{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T00:43:31Z","timestamp":1779324211080,"version":"3.51.4"},"reference-count":32,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,4,3]]},"abstract":"<jats:title>ABSTRACT.<\/jats:title>\n<jats:p>Since the Zika virus (ZIKV) pandemic in 2015\u20132017, there has been a near absence of reported cases in the Americas outside of Brazil. However, the conditions for <jats:italic>Aedes<\/jats:italic>-borne transmission persist in Latin America, and the threat of ZIKV transmission is increasing as population immunity wanes. Mexico has reported only 70 cases of laboratory-confirmed ZIKV infection since 2020, with no cases recorded in the Yucat\u00e1n peninsula. Here, we provide evidence of active ZIKV transmission, despite the absence of official case reports, in the city of M\u00e9rida, Mexico, the capital of the state of Yucat\u00e1n. Capitalizing on an existing cohort, we detected cases in participants with symptoms consistent with flavivirus infection from 2021 to 2022. Serum samples from suspected cases were tested for ZIKV RNA by polymerase chain reaction or ZIKV-reactive IgM by ELISA. To provide more specific evidence of exposure, focus reduction neutralization tests were performed on ELISA-positive samples. Overall, we observed 25 suspected ZIKV infections for an estimated incidence of 2.8 symptomatic cases per 1,000 persons per year. Our findings emphasize the continuing threat of ZIKV transmission in the setting of decreased surveillance and reporting.<\/jats:p>","DOI":"10.4269\/ajtmh.23-0533","type":"journal-article","created":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T22:04:29Z","timestamp":1708466669000},"page":"724-730","source":"Crossref","is-referenced-by-count":7,"title":["Evidence of Ongoing Transmission of Zika Virus in M\u00e9rida, Mexico"],"prefix":"10.4269","volume":"110","author":[{"given":"James T.","family":"Earnest","sequence":"first","affiliation":[{"name":"Department of Environmental Sciences, Emory University, Atlanta, Georgia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karina Jacqueline","family":"Ciau-Carillo","sequence":"additional","affiliation":[{"name":"Laboratorio de Virologia, Centro de Investigaciones Regionales Dr. Hideyo Noguchi, Universidad Aut\u00f3noma de Yucat\u00e1n, M\u00e9rida, Mexico;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oscar D.","family":"Kirstein","sequence":"additional","affiliation":[{"name":"Department of Environmental Sciences, Emory University, Atlanta, Georgia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Azael","family":"Che-Mendoza","sequence":"additional","affiliation":[{"name":"Unidad Colaborativa para Bioensayos Entomologicos, Campus de Ciencias Biol\u00f3gicas y Agropecurias, Universidad Aut\u00f3noma de Yucat\u00e1n, M\u00e9rida, Mexico;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel O.","family":"Espinoza","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henry","family":"Puerta-Guardo","sequence":"additional","affiliation":[{"name":"Laboratorio de Virologia, Centro de Investigaciones Regionales Dr. Hideyo Noguchi, Universidad Aut\u00f3noma de Yucat\u00e1n, M\u00e9rida, Mexico;"},{"name":"Unidad Colaborativa para Bioensayos Entomologicos, Campus de Ciencias Biol\u00f3gicas y Agropecurias, Universidad Aut\u00f3noma de Yucat\u00e1n, M\u00e9rida, Mexico;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin","family":"Yam-Trujillo","sequence":"additional","affiliation":[{"name":"Laboratorio de Virologia, Centro de Investigaciones Regionales Dr. Hideyo Noguchi, Universidad Aut\u00f3noma de Yucat\u00e1n, M\u00e9rida, Mexico;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel","family":"Parra-Carde\u00f1a","sequence":"additional","affiliation":[{"name":"Laboratorio de Virologia, Centro de Investigaciones Regionales Dr. Hideyo Noguchi, Universidad Aut\u00f3noma de Yucat\u00e1n, M\u00e9rida, Mexico;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gloria A.","family":"Barrera-Fuentes","sequence":"additional","affiliation":[{"name":"Unidad Colaborativa para Bioensayos Entomologicos, Campus de Ciencias Biol\u00f3gicas y Agropecurias, Universidad Aut\u00f3noma de Yucat\u00e1n, M\u00e9rida, Mexico;"},{"name":"Laboratorio de Hematologia, Centro de Investigaciones Regionales Dr. Hideyo Noguchi, Universidad Aut\u00f3noma de Yucat\u00e1n, M\u00e9rida, Mexico;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norma","family":"Pavia-Ruz","sequence":"additional","affiliation":[{"name":"Laboratorio de Hematologia, Centro de Investigaciones Regionales Dr. Hideyo Noguchi, Universidad Aut\u00f3noma de Yucat\u00e1n, M\u00e9rida, Mexico;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabian","family":"Correa-Morales","sequence":"additional","affiliation":[{"name":"Centro Nacional de Programas Preventivos y Control de Enfermedades (CENAPRECE), Secretaria de Salud Mexico, Mexico City, Mexico;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hector","family":"Gomez-Dantes","sequence":"additional","affiliation":[{"name":"Health Systems Research Centre, National Institute of Public Health, Cuernavaca, Mexico;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pilar","family":"Granja-Perez","sequence":"additional","affiliation":[{"name":"Servicios de Salud de Yucat\u00e1n, M\u00e9rida, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salha","family":"Villanueva","sequence":"additional","affiliation":[{"name":"Servicios de Salud de Yucat\u00e1n, M\u00e9rida, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pablo","family":"Manrique-Saide","sequence":"additional","affiliation":[{"name":"Unidad Colaborativa para Bioensayos Entomologicos, Campus de Ciencias Biol\u00f3gicas y Agropecurias, Universidad Aut\u00f3noma de Yucat\u00e1n, M\u00e9rida, Mexico;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guadalupe","family":"Ayora-Talavera","sequence":"additional","affiliation":[{"name":"Laboratorio de Virologia, Centro de Investigaciones Regionales Dr. Hideyo Noguchi, Universidad Aut\u00f3noma de Yucat\u00e1n, M\u00e9rida, Mexico;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew H.","family":"Collins","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gonzalo","family":"Vazquez-Prokopec","sequence":"additional","affiliation":[{"name":"Department of Environmental Sciences, Emory University, Atlanta, Georgia;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2795","reference":[{"key":"b1","series-title":"Lancet","first-page":"861","article-title":"Infection-related microcephaly after the 2015 and 2016 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