{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T20:58:34Z","timestamp":1757451514349,"version":"3.38.0"},"reference-count":30,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,3,5]]},"abstract":"<jats:title>ABSTRACT.<\/jats:title>\n<jats:p>Mycetoma is a granulomatous disease of subcutaneous tissue that is caused by different species of aerobic filamentous bacteria (actinomycetoma) or fungi (eumycetoma). Mycetoma treatment depends on the causative pathogen, and it mainly consists of antimicrobial interventions or surgery. <jats:italic>Aspergillus terreus<\/jats:italic> is an etiologic agent of invasive aspergillosis and a rare cause of eumycetoma that is common in central and southern China. The present case report describes a 45-year-old female patient with subcutaneous swelling and multiple active and healed sinuses over the dorsal aspect of the left foot who was diagnosed with eumycetoma caused by <jats:italic>A. terreus<\/jats:italic>. This is the first such case reported in China. We applied a combination treatment consisting of itraconazole with topical luliconazole cream and radiofrequency microneedling, and this was followed by significant regression of the lesion. In addition, we reviewed the current literature to summarize the epidemiological characteristics of mycetoma in mainland China and cases of eumycetoma caused by <jats:italic>A. terreus<\/jats:italic> worldwide.<\/jats:p>","DOI":"10.4269\/ajtmh.23-0573","type":"journal-article","created":{"date-parts":[[2024,12,10]],"date-time":"2024-12-10T18:35:31Z","timestamp":1733855731000},"page":"548-552","source":"Crossref","is-referenced-by-count":1,"title":["Eumycetoma Caused by Aspergillus terreus: A Case Report and Literature Review"],"prefix":"10.4269","volume":"112","author":[{"given":"Xin","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Microbiology, Graduate School of Medicine, Kyoto University, Kyoto, Japan;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingrui","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Dermatology, The Second Hospital of Jilin University, Changchun, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sha","family":"Lv","sequence":"additional","affiliation":[{"name":"Department of Dermatology, The Second Hospital of Jilin University, Changchun, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhe","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Dermatology, The Second Hospital of Jilin University, Changchun, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ichiro","family":"Nakagawa","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Graduate School of Medicine, Kyoto University, Kyoto, Japan;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fuqiu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Dermatology, The Second Hospital of Jilin University, Changchun, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2795","reference":[{"key":"b1","series-title":"PLoS Negl Trop Dis","first-page":"e0011736","article-title":"Mycetoma and the environment","volume":"17","author":"Fahal","year":"2023"},{"key":"b2","series-title":"PLoS One","first-page":"e0231871","article-title":"Mycetoma epidemiology, diagnosis management, and outcome in three hospital centres in Senegal from 2008 to 2018","volume":"15","author":"Sow","year":"2020"},{"key":"b3","series-title":"Clin Exp Dermatol","first-page":"123","article-title":"Mycetoma: Reviewing a neglected disease","volume":"44","author":"Verma","year":"2019"},{"key":"b4","series-title":"Trans R Soc Trop Med Hyg","first-page":"12","article-title":"Mycetoma management and clinical outcomes: The Mycetoma Research Center experience","volume":"117","author":"Musa","year":"2023"},{"key":"b5","series-title":"Clin Microbiol Rev","first-page":"e0031120","article-title":"Aspergillus terreus species complex","volume":"34","author":"Lass-Fl\u00f6rl","year":"2021"},{"key":"b6","series-title":"Int J Antimicrob Agents","first-page":"281","article-title":"Treatment of Aspergillus terreus infections: A clinical problem not yet resolved","volume":"44","author":"Pastor","year":"2014"},{"key":"b7","series-title":"Ann Otol Rhinol Laryngol","first-page":"273","article-title":"Administration of 1% topical voriconazole drops was effective and safe