{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T18:00:39Z","timestamp":1791655239725,"version":"4.3.4"},"reference-count":127,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,5,1]]},"abstract":"<jats:title>ABSTRACT.<\/jats:title>\n<jats:p>Dengue fever (DF) is an endemic infectious tropical disease and is rapidly becoming a global problem. Dengue fever is caused by one of the four dengue virus (DENV) serotypes and is spread by the female <jats:italic>Aedes<\/jats:italic> mosquito. Clinical manifestations of DF may range from asymptomatic to life-threatening severe illness with conditions of hemorrhagic fever and shock. Early and precise diagnosis is vital to avoid mortality from DF. A different approach is required to combat DF because of the challenges with the vaccines currently available, which are nonspecific; each is capable of causing cross-reaction and disease-enhancing antibody responses against the residual serotypes. MicroRNAs (miRNAs) are known to be implicated in DENV infection and are postulated to be involved in most of the host responses. Thus, they might be a suitable target for new strategies against the disease. The involvement of miRNAs in cellular activities and pathways during viral infections has been explored under numerous conditions. Interestingly, miRNAs have also been shown to be involved in viral replication. In this review, we summarize the role of known miRNAs, specifically the role of miRNA Let-7c (miR-Let-7c), miR-133a, miR-30e, and miR-146a, in the regulation of DENV replication and their possible effects on the initial immune reaction.<\/jats:p>","DOI":"10.4269\/ajtmh.23-0546","type":"journal-article","created":{"date-parts":[[2024,4,2]],"date-time":"2024-04-02T15:19:27Z","timestamp":1712071167000},"page":"856-867","source":"Crossref","is-referenced-by-count":2,"title":["Cross Talk between MicroRNAs and Dengue Virus"],"prefix":"10.4269","volume":"110","author":[{"given":"Nur Omar","family":"Macha","sequence":"first","affiliation":[{"name":"Infection and Immunity Research Strength, Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Selangor, Malaysia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thamil Vaani","family":"Komarasamy","sequence":"additional","affiliation":[{"name":"Infection and Immunity Research Strength, Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Selangor, Malaysia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarahani","family":"Harun","sequence":"additional","affiliation":[{"name":"Institute of Systems Biology Malaysia, National University of Malaysia, Selangor, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nur Amelia Azreen","family":"Adnan","sequence":"additional","affiliation":[{"name":"Infection and Immunity Research Strength, Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Selangor, Malaysia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharifah Syed","family":"Hassan","sequence":"additional","affiliation":[{"name":"Infection and Immunity Research Strength, Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Selangor, Malaysia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinod R. M. T.","family":"Balasubramaniam","sequence":"additional","affiliation":[{"name":"Infection and Immunity Research Strength, Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Selangor, Malaysia;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"2795","reference":[{"key":"b1","series-title":"PLoS Negl Trop Dis","first-page":"e2055","article-title":"Economic and disease burden of dengue in Southeast Asia","volume":"7","author":"Shepard","year":"2013"},{"key":"b2","series-title":"Nature","first-page":"504","article-title":"The global distribution and burden of dengue","volume":"496","author":"Bhatt","year":"2013"},{"key":"b3","series-title":"Front Microbiol","first-page":"743147","article-title":"Host molecules regulating neural invasion of Zika virus and drug repurposing strategy","volume":"13","author":"Tan","year":"2022"},{"key":"b4","series-title":"PLoS Negl Trop Dis","first-page":"e0010291","article-title":"Finding a chink in the armor: 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