{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,4]],"date-time":"2024-07-04T00:15:28Z","timestamp":1720052128501},"reference-count":10,"publisher":"American Society of Tropical Medicine and Hygiene","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,7,3]]},"abstract":"<jats:title>ABSTRACT.<\/jats:title>\n<jats:p>Infections caused by free-living amoebae pose a significant public health threat owing to growing populations of immunocompromised hosts combined with diagnostic delays, treatment difficulties, and high case fatality rates. Nasopharyngeal infections caused by <jats:italic>Acanthamoeba<\/jats:italic> are rare and the optimal treatment is not well established. We report a case of <jats:italic>Acanthamoeba<\/jats:italic> rhinosinusitis in a patient with chronic lymphocytic leukemia who presented with headaches and chronic rhinosinusitis refractory to multiple courses of antibiotics. A diagnosis of <jats:italic>Acanthamoeba<\/jats:italic> rhinosinusitis was established through broad-range polymerase chain reaction testing on sinus tissue. The patient had a favorable response to treatment, which included surgical debridement, cessation of immunosuppressants, and a three-drug regimen consisting of miltefosine, fluconazole, and sulfadiazine.<\/jats:p>","DOI":"10.4269\/ajtmh.23-0582","type":"journal-article","created":{"date-parts":[[2024,6,4]],"date-time":"2024-06-04T15:25:20Z","timestamp":1717514720000},"page":"48-50","source":"Crossref","is-referenced-by-count":0,"title":["Case Report: Management of Acanthamoeba Rhinosinusitis in a Patient with Chronic Lymphocytic Leukemia"],"prefix":"10.4269","volume":"111","author":[{"given":"Elizabeth","family":"Di Valerio","sequence":"first","affiliation":[{"name":"University of Florida College of Medicine, Gainesville, Florida;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeb M.","family":"Justice","sequence":"additional","affiliation":[{"name":"Division of Rhinology and Skull Base Surgery, Department of Otolaryngology, University of Florida College of Medicine, Gainesville, Florida;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexis C.","family":"Gushiken","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Global Medicine, Department of Medicine, University of Florida College of Medicine, Gainesville, Florida;"},{"name":"Section of Infectious Diseases, North Florida\/South Georgia Veterans Health System, Gainesville, Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"2795","reference":[{"key":"b1","series-title":"Pathol Biol (Paris)","first-page":"399","article-title":"Pathogenic free-living amoebae: Epidemiology and clinical review","volume":"60","author":"Trabelsi","year":"2012"},{"key":"b2","series-title":"Open Forum Infect Dis","first-page":"ofac682","article-title":"The epidemiology and clinical features of non-keratitis Acanthamoeba infections in the United States, 1956\u20132020","volume":"10","author":"Haston","year":"2023"},{"key":"b3","series-title":"Otolaryngol Clin North Am","first-page":"1199","article-title":"Diseases of the nose and pnasal sinuses in the human immunodeficiency virus-infected population","volume":"25","author":"Tami","year":"1992"},{"key":"b4","series-title":"Ear Nose Throat J","first-page":"NP316","article-title":"An unusual source of sinonasal disease in an immunocompromised patient: A case report of the clinical presentation, diagnosis, and treatment of Acanthamoeba rhinosinusitis","volume":"101","author":"Guirguis","year":"2022"},{"key":"b5","series-title":"PLoS Negl Trop Dis","first-page":"e0008353","article-title":"Discovery of repurposing drug candidates for the treatment of diseases caused by pathogenic free-living amoebae","volume":"14","author":"Rice","year":"2020"},{"key":"b6","series-title":"Am J Surg Pathol","first-page":"102","article-title":"Sinonasal amoebiasis: An unexpected cause of sinonasal necroinflammatory disease","volume":"47","author":"McLean","year":"2023"},{"key":"b7","series-title":"Am J Rhinol","article-title":"Acanthamoeba rhinosinusitis: Characterization, diagnosis, and treatment","volume":"21","author":"Teknos","year":"2000"},{"key":"b8","series-title":"Clin Infect Dis","first-page":"778","article-title":"Understanding the promises and hurdles of metagenomic next-generation sequencing as a diagnostic tool for infectious diseases","volume":"66","author":"Simner","year":"2018"},{"key":"b9","series-title":"Clin Transl Sci","first-page":"791","article-title":"Drugs used for the treatment of cerebral and disseminated infections caused by free-living amoebae","volume":"14","author":"Taravaud","year":"2021"},{"key":"b10","year":"2017"}],"container-title":["The American Journal of Tropical Medicine and Hygiene"],"original-title":[],"link":[{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/111\/1\/article-p48.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/111\/1\/article-p48.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/www.ajtmh.org\/downloadpdf\/journals\/tpmd\/111\/1\/article-p48.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,3]],"date-time":"2024-07-03T13:34:06Z","timestamp":1720013646000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ajtmh.org\/view\/journals\/tpmd\/111\/1\/article-p48.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,3]]},"references-count":10,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.4269\/ajtmh.23-0582","relation":{},"ISSN":["0002-9637","1476-1645"],"issn-type":[{"value":"0002-9637","type":"print"},{"value":"1476-1645","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,3]]}}}