in the treatment of refractory otomycosis without tympanic membrane perforation","volume":"130","author":"Zhang","year":"2021"},{"key":"b8","series-title":"J Eur Acad Dermatol Venereol","first-page":"1628","article-title":"Nondermatophyte mould onychomycosis","volume":"35","author":"Gupta","year":"2021"},{"key":"b9","series-title":"J Cosmet Dermatol","first-page":"S1","article-title":"Introduction and overview of radiofrequency treatments in aesthetic dermatology","volume":"21 (Suppl 1)","author":"Delgado","year":"2022"},{"key":"b10","series-title":"JAMA Dermatol","first-page":"1193","article-title":"Evidence-based clinical practice guidelines for laser-assisted drug delivery","volume":"158","author":"Labadie","year":"2022"},{"key":"b11","series-title":"PLoS Negl Trop Dis","first-page":"e0007056","article-title":"The accuracy of histopathological and cytopathological techniques in the identification of the mycetoma causative agents","volume":"13","author":"Siddig","year":"2019"},{"key":"b12","series-title":"Am J Clin Pathol","first-page":"493","article-title":"Antibiotic susceptibility testing by a standardized single disk method","volume":"45","author":"Bauer","year":"1966"},{"year":"2010","key":"b13","article-title":"Reference Method for Antifungal Disk Diffusion Susceptibility Testing of Non-Dermatophyte Filamentous Fungi; Approved Guideline. CLSI Document M51-A"},{"key":"b14","series-title":"Pediatr Dermatol","first-page":"e312","article-title":"Administration of oral itraconazole capsule with whole milk shows enhanced efficacy as supported by scanning electron microscopy in a child with tinea capitis due to Microsporum canis","volume":"32","author":"Chen","year":"2015"},{"key":"b15","series-title":"Drugs","first-page":"2405","article-title":"Triazole antifungal agents in invasive fungal infections: A comparative review","volume":"71","author":"Lass-Fl\u00f6rl","year":"2011"},{"key":"b16","series-title":"Mycoses","first-page":"650","article-title":"Eumycetoma causative agents are inhibited in\u00a0vitro by luliconazole, lanoconazole and ravuconazole","volume":"65","author":"Nyuykonge","year":"2022"},{"key":"b17","series-title":"Photobiomodul Photomed Laser Surg","first-page":"37","article-title":"Treatment of superficial mycoses using photodynamic therapy: A systematic review and meta-analysis","volume":"41","author":"Dong","year":"2023"},{"key":"b18","series-title":"Mycopathologia","first-page":"327","article-title":"Mycetoma in China: A case report and review of the literature","volume":"184","author":"Wang","year":"2019"},{"key":"b19","series-title":"J Eur Acad Dermatol Venereol","first-page":"1873","article-title":"Eumycetoma and actinomycetoma\u2014An update on causative agents, epidemiology, pathogenesis, diagnostics and therapy","volume":"29","author":"Nenoff","year":"2015"},{"key":"b20","series-title":"Clin Microbiol Rev","first-page":"e0003423","article-title":"An updated list of eumycetoma causative agents and their differences in grain formation and treatment response","volume":"37","author":"van de Sande","year":"2024"},{"key":"b21","series-title":"Indian J Dermatol","first-page":"529","article-title":"Mycetoma in Iran: Causative agents and geographic distribution","volume":"59","author":"Bassiri-Jahromi","year":"2014"},{"key":"b22","series-title":"Epidemiol Infect","first-page":"e294","article-title":"Epidemiological profile and spectrum of neglected tropical disease eumycetoma from Delhi, North India","volume":"147","author":"Dubey","year":"2019"},{"key":"b23","series-title":"Res Rep Trop Med","first-page":"173","article-title":"Clinical features of mycetoma and the appropriate treatment options","volume":"12","author":"Agarwal","year":"2021"},{"key":"b24","series-title":"Front Microbiol","first-page":"680884","article-title":"A 20-year antifungal susceptibility surveillance (from 1999 to 2019) for Aspergillus spp. and proposed epidemiological cutoff values for Aspergillus fumigatus and Aspergillus flavus: A study in a tertiary hospital in China","volume":"12","author":"Yang","year":"2021"},{"key":"b25","series-title":"J Mycol Med","first-page":"351","article-title":"Luliconazole, an alternative antifungal agent against 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