{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,5]],"date-time":"2024-09-05T00:29:25Z","timestamp":1725496165379},"reference-count":11,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,9,4]]},"abstract":"<jats:title>ABSTRACT.<\/jats:title>\n<jats:p>This case report presents an atypical manifestation of tuberculosis in a 21-year-old male who presented with multiple subcutaneous swellings in the bilateral heel, left elbow, and base of the left third finger for the previous 6 months. The patient also experienced loss of appetite and unintentional weight loss. Despite initial suspicion of bacterial abscesses, antibiotics did not lead to significant improvement. Further investigations revealed an elevated erythrocyte sedimentation rate and findings suggestive of osteomyelitis on imaging. Gene Xpert testing confirmed multidrug-resistant <jats:italic>Mycobacterium tuberculosis<\/jats:italic> as the causative agent. The patient was prescribed a bedaquiline-based multidrug-resistant tuberculosis regimen, which resulted in reduction in swelling size. This report highlights the challenges in diagnosing and managing complex cases of primary multiple tubercular abscesses, especially with drug-resistant strains, emphasizing the importance of timely diagnosis and multidisciplinary management for successful outcomes.<\/jats:p>","DOI":"10.4269\/ajtmh.23-0514","type":"journal-article","created":{"date-parts":[[2024,7,9]],"date-time":"2024-07-09T13:37:14Z","timestamp":1720532234000},"page":"526-528","source":"Crossref","is-referenced-by-count":0,"title":["Case Report: Multiple Metastatic Primary Multidrug-Resistant Tubercular Abscesses"],"prefix":"10.4269","volume":"111","author":[{"given":"Megha","family":"Priyadarshi","sequence":"first","affiliation":[{"name":"Department of Medicine, All India Institute of Medical Sciences, New Delhi, India;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harish","family":"Pant","sequence":"additional","affiliation":[{"name":"Department of Medicine, All India Institute of Medical Sciences, New Delhi, India;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sunit","family":"Sikdar","sequence":"additional","affiliation":[{"name":"Department of Medicine, All India Institute of Medical Sciences, New Delhi, India;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanjeev","family":"Sinha","sequence":"additional","affiliation":[{"name":"Department of Medicine, All India Institute of Medical Sciences, New Delhi, India;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Surabhi","family":"Vyas","sequence":"additional","affiliation":[{"name":"Department of Radiodiagnosis and Interventional Radiology, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piyush","family":"Ranjan","sequence":"additional","affiliation":[{"name":"Department of Medicine, All India Institute of Medical Sciences, New Delhi, India;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2795","reference":[{"year":"2022","series-title":"Global Tuberculosis Report 2022","key":"b1"},{"key":"b2","series-title":"Lancet Microbe","first-page":"e20","article-title":"WHO\u2019s Global Tuberculosis Report 2022","volume":"4","author":"Bagcchi","year":"2023"},{"key":"b3","series-title":"J Respir.","first-page":"141","article-title":"Extrapulmonary tuberculosis\u2014An update on the diagnosis, treatment and drug resistance","volume":"1","author":"Gopalaswamy","year":"2021"},{"key":"b4","series-title":"Respirology","first-page":"596","article-title":"Challenges to the global control of tuberculosis","volume":"18","author":"Chiang","year":"2013"},{"key":"b5","series-title":"J Family Med Prim Care","first-page":"84","article-title":"Status of drug resistant tuberculosis among patients attending a tuberculosis unit of West Bengal: A record based cross-sectional study","volume":"11","author":"Dutt","year":"2022"},{"key":"b6","series-title":"Front Neurol","first-page":"1031","article-title":"Muscular tuberculosis: A new case and a review of the literature","volume":"10","author":"Zeng","year":"2019"},{"key":"b7","series-title":"BMC Infect Dis","first-page":"409","article-title":"Multiple subcutaneous tuberculous abscesses in a dermatomyositis patient without pulmonary tuberculosis: A case report and literature review","volume":"20","author":"Gao","year":"2020"},{"key":"b8","series-title":"Saudi J Kidney Dis Transpl","first-page":"1175","article-title":"An unusual clinical presentation of tuberculous pyomyositis in a renal allograft recipient","volume":"30","author":"Khandalvalli","year":"2019"},{"key":"b9","series-title":"Clin Exp Rheumatol","first-page":"734","article-title":"Tuberculous pyomyositis in a rheumatoid arthritis patient treated with anakinra","volume":"33","author":"Migkos","year":"2015"},{"key":"b10","series-title":"Case Rep Infect Dis","first-page":"723879","article-title":"Primary tuberculous pyomyositis of quadriceps femoris in an immunocompetent individual","volume":"2013","author":"Modi","year":"2013"},{"key":"b11","series-title":"Scand J Infect Dis","first-page":"37","article-title":"Tuberculous subcutaneous abscesses developing during miliary tuberculosis therapy","volume":"32","author":"Mert","year":"2000"}],"container-title":["The American Journal of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/111\/3\/article-p526.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/111\/3\/article-p526.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/111\/3\/article-p526.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,4]],"date-time":"2024-09-04T19:56:14Z","timestamp":1725479774000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/111\/3\/article-p526.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,4]]},"references-count":11,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.23-0514","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"type":"print","value":"0002-9637"},{"type":"electronic","value":"1476-1645"}],"subject":[],"published":{"date-parts":[[2024,9,4]]}}}