{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,12,7]],"date-time":"2023-12-07T00:44:17Z","timestamp":1701909857492},"reference-count":68,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,12,6]]},"abstract":"<jats:title>ABSTRACT.<\/jats:title>\n<jats:p>Hepatosplenic schistosomiasis (HSS) is a serious complication of chronic schistosomiasis that can result in portal hypertension and variceal bleeding. \u03b2-blockers, a class of medications commonly used to treat hypertension and other cardiovascular conditions, have been investigated for their potential use in preventing variceal bleeding in HSS. Several studies have shown that \u03b2-blockers can reduce portal pressure and prevent variceal bleeding effectively in these patients. However, there are limited data on the long-term efficacy and safety of \u03b2-blockers in this setting, and further research is needed to determine the optimal use of these medications. This review summarizes the evidence supporting current recommendations of \u03b2-blocker use in patients with HSS.<\/jats:p>","DOI":"10.4269\/ajtmh.23-0437","type":"journal-article","created":{"date-parts":[[2023,11,6]],"date-time":"2023-11-06T18:57:28Z","timestamp":1699297048000},"page":"1213-1219","source":"Crossref","is-referenced-by-count":0,"title":["\u03b2-Blockers in Hepatosplenic Schistosomiasis: A Narrative Review"],"prefix":"10.4269","volume":"109","author":[{"given":"Fernanda Alves","family":"Gelape","sequence":"first","affiliation":[{"name":"Faculdade de Ci\u00eancias M\u00e9dicas de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia Alves","family":"Couto","sequence":"additional","affiliation":[{"name":"Hospital das Cl\u00ednicas da Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guilherme Grossi Lopes","family":"Can\u00e7ado","sequence":"additional","affiliation":[{"name":"Hospital das Cl\u00ednicas da Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil;"},{"name":"Hospital da Pol\u00edcia Militar de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2795","reference":[{"key":"b1","year":"2021"},{"key":"b2","year":"2013"},{"key":"b3","year":"2019"},{"key":"b4","series-title":"PLoS Negl Trop Dis","first-page":"e0010575","article-title":"Reduction in DALYs lost due to soil-transmitted helminthiases and schistosomiasis from 2000 to 2019 is parallel to the increase in coverage of the global control programmes","volume":"16","author":"Montresor","year":"2022"},{"key":"b5","series-title":"Trop Med Infect Dis","first-page":"20","article-title":"Morbidity and mortality due to Schistosoma mansoni related periportal fibrosis: could early diagnosis of varices improve the outcome following available treatment modalities in sub Saharan Africa? 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