{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T11:13:44Z","timestamp":1780917224544,"version":"3.54.1"},"reference-count":37,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"1","license":[{"start":{"date-parts":[[2024,7,3]],"date-time":"2024-07-03T00:00:00Z","timestamp":1719964800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,7,3]]},"abstract":"<jats:title>ABSTRACT.<\/jats:title>\n<jats:p>In countries where soil-transmitted helminth (STH) infections are endemic, deworming programs are recommended to reduce morbidity; however, increasing levels of resistance to benzimidazoles are of concern. In an observational study in Peru, we studied the clinical efficacy of 400\u2009mg of albendazole 20\u2009days after treatment among children aged 2\u201311\u2009years. Of 426 participants who provided samples, 52.3% were infected with a STH, 144 (33.8%) were positive for <jats:italic>Ascaris<\/jats:italic> (41.8% light, 50.8% moderate, and 7.4% heavy infections), 147 (34.5%) were positive for <jats:italic>Trichuris<\/jats:italic> (75.2% light, 22.5% moderate, and 2.3% heavy infections), and 1.1% were positive for hookworm species (100% light infections). Additional stool samples were examined at 20, 90, and 130\u2009days after the initial treatment. At 20\u2009days post-administration of albendazole, the cure rate (CR) of <jats:italic>Ascaris<\/jats:italic> infection was 80.1% (95% CI: 73.5\u201386.7), and the egg reduction rate (ERR) was 70.8% (95% CI: 57.8\u201388.7); the CR for <jats:italic>Trichuris<\/jats:italic> infection was 27.1% (95% CI: 20.0\u201334.3), and the ERR was 29.8% (95% CI: \u20131.40 to 57.5). Among participants with persistent or recurrent infections with <jats:italic>Trichuris<\/jats:italic>, the combined therapy of albendazole (400\u2009mg) and ivermectin at 600\u2009<jats:italic>\u00b5<\/jats:italic>g\/dose increased overall CR for <jats:italic>Trichuris<\/jats:italic> infection to 75.2% (95% CI: 67.3\u201383.2%) with an ERR of 84.2% (95% CI: 61.3\u201393.8%). Albendazole administration alone for the control of STH was associated with high rates of treatment failure, especially for <jats:italic>Trichuris<\/jats:italic>. Combined single doses of albendazole and ivermectin was observed to have improved efficacy.<\/jats:p>","DOI":"10.4269\/ajtmh.23-0497","type":"journal-article","created":{"date-parts":[[2024,5,28]],"date-time":"2024-05-28T18:11:00Z","timestamp":1716919860000},"page":"80-88","source":"Crossref","is-referenced-by-count":4,"title":["Efficacy of Single-Dose Albendazole and Albendazole Plus Ivermectin for Soil-Transmitted Helminth Infection in Children in the Peruvian Amazon"],"prefix":"10.4269","volume":"111","author":[{"given":"Greisi","family":"Curico","sequence":"first","affiliation":[{"name":"Asociaci\u00f3n Ben\u00e9fica PRISMA, Iquitos, Peru;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul F.","family":"Garcia Bardales","sequence":"additional","affiliation":[{"name":"Asociaci\u00f3n Ben\u00e9fica PRISMA, Iquitos, Peru;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tackeshy N.","family":"Pinedo Vasquez","sequence":"additional","affiliation":[{"name":"Asociaci\u00f3n Ben\u00e9fica PRISMA, Iquitos, Peru;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wagner Valentino","family":"Shapiama Lopez","sequence":"additional","affiliation":[{"name":"Asociaci\u00f3n Ben\u00e9fica PRISMA, Iquitos, Peru;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maribel","family":"Paredes Olortegui","sequence":"additional","affiliation":[{"name":"Asociaci\u00f3n Ben\u00e9fica PRISMA, Iquitos, Peru;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Schiaffino","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine, Universidad Peruana Cayetano Heredia, Lima, Peru;"},{"name":"Division of Infectious Disease and International Health, University of Virginia, Charlottesville, Virginia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Pe\u00f1ataro Yori","sequence":"additional","affiliation":[{"name":"Division of Infectious Disease and International Health, University of Virginia, Charlottesville, Virginia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josh M.","family":"Colston","sequence":"additional","affiliation":[{"name":"Division of Infectious Disease and International Health, University of Virginia, Charlottesville, Virginia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas G.","family":"Flynn","sequence":"additional","affiliation":[{"name":"Division of Infectious Disease and International Health, University of Virginia, Charlottesville, Virginia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graciela","family":"Meza S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Universidad Nacional de la Amazonia Peruana, Iquitos, Peru;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hermann","family":"Silva Delgado","sequence":"additional","affiliation":[{"name":"Universidad Nacional de la Amazonia Peruana, Iquitos, Peru;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard A.","family":"Oberhelman","sequence":"additional","affiliation":[{"name":"Tulane University, New Orleans, Louisiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret N.","family":"Kosek","sequence":"additional","affiliation":[{"name":"Division of Infectious Disease and International Health, University of Virginia, Charlottesville, Virginia;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"b1","series-title":"PLoS Negl Trop Dis","first-page":"e0009561","article-title":"Long-term outcomes of ivermectin-albendazole versus albendazole alone against soil-transmitted helminths: Results from randomized controlled trials in Lao PDR and Pemba Island, 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