, Indonesia: A Mixed-Method Prospective Cohort Study"],"prefix":"10.4269","volume":"110","author":[{"given":"Ratu Ayu Dewi","family":"Sartika","sequence":"first","affiliation":[{"name":"Department of Public Health Nutrition, Faculty of Public Health, Universitas Indonesia, Depok, Indonesia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fadila","family":"Wirawan","sequence":"additional","affiliation":[{"name":"Department of Public Health Nutrition, Faculty of Public Health, Universitas Indonesia, Depok, Indonesia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Primasti Nuryandari","family":"Putri","sequence":"additional","affiliation":[{"name":"Department of Public Health Nutrition, Faculty of Public Health, Universitas Indonesia, Depok, Indonesia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nurul Husna","family":"Mohd Shukri","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Kuala Lumpur, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"b1","series-title":"Cureus","first-page":"e30083","article-title":"Importance of maternal nutrition in the first 1,000 days of life and its effects on child development: a narrative review","volume":"14","author":"Likhar","year":"2022"},{"key":"b2","series-title":"Am J Clin Nutr","first-page":"414","article-title":"The double burden of malnutrition among adolescents: analysis of data from the Global School-Based Student Health and Health Behavior in School-Aged Children surveys in 57 low- and middle-income countries","volume":"108","author":"Caleyachetty","year":"2018"},{"key":"b3","year":"2018"},{"key":"b4","series-title":"J Family Community Med","first-page":"118","article-title":"Effect of maternal anemia on the status of iron stores in infants: a cohort study","volume":"26","author":"Shukla","year":"2019"},{"key":"b5","series-title":"Nutrients","first-page":"2221","article-title":"Maternal iron status in pregnancy and child health outcomes after birth: a systematic review and meta-analysis","volume":"13","author":"Quezada-Pinedo","year":"2021"},{"key":"b6","series-title":"Epidemiol Health","first-page":"e2022100","article-title":"Maternal pre-pregnancy anemia and childhood anemia in Indonesia: a risk assessment using a population-based prospective longitudinal study","volume":"44","author":"Wirawan","year":"2022"},{"key":"b7","series-title":"Anemia","first-page":"6636043","article-title":"Anemia and contributing factors in severely malnourished infants and children aged between 0 and 59 months admitted to the treatment centers of the Amhara region, Ethiopia: a multicenter chart review study","volume":"2021","author":"Takele","year":"2021"},{"key":"b8","series-title":"PLoS One","first-page":"e0214563","article-title":"Very severe anemia and one year mortality outcome after hospitalization in Tanzanian children: a prospective cohort study","volume":"14","author":"Chami","year":"2019"},{"key":"b9","series-title":"Iron Deficiency Anemia","author":"Warner","year":"2022"},{"key":"b10","series-title":"Folic Acid","author":"Merrell","year":"2023"},{"key":"b11","series-title":"WHO Antenatal Care Recommendations for a Positive Pregnancy Experience. Nutritional Interventions Update: Multiple Micronutrient Supplements During Pregnancy","year":"2020"},{"key":"b12","series-title":"Nutrients","first-page":"2632","article-title":"Antenatal iron-folic acid supplementation is associated with improved linear growth and reduced risk of stunting or severe stunting in South Asian children less than two years of age: a pooled analysis from seven countries","volume":"12","author":"Nisar","year":"2020"},{"key":"b13","series-title":"PLoS One","first-page":"e0167416","article-title":"Impact of preconception micronutrient supplementation on anemia and iron status during pregnancy and postpartum: a randomized controlled trial in rural Vietnam","volume":"11","author":"Nguyen","year":"2016"},{"key":"b14","series-title":"Matern Child Nutr","first-page":"e12895","article-title":"Maternal folic acid supplementation and infant birthweight in low- and middle-income countries: a systematic review","volume":"16","author":"Jonker","year":"2020"},{"key":"b15","series-title":"Int J Prev Med","first-page":"18","article-title":"The impact of iron supplementation during pregnancy and change of consumption among stunting children aged 6-24 months during the COVID-19 pandemic in Indonesia","volume":"14","author":"Sari","year":"2023"},{"key":"b16","year":"2021"},{"key":"b17","series-title":"Guidelines for Administering Blood Supplement Tablets (IFAs) for Pregnant Women during the COVID-19 Pandemic for Health Workers","year":"2020"},{"key":"b18","year":"2016"},{"key":"b19","series-title":"Nutrients","first-page":"3114","article-title":"Iron and folic acid supplementation in pregnancy: findings from the baseline assessment of a