{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T05:18:06Z","timestamp":1772255886048,"version":"3.50.1"},"reference-count":22,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,5,1]]},"abstract":"<jats:title>ABSTRACT.<\/jats:title>\n                  <jats:p>\n                    Chad has seen a considerable reduction in cases of Guinea worm disease (or dracunculiasis) in domestic dogs in recent years. Tethering of dogs and application of Abate\n                    <jats:sup>\u00ae<\/jats:sup>\n                    larvicide to water sources appear to have contributed to this progress, but with 767 reported dog cases in 2021, accelerating elimination of the disease in Chad may require additional tools. We investigate the potential benefits of a hypothetical diagnostic test that could be capable of detecting prepatent infections in dogs. We adapt an agent-based simulation model for forecasting the impact of interventions on guinea worm disease in dogs to examine the interaction of multiple test factors including test accuracy, when the test can detect infection, dog selection, and dog-owner compliance with tethering recommendations. We find that a diagnostic test could be successful if used in conjunction with existing interventions, and elimination can be achieved within 2\u2009years with 80% or higher test sensitivity, 90% or higher specificity, systematic testing of each dog twice per year, and more than 90% long-term tethering compliance when a dog tests positive or a worm is emerging. Because of the long incubation period of Guinea worm disease (10\u201314 months) and the fact that no treatment exists, the benefits of the test rely on the testing rollout and response of dog owners. If the test could estimate the timing of worm emergence, long-term tethering could be eliminated and infected dogs could be tethered only when the worms are expected, minimizing the related resources (human and financial) to support the intervention.\n                  <\/jats:p>","DOI":"10.4269\/ajtmh.23-0534","type":"journal-article","created":{"date-parts":[[2024,4,2]],"date-time":"2024-04-02T11:18:59Z","timestamp":1712056739000},"page":"953-960","source":"Crossref","is-referenced-by-count":1,"title":["Potential Impact of a Diagnostic Test for Detecting Prepatent Guinea Worm Infections in Dogs"],"prefix":"10.4269","volume":"110","author":[{"given":"Hannah","family":"Smalley","sequence":"first","affiliation":[{"name":"H. Milton Stewart School of Industrial and Systems Engineering, Georgia Institute of Technology, Atlanta, Georgia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pinar","family":"Keskinocak","sequence":"additional","affiliation":[{"name":"H. Milton Stewart School of Industrial and Systems Engineering, Georgia Institute of Technology, Atlanta, Georgia;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie","family":"Swann","sequence":"additional","affiliation":[{"name":"H. Milton Stewart School of Industrial and Systems Engineering, Georgia Institute of Technology, Atlanta, Georgia;"},{"name":"Edward P. Fitts Department of Industrial and Systems Engineering, North Carolina State University, Raleigh, North Carolina;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher","family":"Hanna","sequence":"additional","affiliation":[{"name":"Global Project Partners, LLC, Elmhurst, Illinois;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam","family":"Weiss","sequence":"additional","affiliation":[{"name":"Guinea Worm Eradication Program, The Carter Center, Atlanta, Georgia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2795","reference":[{"key":"b1","series-title":"MMWR Morb Mortal Wkly Rep","first-page":"1496","article-title":"Progress toward global eradication of dracunculiasis\u2014worldwide, January 2021\u2013June 2022","volume":"71","author":"Hopkins","year":"2022"},{"key":"b2","year":"2022"},{"key":"b3","series-title":"Am J Trop Med Hyg","first-page":"61","article-title":"The peculiar epidemiology of dracunculiasis in Chad","volume":"90","author":"Eberhard","year":"2014"},{"key":"b4","series-title":"Am J Trop Med Hyg","first-page":"373","article-title":"Dracunculiasis eradication: end-stage challenges","volume":"107","author":"Hopkins","year":"2022"},{"key":"b5","series-title":"Int J Infect Dis","first-page":"382","article-title":"Managing the risks of making the wrong diagnosis: first, do no harm","volume":"106","author":"Olliaro","year":"2021"},{"key":"b6","series-title":"PLoS Negl Trop Dis","first-page":"e0009740","article-title":"Assessment of the required performance and the development of corresponding program decision rules for neglected tropical diseases diagnostic tests: monitoring and evaluation of soil-transmitted helminthiasis control programs as a case study","volume":"15","author":"Levecke","year":"2021"},{"key":"b7","series-title":"PLoS Negl Trop Dis","first-page":"e0006529","article-title":"Minimum requirements and optimal testing strategies of a diagnostic test for leprosy as a tool towards zero transmission: a modeling study","volume":"12","author":"Blok","year":"2018"},{"key":"b8","series-title":"Mol Diagn Ther","first-page":"241","article-title":"A discrete event simulation model to assess the economic value of a hypothetical pharmacogenomics test for statin-induced myopathy in patients initiating a statin in secondary cardiovascular prevention","volume":"22","author":"Mitchell","year":"2018"},{"key":"b9","series-title":"Nature","first-page":"9","article-title":"Reducing the global burden of acute lower respiratory infections in children: the contribution of new diagnostics","volume":"444","author":"Lim","year":"2006"},{"key":"b10","series-title":"Lancet Infect Dis","first-page":"1109","article-title":"Overlooking the importance of immunoassays","volume":"16","author":"Dhillon","year":"2016"},{"key":"b11","series-title":"Sci Rep","first-page":"23009","article-title":"A SARS-CoV-2 antigen rapid diagnostic test for resource limited settings","volume":"11","author":"Frew","year":"2021"},{"key":"b12","series-title":"N Engl J Med","first-page":"e120","article-title":"Rethinking COVID-19 test sensitivity\u2014a strategy for containment","volume":"383","author":"Mina","year":"2020"},{"key":"b13","year":"2022"},{"key":"b14","series-title":"Am J Trop Med Hyg","first-page":"835","article-title":"Evaluating the effectiveness of potential intervention methods for Guinea worm disease in dogs in Chad using simulations","volume":"109","author":"Wang","year":"2023"},{"key":"b15","series-title":"Am J Trop Med Hyg","first-page":"1942","article-title":"Agent-based simulation for seasonal Guinea worm disease in Chad dogs","volume":"103","author":"Perini","year":"2020"},{"key":"b16","series-title":"Guinea Worm Wrap-up #266","year":"2020"},{"key":"b17","series-title":"Vaccine","first-page":"6876","article-title":"Resource allocation for different types of vaccines against COVID-19: tradeoffs and synergies between efficacy and reach","volume":"39","author":"Kim","year":"2021"},{"key":"b18","series-title":"PLoS Negl Trop Dis","first-page":"e0008170","article-title":"Ecology of domestic dogs Canis familiaris as an emerging reservoir of Guinea worm Dracunculus medinensis infection","volume":"14","author":"McDonald","year":"2020"},{"key":"b19","year":"2022"},{"key":"b20","series-title":"Guinea Worm Wrap-up #297","year":"2023"},{"key":"b21","series-title":"StatPearls","author":"Rawla","year":"2023"},{"key":"b22","year":"2023"}],"container-title":["The American Journal of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/110\/5\/article-p953.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/110\/5\/article-p953.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/110\/5\/article-p953.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T11:21:54Z","timestamp":1714562514000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/110\/5\/article-p953.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,1]]},"references-count":22,"journal-issue":{"issue":"5"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.23-0534","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2023.10.30.23297718","asserted-by":"object"}]},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"value":"0002-9637","type":"print"},{"value":"1476-1645","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,1]]}}}