maternal nutrition service programme in Bangladesh","volume":"14","author":"Billah","year":"2022"},{"key":"b20","series-title":"Iron Deficiency Anaemia Assessment Prevention and Control: A Guide for Programme Managers","year":"2001"},{"key":"b21","series-title":"Mosby\u2019s Diagnostic & Laboratory Test Reference","author":"Pagana","year":"2019"},{"key":"b22","year":"2011"},{"key":"b23","series-title":"Beitr Infusionsther","first-page":"235","article-title":"The critical hemoglobin value in newborn infants, infants and children [in German]","volume":"30","author":"Linderkamp","year":"1992"},{"key":"b24","series-title":"Antenatal Care Guide","year":"2020"},{"key":"b25","series-title":"Guidelines for Tackling Chronic Energy Malnutrition in Pregnant Women","year":"2015"},{"key":"b26","series-title":"Ethiop J Health Sci","first-page":"153","article-title":"Maternal height as an independent risk factor for neonatal size among adolescent Bengalees in Kolkata, India","volume":"20","author":"Bisai","year":"2010"},{"key":"b27","series-title":"Body Mass Index Limit for Indonesia","year":"2019"},{"key":"b28","series-title":"Indonesian Food Composition Table","year":"2017"},{"key":"b29","series-title":"National Food and Nutrition Widyakarya X: Presentation and Poster","year":"2012"},{"key":"b30","series-title":"Front Nutr","first-page":"1030343","article-title":"Nutrient intakes of pregnant and lactating women in Indonesia and Malaysia: systematic review and meta-analysis","volume":"10","author":"Agustina","year":"2023"},{"key":"b31","series-title":"Sari Pediatr 22.","article-title":"Prevalence of anemia in newborns according to birth weight and gestational age at RSUP Dr. Hasan Sadikin Bandung in 2018","author":"Asfarina","year":"2020"},{"key":"b32","series-title":"Iron Metabolism","first-page":"299","author":"Bern\u00e1t","year":"1983"},{"key":"b33","series-title":"Clin Nutr ESPEN","first-page":"e1","article-title":"Role of nutrition on anemia in elderly","volume":"11","author":"Bianchi","year":"2016"},{"key":"b34","series-title":"Front Nutr","first-page":"847693","article-title":"The prevalence and risk factors of iron deficiency anemia among pregnant women in Malaysia: a systematic review","volume":"9","author":"Abd Rahman","year":"2022"},{"key":"b35","series-title":"Food Nutr Bull","first-page":"S92","article-title":"Associations of knowledge, attitude, and practices toward anemia with anemia prevalence and height-for-age Z-score among Indonesian adolescent girls","volume":"42","author":"Agustina","year":"2021"},{"key":"b36","series-title":"Maternal and Child Health Book","year":"2020"},{"key":"b37","series-title":"Saudi Med J","first-page":"146","article-title":"The impact of maternal iron deficiency and iron deficiency anemia on child\u2019s health","volume":"36","author":"Abu-Ouf","year":"2015"},{"key":"b38","series-title":"Indonesian J Med Health","first-page":"276","article-title":"Supplementation and fortification program in eradicating micronutrient deficiencies in Indonesia","volume":"12","author":"Octavia","year":"2021"},{"key":"b39","series-title":"Survey of Indonesia\u2019s Nutritional Status","year":"2022"},{"key":"b40","series-title":"Am J Obstet Gynecol","first-page":"103","article-title":"Paternal factors and low birthweight, preterm, and small for gestational age births: a systematic review","volume":"202","author":"Shah","year":"2010"},{"key":"b41","series-title":"BMC Pregnancy Childbirth","first-page":"19","article-title":"Paternal factors and adverse birth outcomes in Lanzhou, China","volume":"21","author":"Li","year":"2021"},{"key":"b42","series-title":"Matern Child Health J","first-page":"735","article-title":"The impact of paternal involvement on feto-infant morbidity among Whites, Blacks and Hispanics","volume":"14","author":"Alio","year":"2010"},{"key":"b43","series-title":"BMC Womens Health","first-page":"220","article-title":"Reassessing the level and implications of male involvement in family planning in Indonesia","volume":"23","author":"Rahayu","year":"2023"}],"container-title":["The American Journal of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/110\/3\/article-p576.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/110\/3\/article-p576.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/110\/3\/article-p576.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,6]],"date-time":"2024-03-06T13:56:15Z","timestamp":1709733375000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/110\/3\/article-p576.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,6]]},"references-count":43,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.23-0411","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"value":"0002-9637","type":"print"},{"value":"1476-1645","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,6]]}}}